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1.发明申请Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form 有权使用六聚体形式的黄病毒NS1蛋白具有高亲和力的抗体来测定黄病毒感染的检测公开(公告)号：US20050186562A1
公开(公告)日：2005-08-25
申请号：US11017048
申请日：2004-12-21
申请人： Marie Flamand , Francoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Francoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
IPC分类号： A61K39/00 , A61K39/12 , A61K39/395 , A61K48/00 , A61P31/14 , C07K14/18 , C07K16/10 , C12N15/09 , C12P21/02 , G01N33/543 , G01N33/569 , G01N33/577 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immumological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及用于早期检测黄病毒诱导的感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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公开(公告)号：US20090226478A1
公开(公告)日：2009-09-10
申请号：US11892283
申请日：2007-08-21
申请人： Marie Flamand , Francoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Francoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
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3.发明授权Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form 有权使用六聚体形式的黄病毒NS1蛋白具有高亲和力的抗体来测定黄病毒感染的检测公开(公告)号：US06870032B1
公开(公告)日：2005-03-22
申请号：US09980839
申请日：2000-06-09
申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
IPC分类号： A61K39/00 , A61K39/12 , A61K39/395 , A61K48/00 , A61P31/14 , C07K14/18 , C07K16/10 , C12N15/09 , C12P21/02 , G01N33/543 , G01N33/569 , G01N33/577 , C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及一种用于早期检测黄病毒感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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4.发明授权Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirusi in hexameric form 有权使用对六聚体形式的黄病毒的NS1蛋白具有高亲和力的抗体来测定黄病毒感染的诊断公开(公告)号：US08709427B2
公开(公告)日：2014-04-29
申请号：US13190547
申请日：2011-07-26
申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及一种用于早期检测黄病毒感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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5.发明申请公开(公告)号：US20120009216A1
公开(公告)日：2012-01-12
申请号：US13190547
申请日：2011-07-26
申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及一种用于早期检测黄病毒感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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公开(公告)号：US07670766B2
公开(公告)日：2010-03-02
申请号：US11898293
申请日：2007-09-11
申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及一种用于早期检测黄病毒感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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7.发明授权Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form 有权使用六聚体形式的黄病毒NS1蛋白具有高亲和力的抗体来测定黄病毒感染的检测公开(公告)号：US07282341B2
公开(公告)日：2007-10-16
申请号：US11017048
申请日：2004-12-21
申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immumological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及用于早期检测黄病毒诱导的感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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公开(公告)号：US08715693B2
公开(公告)日：2014-05-06
申请号：US13423161
申请日：2012-03-16
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US20120266261A1
公开(公告)日：2012-10-18
申请号：US13423161
申请日：2012-03-16
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
IPC分类号： C12N7/00 , C12N5/10 , C12N15/40 , A01K67/027 , C07H21/04 , C07K14/18 , C07K16/10 , C12N15/85 , C12Q1/70
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US07390495B2
公开(公告)日：2008-06-24
申请号：US10956085
申请日：2004-10-04
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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