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    Shape Changing Playing Pieces
    3.
    发明申请
    Shape Changing Playing Pieces 审中-公开
    形状改变播放件

    公开(公告)号：US20080224395A1

    公开(公告)日：2008-09-18

    申请号：US12091178

    申请日：2006-10-27

    申请人： Michel Marcel Jose Decre ,  Johannes Theodorus Adriaan Wilderbeek ,  Ralph Kurt ,  Jacob Marinus Jan Den Toonder

    发明人： Michel Marcel Jose Decre ,  Johannes Theodorus Adriaan Wilderbeek ,  Ralph Kurt ,  Jacob Marinus Jan Den Toonder

    IPC分类号： A63F9/00 ,  A63F3/00

    CPC分类号： A63F3/00643 ,  A63F3/00697 ,  A63F2003/00678 ,  A63F2003/00826

    摘要： A playing piece (10, 20) for use in a board game, and comprising at least one shapeable segment (11, 21), an input (12) and shaping means (13). An input signal from an outside control unit (17) is received at the input (12), the input signal representing a particular shape and/or size of the playing piece (10, 20). The shaping means (13) couples the input (12) to the shapeable segment (11, 21) to deform the shapeable segment (11, 21) in dependence of the input signal, for obtaining the particular shape and/or size of the playing piece (10, 20).

    摘要翻译： 一种用于棋盘游戏的游戏玩具（10,20），包括至少一个可塑段（11,21），输入（12）和整形装置（13）。 来自外部控制单元（17）的输入信号在输入端（12）被接收，该输入信号表示播放器（10,20）的特定形状和/或尺寸。 成形装置（13）将输入（12）耦合到可形成段（11,21），以根据输入信号使可塑段（11,21）变形，以获得播放的特定形状和/或尺寸 （10,20）。

    Device for franmenting molecules in a sample by ultrasound
    5.
    发明授权
    Device for franmenting molecules in a sample by ultrasound 有权
    用于通过超声波使样品中的分子残留的装置

    公开(公告)号：US09108220B2

    公开(公告)日：2015-08-18

    申请号：US14117378

    申请日：2012-06-05

    申请人： Cristian Bogdan Craus ,  Jacob Marinus Jan Den Toonder ,  Roel Penterman ,  Pieter Jan Van Der Zaag

    发明人： Cristian Bogdan Craus ,  Jacob Marinus Jan Den Toonder ,  Roel Penterman ,  Pieter Jan Van Der Zaag

    IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  B06B3/00 ,  B02C19/18 ,  C12M1/00 ,  G01N1/28

    CPC分类号： B06B3/00 ,  B02C19/18 ,  C12M47/06 ,  G01N1/286 ,  Y10T29/49826

    摘要： According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.

    摘要翻译： 根据本发明的一个方面，提供了一种通过超声将碎片分子分解的装置。 该装置包括具有容器状形状的平面形状的盒和碎片装置。 通过在破碎仪器中施加低压力，将药筒拉向碎裂仪器，因此空间上封闭由碎裂仪器组成的流体隔室。 之后，可以处理包含在药筒的样品室中的样品的超声处理。 密封层设置在药筒和碎裂仪器之间，以便牢固地保持药筒的固定，以便防止流体隔室泄漏。

    Device and method for transporting magnetic or magnetisable beads
    9.
    发明授权
    Device and method for transporting magnetic or magnetisable beads 有权
    用于运输磁性或可磁化珠粒的装置和方法

    公开(公告)号：US08932540B2

    公开(公告)日：2015-01-13

    申请号：US13395321

    申请日：2010-09-06

    申请人： Jacob Marinus Jan Den Toonder ,  Pieter Jan Van Der Zaag ,  Hao Chieh Chao

    发明人： Jacob Marinus Jan Den Toonder ,  Pieter Jan Van Der Zaag ,  Hao Chieh Chao

    IPC分类号： B01L99/00 ,  B03C1/034 ,  B01L3/00 ,  B03C1/033 ,  B03C1/24

    CPC分类号： B03C1/034 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/043 ,  B03C1/0335 ,  B03C1/24 ,  B03C2201/18

    摘要： A device for transporting magnetic or magnetizable beads over a transport surface includes a chamber holding magnetic or magnetizable beads in a fluid, a transport element including the transport surface within the chamber, and a current wire structure including at least two sets of meandering current wires arranged on a side of the transport element opposite to the transport surface. The at least two sets are displaced with respect to each other in at least two directions. A switching unit switches currents individually applied to the sets of current wires according to a current driving scheme resulting in a transport of the beads over the transport surface.

    摘要翻译： 用于在输送表面上传送磁性或可磁化珠的装置包括在流体中容纳磁性或可磁化珠粒的腔室，包括腔室内的输送表面的输送元件，以及包括至少两组曲折的电流布线的电流线结构， 在运输元件的与运输表面相对的一侧。 至少两组相对于彼此在至少两个方向上移位。 开关单元根据当前的驱动方案来切换单独施加到电流线组的电流，从而导致小珠在输送表面上的传送。

    DEVICES AND METHODS FOR MICROARRAY SELECTION
    10.
    发明申请
    DEVICES AND METHODS FOR MICROARRAY SELECTION 有权
    MICROARRAY选择的设备和方法

    公开(公告)号：US20120165219A1

    公开(公告)日：2012-06-28

    申请号：US13393255

    申请日：2010-08-26

    申请人： Pieter Jan Van Der Zaag ,  Harma Feitsma ,  Jacob Marinus Jan Den Toonder ,  Reinhold Wimberger-Friedl

    发明人： Pieter Jan Van Der Zaag ,  Harma Feitsma ,  Jacob Marinus Jan Den Toonder ,  Reinhold Wimberger-Friedl

    IPC分类号： C40B30/04 ,  C40B60/12

    CPC分类号： C12Q1/6834 ,  C12Q2537/149 ,  C12Q2527/107

    摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.

    摘要翻译： 本发明涉及用于特异性选择靶分子的装置，其包括：（a）包含微阵列的至少一个反应区，其中所述微阵列包含其上固定有一种或多种捕获分子的底物，其包含一个 或更多温度控制和/或调节单元，用于控制和/或调节该区域内的温度; （b）至少一个非反应区，包括一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）能够产生和/或调节所述反应区（a）和包括一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的至少一个输送装置。 本发明还涉及用于特异性选择靶分子的装置，其中固定的捕获分子以斑点，细长斑点和/或线的形式组织在微阵列中。 在另一方面，本发明涉及一种特异性选择靶分子的方法，包括向这种装置中引入培养基，在反应区中进行相互作用反应，将不相互作用或不结合的靶分子传输到允许重新激活 目标分子，并在反应区域与再活化的靶分子进行额外的相互作用反应，以及使用这种用于特异性选择靶分子的装置，例如 对于目标富集，文献中也称为基于微阵列的基因组选择（MGS）。