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    Novel human histone deacetylases
    6.
    发明申请
    Novel human histone deacetylases 有权

    公开(公告)号：US20060269559A1

    公开(公告)日：2006-11-30

    申请号：US11497205

    申请日：2006-08-01

    申请人： Donald Jackson ,  Matthew Lorenzi ,  Ricardo Attar ,  Marco Gottardis

    发明人： Donald Jackson ,  Matthew Lorenzi ,  Ricardo Attar ,  Marco Gottardis

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C12N9/16

    摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

    Methods for identifying or screening for agents that modulate 17β-HSD3
    8.
    发明授权
    Methods for identifying or screening for agents that modulate 17β-HSD3 有权
    用于鉴定或筛选调节17β-HSD3的药剂的方法

    公开(公告)号：US07138246B2

    公开(公告)日：2006-11-21

    申请号：US11068606

    申请日：2005-02-28

    申请人： Matthew V. Lorenzi ,  Thomas Spires ,  Dan You ,  Roberto Weinmann ,  Marco Gottardis

    发明人： Matthew V. Lorenzi ,  Thomas Spires ,  Dan You ,  Roberto Weinmann ,  Marco Gottardis

    IPC分类号： G01N33/53 ,  G01N33/567

    CPC分类号： G01N33/743

    摘要： Methods for determining whether a test agent inhibits a 17β-HSD3, the methods comprising: obtaining a recombinant host cell that expresses the 17β-HSD3; obtaining a reaction mixture comprising the 17β-HSD3, androstenedione, and the test agent; measuring the amount of testosterone in the reaction mixture by a scintillation proximity assay (SPA) using SPA beads conjugated with a testosterone-specific antibody, wherein when the amount of testosterone is lower in the presence of a test agent than in the absence of the test agent, the test agent is identified as an inhibitor of the 17β-HSD3.

    摘要翻译： 用于确定测试试剂是否抑制17β-HSD3的方法，所述方法包括：获得表达17β-HSD3的重组宿主细胞; 得到包含17β-HSD3，雄烯二酮和反应试剂的反应混合物; 通过使用与睾酮特异性抗体缀合的SPA珠的闪烁邻近测定（SPA）测量反应混合物中的睾酮的量，其中当在测试试剂存在下睾酮的量低于不存在测试时，睾酮的量较低 试剂被鉴定为17β-HSD3的抑制剂。

    Polynucleotides encoding human histone deacetylase HDAC9c
    10.
    发明授权
    Polynucleotides encoding human histone deacetylase HDAC9c 有权
    编码人组蛋白脱乙酰酶HDAC9c的多核苷酸

    公开(公告)号：US07199227B2

    公开(公告)日：2007-04-03

    申请号：US10172094

    申请日：2002-06-14

    申请人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Ricardo M. Attar ,  Marco Gottardis ,  Liana M. Lee ,  John N. Feder

    发明人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Ricardo M. Attar ,  Marco Gottardis ,  Liana M. Lee ,  John N. Feder

    IPC分类号： C07H21/04

    CPC分类号： C12N9/16

    摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

    摘要翻译： 本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。 本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。 本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。 还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。 本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。 这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。