-
公开(公告)号:US20110218198A1
公开(公告)日:2011-09-08
申请号:US13002168
申请日:2009-06-04
申请人: Margarita Wucherer-Plietker , David Bruce , Dirk Finsinger , Ulrich Graedler , Dieter Dorsch , Christina Esdar
发明人: Margarita Wucherer-Plietker , David Bruce , Dirk Finsinger , Ulrich Graedler , Dieter Dorsch , Christina Esdar
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/506 , A61P35/00 , A61P35/04
CPC分类号: C07D471/04
摘要: Compounds of the formula I in which X, R1, R2, R3, R4 and R6 have the meanings indicated in Claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
摘要翻译: 其中X,R 1,R 2,R 3,R 4和R 6具有权利要求1所述含义的式I化合物是细胞增殖/细胞活力的抑制剂,可用于治疗肿瘤。
-
公开(公告)号:US08420820B2
公开(公告)日:2013-04-16
申请号:US13002168
申请日:2009-06-04
申请人: Margarita Wucherer-Plietker , David Bruge , Dirk Finsinger , Ulrich Graedler , Dieter Dorsch , Christina Esdar
发明人: Margarita Wucherer-Plietker , David Bruge , Dirk Finsinger , Ulrich Graedler , Dieter Dorsch , Christina Esdar
IPC分类号: C07D471/02 , C07D413/00
CPC分类号: C07D471/04
摘要: Compounds of the formula I in which X, R1, R2, R3, R4 and R6 have the meanings indicated in Claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
摘要翻译: 其中X,R 1,R 2,R 3,R 4和R 6具有权利要求1所述含义的式I化合物是细胞增殖/细胞活力的抑制剂,可用于治疗肿瘤。
-
公开(公告)号:US20080318934A1
公开(公告)日:2008-12-25
申请号:US12158333
申请日:2006-11-28
申请人: Melanie Schultz , Lars Thore Burgdorf , Dirk Finsinger , Andree Blaukat , Hartmut Greiner , Christina Esdar
发明人: Melanie Schultz , Lars Thore Burgdorf , Dirk Finsinger , Andree Blaukat , Hartmut Greiner , Christina Esdar
IPC分类号: A61K31/551 , C07D487/14
CPC分类号: C07D487/04
摘要: The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases in the development or course of which kinases are involved.
摘要翻译: 本发明涉及式(I)化合物的制备和用途,其用于制备用于治疗疾病,特别是涉及激酶发展过程中的肿瘤和/或疾病的药物。
-
公开(公告)号:US07943608B2
公开(公告)日:2011-05-17
申请号:US12158333
申请日:2006-11-28
申请人: Melanie Schultz , Lars Thore Burgdorf , Dirk Finsinger , Andree Blaukat , Hartmut Greiner , Christina Esdar
发明人: Melanie Schultz , Lars Thore Burgdorf , Dirk Finsinger , Andree Blaukat , Hartmut Greiner , Christina Esdar
IPC分类号: C07D487/04 , A61K31/5517
CPC分类号: C07D487/04
摘要: The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases in the development or course of which kinases are involved.
摘要翻译: 本发明涉及式(I)化合物的制备和用途,其用于制备用于治疗疾病,特别是涉及激酶发展过程中的肿瘤和/或疾病的药物。
-
公开(公告)号:US07875614B2
公开(公告)日:2011-01-25
申请号:US11886294
申请日:2006-02-21
申请人: Hans-Peter Buchstaller , Dirk Finsinger , Kai Schiemann , Ulrich Emde , Frank Zenke , Christiane Amendt
发明人: Hans-Peter Buchstaller , Dirk Finsinger , Kai Schiemann , Ulrich Emde , Frank Zenke , Christiane Amendt
IPC分类号: C07D237/32 , A61K31/502 , A61P35/00 , A61P9/10 , A61P29/00 , A61P19/02 , A61P25/28
CPC分类号: C07D237/32
摘要: Compounds of the formula I, in which R, R1, R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3 and Y1 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours
摘要翻译: 其中R,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8,Z 1,Z 2,Z 3和Y 1具有权利要求1所述的含义的式I化合物可特别用于 治疗肿瘤
-
公开(公告)号:US07868172B2
公开(公告)日:2011-01-11
申请号:US10583689
申请日:2004-12-14
申请人: Kai Schiemann , Ulrich Emde , Dirk Finsinger , Johannes Gleitz , Helmut Reubold , Frank Zenke
发明人: Kai Schiemann , Ulrich Emde , Dirk Finsinger , Johannes Gleitz , Helmut Reubold , Frank Zenke
IPC分类号: C07D455/03 , A61K31/436
CPC分类号: C07D401/04 , A61K31/4706 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D401/14 , C07D409/14 , C07D491/04 , C07D491/052 , C07D491/14 , A61K2300/00
摘要: Compounds of the formula I, in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours
摘要翻译: 其中W,R,R 1,R 2,R 3,R 4,R 5,R 6和R 7具有权利要求1中所示含义的式I化合物,尤其可用于治疗肿瘤
-
公开(公告)号:US20090118267A1
公开(公告)日:2009-05-07
申请号:US11817757
申请日:2006-02-13
申请人: Dirk Finsinger , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Kai Schiemann , Wolfgang Staehle , Christiane Amendt , Nina Heiss , Frank Zenke
发明人: Dirk Finsinger , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Kai Schiemann , Wolfgang Staehle , Christiane Amendt , Nina Heiss , Frank Zenke
IPC分类号: A61K31/5375 , C07C211/28 , C07D211/70 , C07D221/16 , C07D265/30 , C07D241/04 , A61K31/4525 , A61K31/496 , A61K31/4545 , A61K31/4965 , C07D405/02 , C07D401/06 , A61K31/135 , A61K31/445
CPC分类号: C07D405/08 , C07C45/46 , C07C49/67 , C07C49/747 , C07C49/755 , C07C225/22 , C07C255/56 , C07D211/14 , C07D211/70 , C07D221/16 , C07D295/03
摘要: Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译: 其中R1,R2,R3,R4和q具有权利要求1所述含义的式(I)化合物可用于治疗肿瘤。
-
公开(公告)号:US08524732B2
公开(公告)日:2013-09-03
申请号:US12532002
申请日:2008-02-21
申请人: Kai Schiemann , Dirk Finsinger , Christiane Amendt , Frank Zenke
发明人: Kai Schiemann , Dirk Finsinger , Christiane Amendt , Frank Zenke
IPC分类号: A61K31/436 , C07D491/052
CPC分类号: C07D491/04
摘要: Compounds of the formula (I), in which R1, R2, R3, R4, R5, X, Y, W, Q1, Q2, Z, s and m have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumors.
摘要翻译: 式(I)的化合物,其中R 1,R 2,R 3,R 4,R 5,X,Y,W,Q 1,Q 2,Z,s和m具有权利要求1所示的含义, 用于治疗肿瘤。
-
公开(公告)号:US08410143B2
公开(公告)日:2013-04-02
申请号:US12488191
申请日:2009-06-19
申请人: Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人: Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号: A61K31/4412 , C07D213/68
CPC分类号: C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
-
公开(公告)号:US08110583B2
公开(公告)日:2012-02-07
申请号:US11917283
申请日:2006-05-31
申请人: Wolfgang Staehle , David Bruge , Kai Schiemann , Dirk Finsinger , Hans-Peter Buchstaller , Frank Zenke , Christiane Amendt
发明人: Wolfgang Staehle , David Bruge , Kai Schiemann , Dirk Finsinger , Hans-Peter Buchstaller , Frank Zenke , Christiane Amendt
IPC分类号: A61K31/473 , C07D221/06
CPC分类号: C07D491/04 , C07D221/16
摘要: Compounds of the formula I, in which s, k, I, W, R1, R2, R3, and U have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译: 其中s,k,I,W,R 1,R 2,R 3和U具有权利要求1所示含义的式I化合物可用于治疗肿瘤。
-
-
-
-
-
-
-
-
-