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    Vacuum loading of test sample cards in an analytical instrument
    3.
    发明授权
    Vacuum loading of test sample cards in an analytical instrument 失效
    测试样品卡在分析仪器中的真空加载

    公开(公告)号：US5965090A

    公开(公告)日：1999-10-12

    申请号：US6623

    申请日：1998-01-13

    申请人： Mark Joseph Fanning ,  Clifford W. Karl ,  Donald Meyer ,  William Ernest Seaton ,  Paul Springer ,  Craig Drager

    发明人： Mark Joseph Fanning ,  Clifford W. Karl ,  Donald Meyer ,  William Ernest Seaton ,  Paul Springer ,  Craig Drager

    IPC分类号： B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

    CPC分类号： B01L3/50 ,  G01N35/00029 ,  G01N1/38 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/00148 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.

    摘要翻译： 用于测试存储在测试卡中的样品的自动样品测试机。 该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。 该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。 移液站将流体从一个容器传送到另一个容器。 设置真空站，其具有可在上位置和下​​位置之间相对于托盘移动的真空室。 当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。 真空发生器为腔室提供真空。 当从室释放真空时，将流体样品从容器装载到卡中。 测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。 测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。 读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

    Stacking disposal system for test sample cards or other similarly shaped objects
    4.
    发明授权
    Stacking disposal system for test sample cards or other similarly shaped objects 失效
    用于测试样品卡或其他类似形状的物体的堆放处理系统

    公开(公告)号：US5674454A

    公开(公告)日：1997-10-07

    申请号：US604475

    申请日：1996-02-21

    申请人： Clifford W. Karl ,  Kent Smith ,  Arthur Rousmaniere ,  David Porat ,  Thomas Burchard ,  Gregg Flender

    发明人： Clifford W. Karl ,  Kent Smith ,  Arthur Rousmaniere ,  David Porat ,  Thomas Burchard ,  Gregg Flender

    IPC分类号： G01N35/00 ,  G01N35/10

    CPC分类号： G01N35/00029 ,  Y10S206/817 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/114165

    摘要： A disposal system for stacking card-like objects neatly in a magazine. The cards enter the disposal system via a card entrance slot. A push plate located adjacent the slot pushes the cards past a pair of resilient snap elements in the sides of the magazine. A pressure plate is located behind the snap elements and biases the cards that have been pushed over the snap elements forward towards the rear of the snap elements. The cards are maintained in a stacked condition between the snap elements and the pressure plate. When a card is inserted into the card slot, the push plate is operated to an extended position, in which it pushes the card past the snap elements against the cards stacked between the snap elements and the pressure plate. The push plate then retracts, so as to enable another card to enter into the card slot. The user of the machine removes the magazine from the machine when the need arises or when the magazine is fully loaded with cards.

    摘要翻译： 一种处理系统，用于将卡状物体整齐地堆放在杂志中。 卡通过卡片入口插槽进入处理系统。 位于狭​​槽附近的推板推动卡通过盒的侧面中的一对弹性卡扣元件。 压板位于卡扣元件后面并且偏压已经被推到卡扣元件上的卡片朝向卡扣元件的后部。 这些卡在卡扣元件和压力板之间保持堆叠状态。 当卡插入卡槽中时，推板被操作到延伸位置，在该延伸位置，卡将卡通过卡扣元件抵靠堆叠在卡扣元件和压板之间的卡片。 推板然后缩回，以使另一张卡进入卡槽。 当需要时或当杂志完全装满卡时，机器的用户将机器从机器上移除。

    Cutting and sealing station for test sample cards in an automated analytical system
    7.
    发明授权
    Cutting and sealing station for test sample cards in an automated analytical system 失效
    自动分析系统中测试样品卡的切割和封口站

    公开(公告)号：US5891396A

    公开(公告)日：1999-04-06

    申请号：US6617

    申请日：1998-01-13

    申请人： Clifford W. Karl ,  Ron Robinson

    发明人： Clifford W. Karl ,  Ron Robinson

    IPC分类号： B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/02

    CPC分类号： B01L3/50 ,  G01N35/00029 ,  G01N1/38 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/00148 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.

    摘要翻译： 用于测试存储在测试卡中的样品的自动样品测试机。 该机器具有测试样品定位系统，用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。 该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。 移液站将流体从一个容器传送到另一个容器。 设置真空站，其具有可在上位置和下​​位置之间相对于托盘移动的真空室。 当室下降到较低位置时，室与托盘配合以与托盘的顶表面进行密封接合。 真空发生器为腔室提供真空。 当从室释放真空时，将流体样品从容器装载到卡中。 测试样品定位系统将托盘移动到切割和密封站，然后移动到孵化站，并将卡一次装载到孵育站内的转盘中。 测试卡传输站将测试卡从孵化站运送到光学读取站，其中在卡的孔上进行光学测量（例如，透射率和/或荧光光学测试）。 读卡完成后，将其移回孵化站进行额外的孵化和阅读，或者将其转移到卡片处理系统。

    Incubation station for test sample cards
    8.
    发明授权
    Incubation station for test sample cards 失效

    公开(公告)号：US5998201A

    公开(公告)日：1999-12-07

    申请号：US905374

    申请日：1997-08-04

    申请人： Gregory R. Maes ,  Dennis M. Connor ,  Brent D. Freiner ,  Clifford W. Karl ,  Ron Robinson ,  Raymond M. Shelton ,  Garry R. Tegeler ,  Michael James Justin

    发明人： Gregory R. Maes ,  Dennis M. Connor ,  Brent D. Freiner ,  Clifford W. Karl ,  Ron Robinson ,  Raymond M. Shelton ,  Garry R. Tegeler ,  Michael James Justin

    摘要： An incubation station has a carousel for receiving a plurality of test sample cards. An even temperature and air flow distribution inside the carousel and incubation of the cards over time at the proper temperature was found to be critically dependent upon air flow characteristics within the incubation station. To optimize air flow, the carousel was given an open rear side that is exposed to an air distribution table having a cover plate placed adjacent to the rear surface of the carousel. The cover plate has a plurality of elongate slots positioned in a symmetrical ring-shaped pattern in registry with the carousel. The elongate slots are positioned at an angle relative to the slots in the carousel such that each carousel slot receives air from more than one slot. An extra fan was also added to the system to increase the flow of air into the air table. Scallop features on the carousel walls also promote even distribution of air flow over the cards. The carousel may be divided into a plurality of carousel segments to increase ease of removal and insertion of the carousel into the incubation station and manufacturability of the carousel.