-
公开(公告)号:US20060242724A1
公开(公告)日:2006-10-26
申请号:US11385261
申请日:2006-03-20
申请人: Mark Carlton , John Dixon , Alan Hendrick , Sophie Messager , Dirk Zahn , Jennifer Horwood
发明人: Mark Carlton , John Dixon , Alan Hendrick , Sophie Messager , Dirk Zahn , Jennifer Horwood
IPC分类号: A01K67/027 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0312 , A01K2267/0356 , A61K38/00 , C07K14/705 , C07K14/70571 , G01N33/57407 , G01N33/6893 , G01N33/6896 , G01N33/92 , G01N2500/00 , G01N2800/042 , G01N2800/046 , G01N2800/067 , G01N2800/28 , G01N2800/2821 , G01N2800/2835 , G01N2800/2842 , G01N2800/2857 , G01N2800/2864
摘要: The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a sphingosylphosphorylcholine receptor and/or ligands thereof in the manipulation of the neuronal and limbic systems and diagnosis and treatment of pain.
摘要翻译: 本发明涉及已知受体的新功能。 特别地,本发明涉及鞘氨醇磷酰胆碱受体和/或其配体在神经元和边缘系统的操作中的用途以及疼痛的诊断和治疗。
-
公开(公告)号:US07879564B2
公开(公告)日:2011-02-01
申请号:US11644011
申请日:2006-12-21
申请人: Nicola Brice , Mark Carlton , John Dixon , Alan Hendrick , Isabelle Malinge , Sophie Messager , Dirk Zahn
发明人: Nicola Brice , Mark Carlton , John Dixon , Alan Hendrick , Isabelle Malinge , Sophie Messager , Dirk Zahn
IPC分类号: G01N33/53 , G01N33/566
CPC分类号: G01N33/566 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K49/0008 , C07K14/70571 , C12N15/8509 , G01N33/6893 , G01N2333/726 , G01N2500/00 , G01N2800/24 , G01N2800/52
摘要: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.
摘要翻译: 我们描述了鉴定适于治疗,预防或减轻GPR86相关疾病,特别是炎性疾病或疼痛的分子的方法,该方法包括确定候选分子是否是GPR86多肽的激动剂或拮抗剂,其中GPR86 多肽包含SEQ ID NO:3或SEQ ID NO:5或SEQ ID NO:7所示的氨基酸序列,其片段或与其至少90%相同的序列。
-
公开(公告)号:US20070248545A1
公开(公告)日:2007-10-25
申请号:US11644011
申请日:2006-12-21
申请人: Nicola Brice , Mark Carlton , John Dixon , Alan Hendrick , Isabelle Malinge , Sophie Messager , Dirk Zahn
发明人: Nicola Brice , Mark Carlton , John Dixon , Alan Hendrick , Isabelle Malinge , Sophie Messager , Dirk Zahn
CPC分类号: G01N33/566 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K49/0008 , C07K14/70571 , C12N15/8509 , G01N33/6893 , G01N2333/726 , G01N2500/00 , G01N2800/24 , G01N2800/52
摘要: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.
摘要翻译: 我们描述了鉴定适于治疗,预防或减轻GPR86相关疾病,特别是炎性疾病或疼痛的分子的方法,该方法包括确定候选分子是否是GPR86多肽的激动剂或拮抗剂,其中GPR86 多肽包含SEQ ID NO:3或SEQ ID NO:5或SEQ ID NO:7所示的氨基酸序列,其片段或与其至少90%相同的序列。
-
公开(公告)号:US20100158807A1
公开(公告)日:2010-06-24
申请号:US12575034
申请日:2009-10-07
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
CPC分类号: C07K14/705
摘要: We disclose a method of treating or preventing a disease selected from the group consisting of: a bladder disease, a bladder disorder, benign prostatic hyperplasia, bladder outlet obstruction, incontinence, including overflow and urge incontinence, urinary urge, cystitis, including interstitial cystitis and overactive bladder.
摘要翻译: 我们公开了一种治疗或预防选自以下的疾病的方法:膀胱疾病,膀胱病,良性前列腺增生,膀胱出口阻塞,失禁,包括溢流和急迫性尿失禁,尿急,膀胱炎,包括间质性膀胱炎和 膀胱过度活动
-
公开(公告)号:US20100272647A1
公开(公告)日:2010-10-28
申请号:US12612267
申请日:2009-11-04
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
CPC分类号: C07K14/705
摘要: We disclose BACH G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof Nucleic acids capable of encoding BACH polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4 or a mouse BACH genomic sequence (SEQ ID NO: 10).
摘要翻译: 我们公开了包含SEQ ID NO:1所示氨基酸序列的BACH G蛋白偶联受体(GPCR)多肽。 3或SEQ ID NO:5及其同源物,变体和衍生物还能够公开能够编码BACH多肽的核酸,特别是包含SEQ ID No.1,SEQ ID No.2或SEQ所示的核酸序列的核酸 SEQ ID NO:4或小鼠BACH基因组序列(SEQ ID NO:10)。
-
公开(公告)号:US20050160486A1
公开(公告)日:2005-07-21
申请号:US10900930
申请日:2004-07-27
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
IPC分类号: C07K14/705 , A01K67/027 , A61K38/17 , A61K39/395 , A61K48/00
CPC分类号: C07K14/705
摘要: We disclose a method of treating or preventing a disease selected from the group consisting of: a bladder disease, a bladder disorder, benign prostatic hyperplasia, bladder outlet obstruction, incontinence, including overflow and urge incontinence, urinary urge, cystitis, including interstitial cystitis and overactive bladder.
摘要翻译: 我们公开了一种治疗或预防选自以下的疾病的方法:膀胱疾病,膀胱病,良性前列腺增生,膀胱出口阻塞,失禁,包括溢流和急迫性尿失禁,尿急,膀胱炎,包括间质性膀胱炎和 膀胱过度活动
-
公开(公告)号:US20070166230A1
公开(公告)日:2007-07-19
申请号:US11590175
申请日:2006-10-30
申请人: Nicola Brice , Mark Carlton , John Dixon , Isabelle Malinge , Dirk Zahn
发明人: Nicola Brice , Mark Carlton , John Dixon , Isabelle Malinge , Dirk Zahn
IPC分类号: A61K49/00 , G01N33/567
CPC分类号: A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K49/0008 , C07K14/705 , C12N15/8509 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/301
摘要: Provided are Kv9.2 polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Kv9.2 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4. Methods of identifying Kv9.2 agonists and antagonists are also provided.
摘要翻译: 提供了包含SEQ ID NO:1所示氨基酸序列的Kv9.2多肽。 3或SEQ ID NO:5,及其同源物,变体和衍生物。 还公开了能够编码Kv9.2多肽的核酸,特别是包含SEQ ID No.1,SEQ ID No.2或SEQ ID NO:4所示的核酸序列的核酸。鉴定Kv9.2激动剂和 还提供拮抗剂。
-
公开(公告)号:US20050026825A1
公开(公告)日:2005-02-03
申请号:US10714161
申请日:2003-11-14
申请人: Mark Carlton , Samuel Aparicio , John Dixon , Rosemary Thresher , Dirk Zahn
发明人: Mark Carlton , Samuel Aparicio , John Dixon , Rosemary Thresher , Dirk Zahn
IPC分类号: A61K48/00 , C07K14/72 , C12N15/12 , A01K67/00 , A01K67/027 , C07H21/04 , C07K14/705
CPC分类号: C07K14/723 , A61K48/00
摘要: We disclose Mowgli G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 6 or SEQ ID NO: 8, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Mowgli polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7 or SEQ ID NO: 10.
摘要翻译: 我们公开了包含SEQ ID NO:3,SEQ ID NO:5,SEQ ID NO:6或SEQ ID NO:8所示氨基酸序列的Mowgli G蛋白偶联受体(GPCR)多肽及其同源物,变体和衍生物 。 还公开了能够编码Mowgli多肽的核酸,特别是包含SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:4,SEQ ID NO:7或SEQ ID NO: 10。
-
公开(公告)号:US20090187996A1
公开(公告)日:2009-07-23
申请号:US11926693
申请日:2007-10-29
申请人: Nicola Brice , Mark Carlton , John Dixon , Isabelle Malinge , Dirk Zahn
发明人: Nicola Brice , Mark Carlton , John Dixon , Isabelle Malinge , Dirk Zahn
IPC分类号: G01N33/483 , G01N33/68 , A61K49/00 , C12Q1/68 , A01K67/027 , A01K67/00 , C07K14/47 , A61K39/395
CPC分类号: C07K14/705 , A61K49/0008
摘要: The present invention relates to a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of pain, the method comprising determining whether a candidate molecule is an agonist or antagonist, including a opener, blocker or modulator, of Kv9.2 polypeptide, in which the Kv9.2 polypeptide comprises the amino acid sequence shown in SEQ ID NO:3 or SEQ ID NO:5, or a sequence which is at least 90% identical thereto.
摘要翻译: 本发明涉及鉴定适于治疗,预防或缓解疼痛的分子的方法,所述方法包括确定候选分子是否是Kv9.2多肽的激动剂或拮抗剂,包括开启剂,阻断剂或调节剂, 其中Kv9.2多肽包含SEQ ID NO:3或SEQ ID NO:5所示的氨基酸序列,或与其至少90%相同的序列。
-
公开(公告)号:US20050064549A1
公开(公告)日:2005-03-24
申请号:US10826572
申请日:2004-04-16
申请人: Samuel Aparicio , Mark Carlton , Philip Mitchell
发明人: Samuel Aparicio , Mark Carlton , Philip Mitchell
IPC分类号: C07H21/04 , C07K14/705
CPC分类号: C07K14/705
摘要: We disclose Conrad G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 14 or SEQ ID NO: 17 and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Conrad polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 16 or SEQ ID NO: 18.
摘要翻译: 我们公开了包含SEQ ID NO:3,SEQ ID NO:5,SEQ ID NO:9,SEQ ID NO:11,SEQ ID NO:14或SEQ ID NO:14所示氨基酸序列的Conrad G-蛋白偶联受体(GPCR) 编号:17及其同系物,变体和衍生物。 还公开了能够编码Conrad多肽的核酸,特别是包含SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:4,SEQ ID NO:6,SEQ ID NO:6所示的核酸序列的核酸。 7,SEQ ID NO:8,SEQ ID NO:10,SEQ ID NO:12,SEQ ID NO:13,SEQ ID NO:15,SEQ ID NO:16或SEQ ID NO:18。
-
-
-
-
-
-
-
-
-