-
1.发明申请Novel derivatives of 4,4' dithiobis-(3-aminobutane-1-1-sulfonates) and compositions comprising the same 有权4,4'-二硫代双（3-氨基丁烷-1-磺酸盐）的新衍生物和包含它们的组合物公开(公告)号：US20060205695A1
公开(公告)日：2006-09-14
申请号：US10567362
申请日：2004-08-06
申请人： Bernard Roques , Nicolas Inguimbert , Marie-Claude Fournie-Zaluski , Pierre Corvol , Catherine Llorens-Cortes
发明人： Bernard Roques , Nicolas Inguimbert , Marie-Claude Fournie-Zaluski , Pierre Corvol , Catherine Llorens-Cortes
IPC分类号： A61K31/185 , A61K31/66 , C07F9/22 , C07C323/30
CPC分类号： C07C323/66 , C07F9/30 , C07F9/32
摘要： The invention relates to derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.
摘要翻译： 本发明涉及用于治疗和预防原发性和继发性动脉高血压的式（1）的4,4'-二硫代双（3-氨基丁烷-1-磺酸盐）的衍生物。
-
2.发明申请Novel derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulfphonates) and compositions containing same 有权4,4'-二硫代双（3-氨基丁烷-1-磺酸盐）的新衍生物和含有它们的组合物公开(公告)号：US20060135602A1
公开(公告)日：2006-06-22
申请号：US10521171
申请日：2003-07-16
IPC分类号： A61K31/255 , A61K31/185
CPC分类号： C07C323/66
摘要： The invention relates to the bis-hydrochloride of 4,4′-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4′-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.
摘要翻译： 本发明涉及4,4'-二硫代双（3-氨基丁烷-1-磺酸钠）双 - 盐酸盐和2,4'-二硫代双 - （3-氨基丁烷-1-磺酸钠， 2-二甲基丙基）。 本发明还涉及包含所述化合物之一以及所述化合物之一用于制备药物的药物组合物。 本发明适用于高血压和间接或直接相关疾病的治疗方法。
-
3.发明授权Derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) and compositions comprising the same 有权4,4'-二硫代双（3-氨基丁烷-1-磺酸盐）的衍生物和包含它们的组合物公开(公告)号：US07582797B2
公开(公告)日：2009-09-01
申请号：US10567362
申请日：2004-08-06
申请人： Bernard Pierre Roques , Nicolas Inguimbert , Marie-Claude Fournie-Zaluski , Pierre Corvol , Catherine Llorens-Cortes
发明人： Bernard Pierre Roques , Nicolas Inguimbert , Marie-Claude Fournie-Zaluski , Pierre Corvol , Catherine Llorens-Cortes
IPC分类号： C07C321/14
CPC分类号： C07C323/66 , C07F9/30 , C07F9/32
摘要： The invention relates to derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.
摘要翻译： 本发明涉及用于治疗和预防原发性和继发性动脉高血压的式（1）的4,4'-二硫代双（3-氨基丁烷-1-磺酸盐）的衍生物。
-
4.发明授权Derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfphonates) and compositions containing same 有权4,4'-二硫代双（3-氨基丁烷-1-磺酸盐）的衍生物和含有它们的组合物公开(公告)号：US07235687B2
公开(公告)日：2007-06-26
申请号：US10521171
申请日：2003-07-16
申请人： Marie-Claude Fournie-Zaluski , Catherine Llorens-Cortes , Bernard Pierre Roques , Pierre Corvol
发明人： Marie-Claude Fournie-Zaluski , Catherine Llorens-Cortes , Bernard Pierre Roques , Pierre Corvol
IPC分类号： C07C309/00 , A61K31/255 , A61K31/185
CPC分类号： C07C323/66
摘要： The invention relates to the bis-hydrochloride of 4,4′-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4′-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.
摘要翻译： 本发明涉及4,4'-二硫代双（3-氨基丁烷-1-磺酸钠）双 - 盐酸盐和2,4'-二硫代双 - （3-氨基丁烷-1-磺酸钠， 2-二甲基丙基）。 本发明还涉及包含所述化合物之一以及所述化合物之一用于制备药物的药物组合物。 本发明适用于高血压和间接或直接相关疾病的治疗方法。
-
5.发明授权Pharmaceutical composition comprising at least one aminopeptidase A inhibitor 有权包含至少一种氨基肽酶A抑制剂的药物组合物公开(公告)号：US06340708B1
公开(公告)日：2002-01-22
申请号：US09600238
申请日：2000-08-22
申请人： Catherine Llorens-Cortes , Pierre Corvol , Marie-Claude Fournié-Zaluski , Bernard Pierre Roques
发明人： Catherine Llorens-Cortes , Pierre Corvol , Marie-Claude Fournié-Zaluski , Bernard Pierre Roques
IPC分类号： A61K31185
CPC分类号： A61K31/415 , A61K31/00 , A61K31/185 , A61K2300/00
摘要： The invention relates primarily to a pharmaceutical composition which can be used for lowering arterial blood pressure and is characterized in that it contains as active ingredient at least one selective aminopeptidase A inhibitor. Said inhibitor can notably be (S) 3-amino-4-mercaptobutyl sulfonic acid or one of its salts.
摘要翻译： 本发明主要涉及可用于降低动脉血压的药物组合物，其特征在于其含有至少一种选择性氨基肽酶A抑制剂作为活性成分。 所述抑制剂可显着地为（S）3-氨基-4-巯基丁基磺酸或其盐之一。
-
公开(公告)号：US5763168A
公开(公告)日：1998-06-09
申请号：US319545
申请日：1994-10-07
申请人： Jean-Marc Lalouel , Xavier Jeunemaitre , Richard P. Lifton , Florent Soubrier , Youri Kotelevtsev , Pierre Corvol
发明人： Jean-Marc Lalouel , Xavier Jeunemaitre , Richard P. Lifton , Florent Soubrier , Youri Kotelevtsev , Pierre Corvol
CPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
-
公开(公告)号：US5589584A
公开(公告)日：1996-12-31
申请号：US269766
申请日：1994-07-01
申请人： Jean-Marc Lalouel , Xavier Jeunemaitre , Richard P. Lifton , Florent Soubrier , Youri Kotelevtsev , Pierre Corvol
发明人： Jean-Marc Lalouel , Xavier Jeunemaitre , Richard P. Lifton , Florent Soubrier , Youri Kotelevtsev , Pierre Corvol
CPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： The association of molecular variants of the angiotensinogen gene with human essential hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
摘要翻译： 公开了血管紧张素原基因的分子变体与人原发性高血压的关联。 确定这种关联使得能够筛选出具有高血压倾向的人。
-
8.发明授权N-terminal site selective inhibitors of human angiotensin conversion enzyme (ACE) 失效人血管紧张素转换酶（ACE）的N-末端位点选择性抑制剂公开(公告)号：US06482797B1
公开(公告)日：2002-11-19
申请号：US09719573
申请日：2001-01-30
申请人： Vincent Dive , Joël Cotton , Philippe Cuniasse , Athanasios Yiotakis , Pierre Corvol , Annie Michaud , Marie-Thérèse Chauvet , Joël Menard , Eric Ezan
发明人： Vincent Dive , Joël Cotton , Philippe Cuniasse , Athanasios Yiotakis , Pierre Corvol , Annie Michaud , Marie-Thérèse Chauvet , Joël Menard , Eric Ezan
IPC分类号： A61K3800
摘要： The invention relates to peptide derivatives that can be used as selective inhibitors of the N-terminal site of human angiotensin-converting enzyme. The derivatives comprise the amino acid sequence with the following formula: -Asp-Phe-&PSgr;(PO2CH2)-Ala-Xaa′- (I) wherein: &PSgr;(PO2CH2) indicates that the peptide bond (CONH) between Phe and Ala has been replaced by the phosphonic bond PO2CH2, and Xaa′ represents an amino acid residue. They can be used in pharmaceutical formulations, particularly to protect haematopoietic strain cells of patients undergoing aggressive chemotherapy or radiotherapy treatment.
摘要翻译： 本发明涉及可用作人血管紧张素转换酶的N-末端位点的选择性抑制剂的肽衍生物。该衍生物包含具有下式的氨基酸序列：其中：＆amp; PSgr;（PO2CH2）表示肽键 Phe和Ala之间的（CONH）已被膦酸键PO2CH2代替，Xaa'代表氨基酸残基。它们可用于药物制剂，特别是用于保护接受侵袭性化疗或放疗治疗的患者的造血细胞株。
-
公开(公告)号：US6165727A
公开(公告)日：2000-12-26
申请号：US429034
申请日：1999-10-29
申请人： Jean-Marc Lalouel , Xavier Jeunemaitre , Richard P. Lifton , Florent Soubrier , Youri Kotelevtsev , Pierre Corvol
发明人： Jean-Marc Lalouel , Xavier Jeunemaitre , Richard P. Lifton , Florent Soubrier , Youri Kotelevtsev , Pierre Corvol
CPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
摘要翻译： 公开了血管紧张素原基因的分子变体G-6A与人高血压的关联。 确定这种关联使得能够筛选出具有高血压倾向的人。
-
10.发明授权Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension 失效编码人血管紧张素转换酶（ACE）的核酸及其用途，特别是动脉高压的体外诊断
公开(公告)号：US5480793A
公开(公告)日：1996-01-02
申请号：US288709
申请日：1994-08-12
IPC分类号： C12N15/09 , A61K38/00 , C07K16/40 , C12N7/00 , C12N9/48 , C12N9/64 , C12N15/16 , C12N15/57 , C12P21/08 , C12Q1/68 , C12N1/21 , C12N15/63 , C12P21/02
CPC分类号： C12Q1/6827 , C07K16/40 , C12N9/48 , C12Q1/683 , C12Q1/6883 , A61K38/00 , C12Q2600/156
摘要： The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.
摘要翻译： 本发明涉及编码人ACE的核酸的克隆和测序，以及对应于ACE的肽链和从其衍生的活性肽片段的测定。 本发明的另一主题是利用上述多肽来实施高血压的体外诊断方法和设计ACE的新抑制剂。 本发明还涉及本发明的核苷酸探针用于体外筛选编码ACE的基因的多态性的用途。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.021 秒)
