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    MAGNETOCHEMICAL SENSOR
    3.
    发明申请
    MAGNETOCHEMICAL SENSOR 审中-公开
    磁化学传感器

    公开(公告)号：US20110095756A1

    公开(公告)日：2011-04-28

    申请号：US12158065

    申请日：2006-11-24

    申请人： Michel Paul Barbara Van Bruggen ,  Mischa Megens ,  Hans Van Zon ,  Ralph Kurt ,  Roel Penterman ,  Emiel Peeters

    发明人： Michel Paul Barbara Van Bruggen ,  Mischa Megens ,  Hans Van Zon ,  Ralph Kurt ,  Roel Penterman ,  Emiel Peeters

    IPC分类号： G01R33/09

    CPC分类号： H01F1/0045 ,  B82Y25/00 ,  G01N35/0098 ,  H01F10/3268

    摘要： The application is directed to a sensor element for use in a magnetochemical sensor, which comprises a first gel-like material (10), especially a swellable hydrogel such as polyacrylamide, and a magnetic second material (20) in the form of particles, especially magnetite (Fe304) nanoparticles, embedded in the first material along with a receptor for an alalyte, eg glucose. Changes in magnetic field due to interaction with the analyte are detected with GMR element (50). Applications include biosensors, DNA testing devices, and high throughput screening.

    摘要翻译： 该应用涉及用于磁化学传感器的传感器元件，该传感器元件包括第一凝胶状材料（10），特别是诸如聚丙烯酰胺的可溶胀水凝胶和颗粒形式的磁性第二材料（20），特别是 磁铁矿（Fe304）纳米颗粒，与一种alalyte（例如葡萄糖）的受体一起嵌入第一种材料中。 用GMR元件（50）检测与分析物相互作用导致的磁场变化。 应用包括生物传感器，DNA测试设备和高通量筛选。

    HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE
    4.
    发明申请
    HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE 有权
    用于检测环境状态的基于HYDROGEL的设备

    公开(公告)号：US20100114072A1

    公开(公告)日：2010-05-06

    申请号：US12593305

    申请日：2008-04-02

    申请人： Ventzeslav Petrov Iordanov ,  Hendrika Cecilia Krijnsen ,  Michel Paul Barbara Van Bruggen ,  Anna-Maria Janner ,  Ralph Kurt

    发明人： Ventzeslav Petrov Iordanov ,  Hendrika Cecilia Krijnsen ,  Michel Paul Barbara Van Bruggen ,  Anna-Maria Janner ,  Ralph Kurt

    IPC分类号： A61M5/00 ,  G01F1/00 ,  G01N21/00

    CPC分类号： A61B5/1459 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/4839

    摘要： The invention relates to a transducer device (100,200,300,400) for detecting an environmental state or a change in the environmental state, in particular for detecting an environmental state within a biological material. The transducer device (100,200,300,400) comprises a channel (2,22,51) comprising a fluid, a hydrogel material (1,21,51), which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel (2,22,51) such that the volume of the channel (2,22,51) changes when the volume of the hydrogel material (1,21,51) changes. The transducer device (100,200,300,400) further comprises a sensor (11,12,25,35), which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel (2,22,51). By applying the transducer device (100,200,300,400) according to the invention within a bodily lumen, an accurate monitoring of physiological parameters, for which the hydrogel material (1,21,51) is sensitive, within the bodily lumen is possible. It is also possible to apply the transducer device (100,200,300,400) outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.

    摘要翻译： 本发明涉及用于检测环境状态或环境状态变化的换能器装置（100,200,300,400），特别是用于检测生物材料内的环境状态。 所述换能器装置（100,200,300,400）包括包含流体的通道（2,22,51），水凝胶材料（1,21,51），其适于在与环境材料接触时改变其体积，和/或 检测环境变化，并且其机械耦合到通道（2,22,51），使得当水凝胶材料（1,21,51）的体积变化时，通道（2,22,51）的体积改变 。 传感器装置（100,200,300,400）还包括传感器（11,12,25,35），其适于在检测到由通道的体积变化引起的流体的物理特性的变化时产生信号（ 2,22,51）。 通过将根据本发明的换能器装置（100,200,300,400）应用于体腔内，可以精确地监测身体内水凝胶材料（1,21,51）敏感的生理参数。 也可以将换能器装置（100,200,300,400）应用于体腔外，例如监测患者体外的血液。

    Hydrogel based device for detecting an environmental state
    5.
    发明授权
    Hydrogel based device for detecting an environmental state 有权
    用于检测环境状态的基于水凝胶的装置

    公开(公告)号：US08840839B2

    公开(公告)日：2014-09-23

    申请号：US12593305

    申请日：2008-04-02

    申请人： Ventzeslav Petrov Iordanov ,  Hendrika Cecilia Krijnsen ,  Michel Paul Barbara Van Bruggen ,  Anna-Maria Janner ,  Ralph Kurt

    发明人： Ventzeslav Petrov Iordanov ,  Hendrika Cecilia Krijnsen ,  Michel Paul Barbara Van Bruggen ,  Anna-Maria Janner ,  Ralph Kurt

    IPC分类号： G01N21/00 ,  A61B5/00 ,  A61B5/1459

    CPC分类号： A61B5/1459 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/4839

    摘要： A transducer device for detecting an environmental state within a biological material including a channel comprising a fluid, a hydrogel material, which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel such that the volume of the channel changes when the volume of the hydrogel material changes. The transducer device further includes a sensor, which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel. By applying the transducer device, an accurate monitoring of physiological parameters, for which the hydrogel material is sensitive is possible. It is also possible to apply the transducer device outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.

    摘要翻译： 一种用于检测生物材料内的环境状态的换能器装置，包括包含流体的通道，水凝胶材料，其在与环境材料接触时和/或当检测到环境变化时改变其体积，并且其是 机械地耦合到通道，使得当水凝胶材料的体积变化时，通道的体积变化。 换能器装置还包括传感器，其适于在检测到由通道的体积变化引起的流体的物理特性的变化时产生信号。 通过应用传感器装置，水凝胶材料敏感的生理参数的准确监测是可能的。 也可以将换能器装置应用于体腔外，例如监测患者体外的血液。

    DRUG DELIVERY SYSTEM WITH THERMOSWITCHABLE MEMBRANES
    7.
    发明申请
    DRUG DELIVERY SYSTEM WITH THERMOSWITCHABLE MEMBRANES 审中-公开
    具有热稳定膜的药物递送系统

    公开(公告)号：US20090317445A1

    公开(公告)日：2009-12-24

    申请号：US12375036

    申请日：2007-07-13

    申请人： Michel Paul Barbara Van Bruggen ,  Hendrika Cecilia Krijnsen ,  Ventzeslav Petrov Iordanov ,  Anna-Maria Janner

    发明人： Michel Paul Barbara Van Bruggen ,  Hendrika Cecilia Krijnsen ,  Ventzeslav Petrov Iordanov ,  Anna-Maria Janner

    IPC分类号： A61K9/00

    CPC分类号： A61M37/00 ,  A61M2037/0007

    摘要： The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion. The present invention also provides a method for modulating the release of molecules, using such a device.

    摘要翻译： 本发明提供了用于分子控制释放的装置。 该装置特别适用于向患者控制释放治疗药物。 该装置包括具有用于从壳体释放分子的开口的壳体。 壳体还包括用于容纳分子的储库，特别是治疗药物。 储存器布置在壳体中以允许分子通过开口释放。 该装置还包括至少一个可热转换膜和至少一个用于至少部分地加热膜的加热元件。 该装置被配置为使用加热元件通过加热膜来调节开口处分子的释放。 可选地，所述装置还包括用于从所述装置提供所述分子的加压释放的压力元件。 以这种方式，药物可以以脉动方式递送给患者。 本发明还提供了使用这种装置调节分子释放的方法。

    Light-Emitting Diode
    8.
    发明申请
    Light-Emitting Diode 审中-公开
    发光二极管

    公开(公告)号：US20080251809A1

    公开(公告)日：2008-10-16

    申请号：US11569702

    申请日：2005-05-25

    申请人： Ronald M. Wolf ,  Michel Paul Barbara Van Bruggen

    发明人： Ronald M. Wolf ,  Michel Paul Barbara Van Bruggen

    IPC分类号： H01L33/00

    CPC分类号： H01L33/16 ,  H01L33/32

    摘要： Light-emitting diode (LED) comprising a translucent substrate of α-Al2O3 or SiC and a first layer of a light-emitting semiconductor material grown on a first side of said substrate, a first electrode and a second electrode, wherein said substrate is polycrystalline. The average grain size of the polycrystalline substrate is preferably of the same order as the wavelength of the light emitted by the semiconductor material during use of the LED.

    摘要翻译： 包含α-Al 2 O 3或SiC的半透明基板的发光二极管（LED）和在第一侧生长的发光半导体材料的第一层 的第一电极和第二电极，其中所述衬底是多晶的。 多晶衬底的平均晶粒尺寸优选地与在使用LED期间由半导体材料发射的光的波长相同。

    Method for Manufacturing a Component Having a Three-Dimensional Structure in a Surface Region and a Ceramic Component
    10.
    发明申请
    Method for Manufacturing a Component Having a Three-Dimensional Structure in a Surface Region and a Ceramic Component 审中-公开
    在表面区域和陶瓷部件中制造具有三维结构的部件的方法

    公开(公告)号：US20080217796A1

    公开(公告)日：2008-09-11

    申请号：US12064634

    申请日：2006-08-14

    申请人： Michel Paul Barbara Van Bruggen ,  Marcus Antonius Verschuuren

    发明人： Michel Paul Barbara Van Bruggen ,  Marcus Antonius Verschuuren

    IPC分类号： B29D11/00

    CPC分类号： B81C1/00 ,  B81C1/0046 ,  B81C99/009

    摘要： A method of manufacturing a component having a three-dimensional structure in a surface region, includes:—a step of forming a substantially solid layer (13) of material, which step comprises the steps of applying a substantially fluid composition over a surface, and—a step of removing an intermediate composition (12), impervious to at least a component of the substantially fluid composition and occupying at least part of the three-dimensional structure when the substantially fluid composition has at least partially set. The step of forming the substantially solid layer (13) of material is preceded by the steps of—providing a structure including recessed parts (5 to 7) on a surface of a substantially solid further layer (3), and—applying the intermediate composition (12) so as at least partially to fill at least the recessed parts (5 to 7) of the structure on the surface of the substantially solid further layer (3).

    摘要翻译： 一种在表面区域制造具有三维结构的部件的方法包括： - 形成基本上固体的材料层（13）的步骤，该步骤包括以下步骤：在表面上施加基本上流体的组合物，以及 - 当基本上流体组合物至少部分地固化时，去除不能渗透至基本上流体组合物的至少一种组分并占据至少一部分三维结构的中间组合物（12）的步骤。 形成材料的基本上固体层（13）的步骤之前是提供在基本上固体的另外的层（3）的表面上包括凹部（5至7）的结构的步骤，并且施加中间组合物 （12），以至少部分地填充至少基本上固体的另外的层（3）的表面上的结构的凹部（5至7）。