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    IVIG modulation of chemokines for treatment of multiple sclerosis, alzheimer's disease, and parkinson's disease
    4.
    发明授权
    IVIG modulation of chemokines for treatment of multiple sclerosis, alzheimer's disease, and parkinson's disease 有权
    用于治疗多发性硬化，阿尔茨海默氏病和帕金森病的趋化因子的IVIG调节

    公开(公告)号：US07968293B2

    公开(公告)日：2011-06-28

    申请号：US12189367

    申请日：2008-08-11

    申请人： Birgit Reipert ,  Hartmut Ehrlich ,  Hans-Peter Schwarz ,  Irina Elovaara

    发明人： Birgit Reipert ,  Hartmut Ehrlich ,  Hans-Peter Schwarz ,  Irina Elovaara

    IPC分类号： C12Q1/68 ,  G01N33/50

    CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to be overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.

    摘要翻译： 本发明提供用于提供治疗与脑炎性疾病相关疾病（包括MS）的预后的方法，例如使用显示为过表达的分子标记物复发性缓解多发性硬化（RRMS），阿尔茨海默氏病和帕金森病 或在静脉注射免疫球蛋白（IVIG）治疗的患者中未表达。 还提供了鉴定可用于治疗或预防MS的化合物的方法，例如复发缓解多发性硬化症（RRMS），阿尔茨海默病和帕金森病。

    Detection of antibody that binds to water soluble polymer-modified polypeptides
    9.
    发明授权
    Detection of antibody that binds to water soluble polymer-modified polypeptides 有权
    检测结合水溶性聚合物修饰多肽的抗体

    公开(公告)号：US08216793B2

    公开(公告)日：2012-07-10

    申请号：US12786641

    申请日：2010-05-25

    申请人： Christian Lubich ,  Juergen Siekmann ,  Birgit Maria Reipert ,  Hans-Peter Schwarz ,  Hartmut Ehrlich

    发明人： Christian Lubich ,  Juergen Siekmann ,  Birgit Maria Reipert ,  Hans-Peter Schwarz ,  Hartmut Ehrlich

    IPC分类号： G01N33/566

    CPC分类号： G01N33/6854

    摘要： The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.

    摘要翻译： 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合，其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇，聚唾液酸，葡聚糖，羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时，用非线性聚乙二醇衍生物修饰载体。