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![Pyrano [3,2-D][1,3]thiazole as glycosidase inhibitors](/abs-image/US/2014/11/11/US08884023B2/abs.jpg.150x150.jpg)
公开(公告)号：US08884023B2
公开(公告)日：2014-11-11
申请号：US14131471
申请日：2012-08-22
IPC分类号： C07D513/04 , A61K31/429 , A61K31/454 , A61K31/4439
CPC分类号： C07D513/04 , A61K31/429 , A61K31/4439 , A61K31/454
摘要： Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.
摘要翻译： 式（I）的新化合物，其中R 1至R 4和X具有权利要求所述的含义，其为葡糖苷酶抑制剂，并且可用于治疗阿尔茨海默氏病。
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![Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors](/abs-image/US/2014/08/28/US20140243370A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140243370A1
公开(公告)日：2014-08-28
申请号：US14131471
申请日：2012-08-22
IPC分类号： A61K31/4439 , A61K31/429 , A61K31/454 , C07D513/04
CPC分类号： C07D513/04 , A61K31/429 , A61K31/4439 , A61K31/454
摘要： Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.
摘要翻译： 式（I）的新化合物，其中R 1至R 4和X具有权利要求所述的含义，其为葡糖苷酶抑制剂，并且可用于治疗阿尔茨海默氏病。
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公开(公告)号：US20140107156A1
公开(公告)日：2014-04-17
申请号：US14105974
申请日：2013-12-13
申请人： Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号： C07D215/04 , A61K31/47
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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4.发明授权Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity 有权用BTK抑制活性生产嘧啶和吡啶化合物的组合物和方法公开(公告)号：US09073947B2
公开(公告)日：2015-07-07
申请号：US14112428
申请日：2012-06-10
申请人： Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
发明人： Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
IPC分类号： A61K31/506 , C07D401/12 , C07F5/02 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07D405/14 , C07D451/02 , C07D471/10
CPC分类号： A61K31/69 , A61K31/44 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/55 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/10 , C07D495/04 , C07F5/022
摘要： The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
摘要翻译： 本发明提供了式（I），式（II），式（III），式（IV）和式（V））的新型嘧啶和吡啶化合物用于治疗过度增殖性疾病的制造和用途，包括但不限于 癌症，狼疮，过敏性疾病，干燥病和类风湿性关节炎。 在优选的实施方案中，本发明描述不可逆激酶抑制剂，包括但不限于Bruton酪氨酸激酶的抑制剂。
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公开(公告)号：US08637532B2
公开(公告)日：2014-01-28
申请号：US13148903
申请日：2010-02-04
申请人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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6.发明申请Compositions and Methods for the Production of Pyrimidine and Pyridine Compounds with BTK Inhibitory Activity 有权用于生产具有BTK抑制活性的嘧啶和吡啶化合物的组合物和方法公开(公告)号：US20140162983A1
公开(公告)日：2014-06-12
申请号：US14112428
申请日：2012-06-10
申请人： Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
发明人： Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
IPC分类号： C07F5/02 , C07D413/12 , C07D401/12 , C07D403/12 , C07D239/47 , C07D403/14 , C07D403/04 , C07D401/04 , C07D451/02 , C07D405/14 , C07D413/14 , C07D401/14 , C07D471/10 , C07D239/48
CPC分类号： A61K31/69 , A61K31/44 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/55 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/10 , C07D495/04 , C07F5/022
摘要： The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
摘要翻译： 本发明提供了式（I），式（II），式（III），式（IV）和式（V））的新型嘧啶和吡啶化合物用于治疗过度增殖性疾病的制造和用途，包括但不限于 癌症，狼疮，过敏性疾病，干燥病和类风湿性关节炎。 在优选的实施方案中，本发明描述不可逆激酶抑制剂，包括但不限于Bruton酪氨酸激酶的抑制剂。
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公开(公告)号：US20120046269A1
公开(公告)日：2012-02-23
申请号：US13148903
申请日：2010-02-04
申请人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号： A61K31/517 , C07D401/12 , A61K31/4709 , C07D405/12 , C07D409/12 , C07D403/12 , C07D401/04 , C07D413/12 , A61K31/5377 , C07D413/04 , C07D401/14 , C07D417/12 , C07D413/14 , C07D409/10 , C07D471/04 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P17/00 , A61P9/00 , A61P17/06 , A61P3/10 , A61P27/02 , C07D239/94
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US20130184314A1
公开(公告)日：2013-07-18
申请号：US13785120
申请日：2013-03-05
IPC分类号： C07D213/82
CPC分类号： C07D213/82 , C07D213/79 , C07D213/81
摘要： The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.
摘要翻译： 本发明提供根据式（I）的新化合物，其用于治疗过度增生性疾病如癌症，再狭窄和炎症的制备和用途。
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公开(公告)号：US08889719B2
公开(公告)日：2014-11-18
申请号：US13785120
申请日：2013-03-05
IPC分类号： A61K31/455 , C07D213/46 , C07D213/82 , C07D213/79 , C07D213/81
CPC分类号： C07D213/82 , C07D213/79 , C07D213/81
摘要： The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.
摘要翻译： 本发明提供根据式（I）的新化合物，其用于治疗过度增生性疾病如癌症，再狭窄和炎症的制备和用途。
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公开(公告)号：US08404725B2
公开(公告)日：2013-03-26
申请号：US13057052
申请日：2009-07-27
IPC分类号： A61K31/455 , C07D213/46
CPC分类号： C07D213/82 , C07D213/79 , C07D213/81
摘要： The invention provides novel substituted phenylamino isonicotinamide compounds (I), pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined in the specification. Said compounds are MEK inhibitors useful in the treatment of hyperproliferative diseases related to the hyperactivity of MEK, such as restenosis, as well as diseases modulated by the MEK cascade, such as cancer and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的苯基氨基异烟酰胺化合物（I），其药学上可接受的盐，溶剂合物或前药，其中X，R 1，R 2，R 3，R 4，R 5和R 6如说明书中所定义。 所述化合物是可用于治疗与MEK的多动症相关的过度增生性疾病的MEK抑制剂，例如再狭窄，以及由MEK级联调节的疾病，例如癌症和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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