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1.发明申请公开(公告)号：US20050158784A1
公开(公告)日：2005-07-21
申请号：US11034277
申请日：2005-01-12
申请人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
发明人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P25/14 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C12Q1/6883 , G01N33/68 , C07H21/04
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/705 , C07K16/28 , C12N2799/021 , C12Q2600/156 , C12Q2600/158 , G01N33/68
摘要： The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.
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2.发明申请Nucleic acids of the human ABCC12 gene, vectors containing such nucleic acids and uses thereof 审中-公开人ABCC12基因的核酸，含有该核酸的载体及其用途公开(公告)号：US20060063166A1
公开(公告)日：2006-03-23
申请号：US11014147
申请日：2004-12-16
申请人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
发明人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
CPC分类号： C12Q1/6876 , C07K14/705 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to a novel human ABCC12 gene as well as the cDNAs encoding the novel short and long of ABCC12 proteins isoforms. The invention also relates to vectors and recombinant host cells comprising such nucleic acids, nucleotide probes and primers, and means for the detection of polymorphisms and mutations in the ABCC12 gene or in the corresponding proteins isoforms produced by the allelic form of the ABCC12 gene.
摘要翻译： 本发明涉及一种新的人ABCC12基因以及编码ABCC12蛋白新型短类型的cDNA。 本发明还涉及包含这种核酸，核苷酸探针和引物的载体和重组宿主细胞，以及用于检测ABCC12基因或ABCC12基因等位基因产生的相应蛋白质亚型的多态性和突变的方法。
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3.发明授权Nucleic acids of the human ABCC11 gene, vectors containing such nucleic acids and uses thereof 有权人ABCC11基因的核酸，含有该核酸的载体及其用途公开(公告)号：US06893841B2
公开(公告)日：2005-05-17
申请号：US10087782
申请日：2002-03-05
申请人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
发明人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P25/14 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/68 , C12N15/12 , C07K14/47 , C12P21/02
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/705 , C07K16/28 , C12N2799/021 , C12Q2600/156 , C12Q2600/158 , G01N33/68
摘要： The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.
摘要翻译： 本发明涉及对应于ABCC11基因的各种外显子的核酸以及编码新的全长ABCC11蛋白的cDNA。 本发明还涉及通常检测多态性的方法，特别是在ABCC11基因或由ABCC11基因的等位基因形成的相应蛋白质中的突变。
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4.发明授权Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses 有权ABC1基因的调控核酸，修饰其活性和治疗用途的分子公开(公告)号：US07378274B2
公开(公告)日：2008-05-27
申请号：US09846456
申请日：2001-05-02
申请人： Marie-Françoise Rosier-Montus , Catherine Prades , Cendrine Lemoine , Laurent Naudin , Patrice Denefle , Nicolas Duverger , Bryan Brewer , Alan Remaley , Sylvia Santamarina-Fojo
发明人： Marie-Françoise Rosier-Montus , Catherine Prades , Cendrine Lemoine , Laurent Naudin , Patrice Denefle , Nicolas Duverger , Bryan Brewer , Alan Remaley , Sylvia Santamarina-Fojo
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , G01N2500/10
摘要： The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.
摘要翻译： 本发明涉及一种能够调节ABC1基因转录的核酸，该ABC1基因是与胆固醇代谢功能异常有关的病理学的致病基因，诱导诸如动脉粥样硬化的疾病。 本发明还涉及包含编码感兴趣的多肽或核酸的多核苷酸的核苷酸构建体，其在控制下置于ABC1基因的调控核酸上。 本发明还涉及重组载体，转化宿主细胞和非人类转基因哺乳动物，其包含调节ABC1基因或上述核苷酸构建体的转录的核酸，以及用于筛选能够改变活性的分子或物质的方法 ABC1基因的调控核酸。
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公开(公告)号：US08273548B2
公开(公告)日：2012-09-25
申请号：US11390195
申请日：2006-03-28
申请人： Han Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
发明人： Han Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
摘要翻译： 本发明涉及新化合物及其用途，特别是其药物或诊断用途或其作为药理学靶标的用途。 更具体地，本发明涉及一种称为PAP1的新型蛋白质，以及能够至少部分调节帕金蛋白酶活性的新型肽和化合物。
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公开(公告)号：US20060287230A1
公开(公告)日：2006-12-21
申请号：US11390195
申请日：2006-03-28
申请人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Francoise Rosier-Montus , Olga Corti
发明人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Francoise Rosier-Montus , Olga Corti
IPC分类号： A61K38/17 , A61K39/395 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
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公开(公告)号：US07132396B2
公开(公告)日：2006-11-07
申请号：US09785548
申请日：2001-02-20
申请人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
发明人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
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公开(公告)号：US20130039912A1
公开(公告)日：2013-02-14
申请号：US13641012
申请日：2011-04-08
申请人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
发明人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
IPC分类号： A61K39/395 , C07H21/04 , A61P35/00 , C07K19/00
CPC分类号： C07K14/475
摘要： The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also relates to a composition including such a recombinant Another aspect of the invention involves using a Robo1-Fc molecule as a diagnostic tool for detecting the overexpression of a molecule belonging to the Slit family in a patient.
摘要翻译： 本发明涉及Robo1-Fc重组蛋白及其用于治疗其中Slit蛋白被过度表达的疾病，特别是癌症的用途。 本发明还涉及包含这种重组的组合物本发明的另一方面涉及使用Robo1-Fc分子作为用于检测患者中属于Slit家族的分子的过表达的诊断工具。
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公开(公告)号：US09493529B2
公开(公告)日：2016-11-15
申请号：US13641012
申请日：2011-04-08
申请人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
发明人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
IPC分类号： C07K14/475
CPC分类号： C07K14/475
摘要： The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also relates to a composition including such a recombinant protein. Another aspect of the invention involves using a Robo1-Fc molecule as a diagnostic tool for detecting the overexpression of a molecule belonging to the Slit family in a patient.
摘要翻译： 本发明涉及Robo1-Fc重组蛋白及其用于治疗其中Slit蛋白被过度表达的疾病，特别是癌症的用途。 本发明还涉及包含这种重组蛋白的组合物。 本发明的另一方面涉及使用Robo1-Fc分子作为用于检测患者中属于Slit家族的分子的过表达的诊断工具。
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