Structuring hydrogels
    1.
    发明授权
    Structuring hydrogels 有权
    结构水凝胶

    公开(公告)号:US08535879B2

    公开(公告)日:2013-09-17

    申请号:US11752341

    申请日:2007-05-23

    Abstract: The present invention relates to a method for the preparation of a surface structured bulk hydrogel bearing a topographic and chemical pattern, comprising the steps of: (i) providing a primary master having a predetermined topographic pattern, (ii) replicating said primary master by an elastomeric secondary master to obtain a secondary master with said predetermined topographic pattern in its inverse form, (iii) replicating said secondary master by an imprintable curable material of hydrogel precursor molecules which are capable of forming a hydrogel once crosslinked by curing, and crosslinking said material to thereby yield a replica made of cross-linked bulk hydrogel bearing the topographic pattern identical to that of the primary master, and (iv) functionalizing, particularly biofunctionalizing, the bulk hydrogel replica.

    Abstract translation: 本发明涉及一种用于制备具有地形和化学图案的表面结构体积水凝胶的方法,其包括以下步骤:(i)提供具有预定地形图案的主母板,(ii)通过 以获得具有相反形式的所述预定地形图案的次级母版,(iii)通过水凝胶前体分子的可压印可固化材料复制所述次级母版,所述可水解凝胶前体分子能够通过固化形成水凝胶一次交联,并交联所述材料 从而产生由交联体积水凝胶制成的复制品,其具有与初级母料相同的地形图案,和(iv)主体水凝胶复制品的功能化,特别是生物功能化。

    Biosensor system based on recognition induced birefringence (RIB)
    3.
    发明授权
    Biosensor system based on recognition induced birefringence (RIB) 有权
    基于识别诱导双折射(RIB)的生物传感器系统

    公开(公告)号:US08465968B2

    公开(公告)日:2013-06-18

    申请号:US12645005

    申请日:2009-12-22

    Abstract: The present invention relates to a label-free biosensor system, a method for manufacturing said label-free biosensor system, its use for detecting biochemical reactions and/or bindings, enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and protein-ligand interactions, as well as an assay method for detecting and/or quantifying an analyte of interest in a biological sample which comprises detecting the Recognition Induced Birefringence (RIB) generated in the presence as opposed to the absence of said analyte by bringing said sample into contact with said label-free biosensor system.

    Abstract translation: 本发明涉及无标记生物传感器系统,制造所述无标记生物传感器系统的方法,其用于检测生化反应和/或结合的用途,酶反应,核酸杂交,蛋白质 - 蛋白质相互作用和蛋白质 - 配体相互作用 以及用于检测和/或定量生物样品中感兴趣的分析物的测定方法,其包括检测在存在下产生的识别诱导双折射(RIB),而不是通过使所述样品与所述分析物接触而不存在所述分析物 表示无标签的生物传感器系统。

    Layout information for data component
    5.
    发明授权
    Layout information for data component 有权
    数据组件的布局信息

    公开(公告)号:US07836392B2

    公开(公告)日:2010-11-16

    申请号:US11063000

    申请日:2005-02-22

    Abstract: In a computer system that is configured to contain schema definitions for several data components, layout information for at least one of the data components is stored in the schema definition for the at least one data component. A method of providing display of data in a graphical user interface includes accessing layout information for a data component, the layout information being included in a schema definition for the data component, and providing, using the accessed layout information, an instance of the data component for display in a graphical user interface. A browser can parse XSD artifacts of reusable building blocks and generate a graphical user interface with the embedded relative layout information of every building block.

    Abstract translation: 在被配置为包含多个数据组件的模式定义的计算机系统中,用于至少一个数据组件的布局信息被存储在至少一个数据组件的模式定义中。 提供在图形用户界面中显示数据的方法包括访问数据组件的布局信息,所述布局信息被包括在所述数据组件的模式定义中,以及使用所访问的布局信息提供所述数据组件的实例 用于在图形用户界面中显示。 浏览器可以解析可复用构建块的XSD工件,并生成具有每个构建块的嵌入式相对布局信息的图形用户界面。

    SILYL-FUNCTIONAL LINEAR PREPOLYMERS, PRODUCTION AND USE THEREOF
    6.
    发明申请
    SILYL-FUNCTIONAL LINEAR PREPOLYMERS, PRODUCTION AND USE THEREOF 审中-公开
    丝素官能线性预聚物,生产和使用

    公开(公告)号:US20100209612A1

    公开(公告)日:2010-08-19

    申请号:US12708573

    申请日:2010-02-19

    Abstract: The invention relates to coatings with a contact angle hysteresis in water as measured by the tilting plate method of at most 20° made from silyl-terminated linear prepolymers which may cross-link with the surface of the substrate for coating, wherein the silyl-terminated linear prepolymers may be obtained by reaction of compounds of general formula (I): X-A-X′ (I), where A=a polyoxyalkylene chain of ethylene oxide units or ethylene oxide and propylene oxide units with a maximum fraction of 50 wt. % of propylene oxide units based on the weight of A, X═OH, NH2, NHR, NR2 or OR, wherein R independently=a linear or branched 1-10 C alkyl, a 6-10 C alkaryl or aralkyl or a 5-10 C aryl and the compound of general formula (I) has a number average molecular weight of at least 100 g/mol, with compounds of general formula (II) Y—B—Si(OR1)r(R2)3−r, where Y=a group reactive with OH, NH2, NHR and/or NR2, B=a chemical bond or a divalent low-molecular weight organic group with preferably 1-50 carbon atoms, OR1=a hydrolysable group, R2=a linear or branched 1-6C alkyl and r=a number from 1 to 3 and optionally unreacted hydrogen atoms on the group X and/or the group X′ are optionally alkylated. The invention further relates to the production of such coatings and the use of the silyl-terminated linear pre-polymers from production of such coatings and application in mixtures with stellate silylated prepolymers.

    Abstract translation: 本发明涉及通过倾斜板法测量的水中接触角滞后的涂层,其由甲硅烷基封端的线性预聚物制成,其可以与用于涂覆的基材的表面交联,其中甲硅烷基封端 线性预聚物可以通过使通式(I)的化合物:XAX'(I)反应得到,其中A =环氧乙烷单元的聚氧化烯链或环氧乙烷和环氧丙烷单元,最大分数为50wt。 基于A,X = OH,NH 2,NHR,NR 2或OR的重量的环氧丙烷单元的%,其中R独立地为直链或支链的1-10C烷基,6-10C烷芳基或芳烷基或5- 10的芳基和通式(I)的化合物的数均分子量至少为100g / mol,与通式(Ⅱ)Y-B-Si(OR1)r(R2)3-r的化合物, 其中Y =与OH,NH 2,NHR和/或NR 2反应的基团,B =具有优选1-50个碳原子的化学键或二价低分子量有机基团,OR 1 =可水解基团,R 2 =直链或 支化的1-6C烷基和r = 1至3的数和任选的X基团和/或X'基团上未反应的氢原子任选被烷基化。 本发明进一步涉及这种涂层的生产以及由这种涂层的生产使用甲硅烷基封端的线性预聚物以及与星状甲硅烷基化预聚物的混合物的应用。

    Multifunctional stellate prepolymer mixtures, production and use and coatings made thereof
    7.
    发明授权
    Multifunctional stellate prepolymer mixtures, production and use and coatings made thereof 有权
    多功能星状预聚物混合物,其制备和使用以及涂层

    公开(公告)号:US08816000B2

    公开(公告)日:2014-08-26

    申请号:US12709559

    申请日:2010-02-22

    Abstract: The invention relates to coatings having a contact angle hysteresis with water measured by the sessile drop method of at most 20°. The coatings can be produced from a mixture of at least two different stellate prepolymers and/or stellate prepolymer/nanoparticle complexes which may cross-link to each other and to the surface of the substrate coated, wherein the stellate prepolymers and/or stellate prepolymer/nanoparticle complex have at least three hydrophilic polymer branches before cross-linking which are themselves soluble in water with on all or a part of the free ends thereof, silyl end groups R1 of general formula (I): R1=—CRa2—Si(ORb)r(Rc)3−r, where Ra=H or straight or branched chain 1-6C alkyl, ORb=a hydrolysable group, Rc=linear or branched chain 1-6C alkyl and r=a number from 1 to 3 and the optionally non silyl end group carrying ends have reactive end groups which a reactive with each other, with the substrate to be coated optional entities included in the coating and/or with the silyl end groups with the proviso the mixture (a) has at least one stellate prepolymer with 3-5 hydrophilic polymer branches and (b) at least one stellate prepolymer and/or a stellate prepolymer/nanoparticle complex with a least 6 hydrophilic polymer branches. The invention further relates to a method for production for said coatings and stellate prepolymers as used in the coatings. The invention furthermore relates to the use of the stellate prepolymers as additives in various materials for temporary or permanent anti-soiling treatment of surfaces.

    Abstract translation: 本发明涉及具有至多20°的无固定滴落法测量的与水接触角滞后的涂层。 涂层可以由至少两种不同的星状预聚物和/或星状预聚物/纳米颗粒络合物的混合物制备,所述星状预聚物和/或星状预聚物/纳米颗粒复合物可以彼此交联并与涂覆的基材的表面交联,其中星状预聚物和/或星状预聚物/ 纳米颗粒络合物在交联之前具有至少三个亲水性聚合物分支,其自身可以在其全部或部分自由端上溶解在水中,通式(I)的甲硅烷基端基R1:R1 = -CRa2-Si(ORb )r(Rc)3-r,其中R a = H或直链或支链1-6C烷基,ORb =可水解基团,Rc =直链或支链1-6C烷基,r = 1至3的数, 任选的非甲硅烷基端基的端部具有彼此反应的反应性端基,待涂覆的底物包含在涂层中的任选实体和/或甲硅烷基端基,条件是混合物(a)具有至少一个 星状预聚物与3-5亲水聚合物麸 c)和(b)至少一种具有至少6个亲水性聚合物分支的星状预聚物和/或星状预聚物/纳米颗粒络合物。 本发明还涉及用于涂料中的所述涂料和星状预聚物的生产方法。 本发明还涉及星状预聚物作为各种材料中的添加剂用于表面的临时或永久性防污处理的用途。

    MULTIFUNCTIONAL STELLATE PREPOLYMER MIXTURES, PRODUCTION AND USE AND COATINGS MADE THEREOF
    8.
    发明申请
    MULTIFUNCTIONAL STELLATE PREPOLYMER MIXTURES, PRODUCTION AND USE AND COATINGS MADE THEREOF 有权
    多功能硅酸盐预处理剂的混合物,生产和使用及其涂料

    公开(公告)号:US20100209613A1

    公开(公告)日:2010-08-19

    申请号:US12709559

    申请日:2010-02-22

    Abstract: The invention relates to coatings having a contact angle hysteresis with water measured by the sessile drop method of at most 20°. The coatings can be produced from a mixture of at least two different stellate prepolymers and/or stellate prepolymer/nanoparticle complexes which may cross-link to each other and to the surface of the substrate coated, wherein the stellate prepolymers and/or stellate prepolymer/nanoparticle complex have at least three hydrophilic polymer branches before cross-linking which are themselves soluble in water with on all or a part of the free ends thereof, silyl end groups R1 of general formula (I): R1=—CRa2—Si(ORb)r(Rc)3-r, where Ra=H or straight or branched chain 1-6C alkyl, ORb=a hydrolysable group, Rc=linear or branched chain 1-6C alkyl and r=a number from 1 to 3 and the optionally non silyl end group carrying ends have reactive end groups which a reactive with each other, with the substrate to be coated optional entities included in the coating and/or with the silyl end groups with the proviso the mixture (a) has at least one stellate prepolymer with 3-5 hydrophilic polymer branches and (b) at least one stellate prepolymer and/or a stellate prepolymer/nanoparticle complex with a least 6 hydrophilic polymer branches. The invention further relates to a method for production for said coatings and stellate prepolymers as used in the coatings. The invention furthermore relates to the use of the stellate prepolymers as additives in various materials for temporary or permanent anti-soiling treatment of surfaces.

    Abstract translation: 本发明涉及具有至多20°的无固定滴落法测量的与水接触角滞后的涂层。 涂层可以由至少两种不同的星状预聚物和/或星状预聚物/纳米颗粒络合物的混合物制备,所述星状预聚物和/或星状预聚物/纳米颗粒复合物可以彼此交联并与涂覆的基材的表面交联,其中星状预聚物和/或星状预聚物/ 纳米颗粒络合物在交联之前具有至少三个亲水性聚合物分支,其自身可以在其全部或部分自由端上溶解在水中,通式(I)的甲硅烷基端基R1:R1 = -CRa2-Si(ORb )r(Rc)3-r,其中R a = H或直链或支链1-6C烷基,ORb =可水解基团,Rc =直链或支链1-6C烷基,r = 1至3的数, 任选的非甲硅烷基端基的端部具有彼此反应的反应性端基,待涂覆的底物包含在涂层中的任选实体和/或甲硅烷基端基,条件是混合物(a)具有至少一个 星状预聚物与3-5亲水聚合物分支 和(b)至少一种具有至少6个亲水性聚合物分支的星状预聚物和/或星状预聚物/纳米颗粒络合物。 本发明还涉及用于涂料中的所述涂料和星状预聚物的生产方法。 本发明还涉及星状预聚物作为各种材料中的添加剂用于表面的临时或永久性防污处理的用途。

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