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    Tool
    1.
    发明申请
    Tool 审中-公开
    工具

    公开(公告)号：US20050153640A1

    公开(公告)日：2005-07-14

    申请号：US11017921

    申请日：2004-12-22

    申请人： Markus Stein ,  Nicolas Huth

    发明人： Markus Stein ,  Nicolas Huth

    IPC分类号： B24B45/00 ,  B24D9/00 ,  B24D9/10

    CPC分类号： B24D9/006 ,  B24B45/006

    摘要： In a tool comprising a supporting part and a disk-shaped working part for machining operation, the supporting part comprises a supporting face for the working part and a permanent magnet within the supporting face. The working part comprises a coupling member of ferromagnetic material which is movable into magnetically clinging connection with the permanent magnet upon application of a counterpart supporting face to the supporting face.

    摘要翻译： 在包括用于加工操作的支撑部件和盘形加工部件的工具中，支撑部件包括用于工作部件的支撑面和支撑面内的永磁体。 工作部件包括铁磁材料的连接构件，当将对应的支撑面施加到支撑面上时，该耦合构件可移动成与永磁体的磁力附着连接。

    TOOL WITH A CARRIER PART AND A DISC-SHAPED WORKING PART
    2.
    发明申请
    TOOL WITH A CARRIER PART AND A DISC-SHAPED WORKING PART 审中-公开
    具有运输部件和盘形工作部件的工具

    公开(公告)号：US20070010184A1

    公开(公告)日：2007-01-11

    申请号：US11428753

    申请日：2006-07-05

    申请人： Markus Stein ,  Nicolas Huth

    发明人： Markus Stein ,  Nicolas Huth

    IPC分类号： B23F21/03

    CPC分类号： B24D13/20 ,  B24B45/003 ,  B24D9/085

    摘要： A tool exhibits a carrier part and a disc-shaped working part for chip-forming machining. The two parts are detachably connected with each other by means of a coupling part and a counter-coupling part that inter-lock. They exhibit convex and concave wall sections adapted to each other. Moreover, there is created a latch-in connection by an inside hexagon aperture and an outside hexagon.

    摘要翻译： 刀具具有用于芯片成形加工的托架部件和盘形加工部件。 这两个部件通过联锁部分和相互锁定的反耦合部分可拆卸地彼此连接。 它们表现出适合于彼此的凸和凹壁部分。 此外，通过内六角孔和外六边形形成闩锁连接。

    Sensor Head for Film Measurements
    3.
    发明申请
    Sensor Head for Film Measurements 有权
    电影测量用传感器头

    公开(公告)号：US20110107818A1

    公开(公告)日：2011-05-12

    申请号：US12938831

    申请日：2010-11-03

    申请人： Stefan Konermann ,  Markus Stein

    发明人： Stefan Konermann ,  Markus Stein

    IPC分类号： G01B13/06

    CPC分类号： G01B7/087 ,  B29C47/0021 ,  B29C47/92 ,  B29C2947/92152 ,  G01B7/08

    摘要： A sensor head for measurement of a film, includes a guide surface (14) for the film, at least one sensor element (28, 30) integrated in the guide surface for measuring a property of the film, and a generator for generating an air cushion between the guide surface (14) and the film, the generator including a system for supplying a pressure medium, and a guide member (12) that is made of a porous material and forms at least a part of the guide surface (14) and is adapted to distributedly discharge the pressure medium into the air cushion, the guide member (12) having a channel system (16, 18) that divides the guide surface (14) into a plurality of fields (20, 22) that, if not disconnected, are connected only by narrow lands, the channel system being configured for draining the pressure medium from the air cushion.

    摘要翻译： 一种用于测量薄膜的传感器头，包括用于薄膜的导向表面（14），集成在导向表面中的用于测量薄膜性质的至少一个传感器元件（28,30）和用于产生空气的发生器 引导表面（14）和薄膜之间的缓冲垫，发生器包括用于供应压力介质的系统和由多孔材料制成并形成导向表面（14）的至少一部分的引导构件（12） 并且适于将所述压力介质分散地排放到所述气垫中，所述引导构件（12）具有通道系统（16,18），所述通道系统将所述引导表面（14）分成多个场（20,22），如果 没有断开连接，仅由狭窄的连接区连接，该通道系统被配置为从气垫排出压力介质。

    Apparatus and method for capacitive measurement of materials
    5.
    发明申请
    Apparatus and method for capacitive measurement of materials 失效
    材料电容测量的装置和方法

    公开(公告)号：US20060152231A1

    公开(公告)日：2006-07-13

    申请号：US11328031

    申请日：2006-01-09

    申请人： Stefan Konermann ,  Markus Stein

    发明人： Stefan Konermann ,  Markus Stein

    IPC分类号： G01R27/26 ,  G01N21/00

    CPC分类号： G01B7/087 ,  G01B7/06 ,  G01B7/08 ,  G01B2210/50

    摘要： Method for measuring thicknesses of a film, a foil or a material layer with a measuring head which is spaced away from the film and with which a capacitive thickness measurement is performed, in which an optical distance measurement is performed with a distance measuring device and a distance determined by the optical distance measurement is used in determining the film thickness in the capacitive thickness measurement.

    摘要翻译： 用于测量膜，箔或材料层的厚度的方法，其中测量头与膜间隔开并进行电容厚度测量，其中使用距离测量装置和 通过光学距离测量确定的距离用于确定电容厚度测量中的膜厚度。

    Method for contactless capacitive thickness measurements
    6.
    发明授权
    Method for contactless capacitive thickness measurements 有权
    非接触电容厚度测量方法

    公开(公告)号：US08315833B2

    公开(公告)日：2012-11-20

    申请号：US12664975

    申请日：2008-08-19

    申请人： Stefan Konermann ,  Markus Stein

    发明人： Stefan Konermann ,  Markus Stein

    IPC分类号： G01B7/02 ,  G01B11/02 ,  G01B13/02

    CPC分类号： G01B7/087

    摘要： A method for contactless capacitive thickness measurement of a flat material (10) that is placed in the fringe field (32) of a capacitor (C1,C2), with simultaneous measurement of the width L of an air gap (16) between the flat material and the capacitor plates, in which the capacities gL, kL of two capacitors (C1, C2) are measured whose fringe fields (32) decay at different rates towards the flat material (10), and in that both, the thickness D of the flat material (10) and the width L of the air gap (16) are determined on the basis of the condition that, for each capacitor (C1, C2), the measured capacity gL, kL is equal to the integral of the capacity gradient g′, k′ over the thickness of the flat material (10).

    摘要翻译： 一种放置在电容器（C1，C2）的边缘区域（32）中的扁平材料（10）的非接触电容厚度测量方法，同时测量平坦的空气间隙（16）的宽度L 材料和电容器板，其中测量两个电容器（C1，C2）的电容gL，kL，其边缘场（32）以不同的速率朝向扁平材料（10）衰减，并且在两者中，厚度D 基于对于每个电容器（C1，C2），测量容量gL，kL等于容量的积分的条件来确定气隙（16）的扁平材料（10）和气隙（16）的宽度L 梯度g'，k'超过扁平材料（10）的厚度。

    Method for detecting a host receptor for pathogenic bacteria
    7.
    发明授权
    Method for detecting a host receptor for pathogenic bacteria 失效
    检测病原菌宿主受体的方法

    公开(公告)号：US07531315B2

    公开(公告)日：2009-05-12

    申请号：US11558277

    申请日：2006-11-09

    申请人： Brett B. Finlay ,  Brendan Kenny ,  Rebekah DeVinney ,  Markus Stein

    发明人： Brett B. Finlay ,  Brendan Kenny ,  Rebekah DeVinney ,  Markus Stein

    IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/00

    CPC分类号： C07K14/245 ,  A61K38/00 ,  A61K39/0258 ,  C07K16/1232 ,  C07K2319/00 ,  Y02A50/474 ,  Y10S435/975 ,  Y10S530/825

    摘要： A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.

    摘要翻译： 称为Tir的多肽（用于易位的intimin受体，其通过附着和消除病原体如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌）分泌，这些细菌病原体将它们自己的受体插入哺乳动物细胞表面，其中 细菌病原体然后粘附以触发另外的宿主信号事件和肌动蛋白成核。由病原性大肠杆菌引起的疾病的诊断可以通过使用结合Tir的抗体来检测蛋白质或使用核酸探针来检测 提供编码Tir多肽的核酸，分离编码Tir多肽，Tir肽，重组Tir重组方法，与Tir结合的抗体的核酸序列，以及用于检测产生Tir的大肠杆菌的试剂盒。 还提供用Tir免疫宿主以诱导针对Tir或第二感兴趣的多肽的保护性免疫应答。用于筛选组合物的方法 进一步提供干扰细菌病原体与其受体的结合的蛋白质。

    Host Receptor for Pathogenic Bacteria
    8.
    发明申请
    Host Receptor for Pathogenic Bacteria 失效
    宿主受体为致病细菌

    公开(公告)号：US20070213509A1

    公开(公告)日：2007-09-13

    申请号：US11558268

    申请日：2006-11-09

    申请人： Brett Finlay ,  Brendan Kenny ,  Rebekah DeVinney ,  Markus Stein

    发明人： Brett Finlay ,  Brendan Kenny ,  Rebekah DeVinney ,  Markus Stein

    IPC分类号： C07K16/28

    CPC分类号： C07K14/245 ,  A61K38/00 ,  A61K39/0258 ,  C07K16/1232 ,  C07K2319/00 ,  Y02A50/474 ,  Y10S435/975 ,  Y10S530/825

    摘要： A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interst is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.

    摘要翻译： 称为Tir的多肽（用于易位的intimin受体，其通过附着和消除病原体如肠致病性（EPEC）和肠出血性（EHEC）大肠杆菌）分泌，这些细菌病原体将它们自己的受体插入哺乳动物细胞表面，其中 细菌病原体然后粘附以触发另外的宿主信号事件和肌动蛋白成核。由致病性大肠杆菌引起的疾病的诊断可以通过使用结合Tir的抗体来检测蛋白质或使用核酸探针来检测 提供编码Tir多肽的核酸，分离编码Tir多肽，Tir肽，重组Tir重组方法，与Tir结合的抗体的核酸序列，以及用于检测产生Tir的大肠杆菌的试剂盒。 还提供用Tir免疫宿主以诱导针对Tir或第二间期多肽的保护性免疫应答。用于筛选组合物的方法 进一步提供干扰细菌病原体与其受体的结合的物质。

    Apparatus for measuring film bubbles
    10.
    发明授权
    Apparatus for measuring film bubbles 有权
    用于测量薄膜气泡的装置

    公开(公告)号：US08561313B2

    公开(公告)日：2013-10-22

    申请号：US13095177

    申请日：2011-04-27

    申请人： Frank Müller ,  Markus Stein ,  Stefan Konermann

    发明人： Frank Müller ,  Markus Stein ,  Stefan Konermann

    IPC分类号： G01D21/00

    CPC分类号： G01B5/0004 ,  B29C47/0009 ,  B29C47/92 ,  B29C2791/007 ,  B29C2947/92123 ,  B29C2947/92428 ,  B29K2995/0053 ,  B29L2023/001 ,  G01B21/047

    摘要： An apparatus for measuring film bubbles (10), includes a guide track (22) that extends in a circumferential direction of the film bubble with a constant spacing relative to the latter, the guide track guiding a carriage (20) which carries a measuring head (12) facing the peripheral surface of the film bubble (10), the measuring head (12) is connected to a free end of a cantilever (18) via an articulated joint (16), the cantilever having another end pivotally connected to the carriage (20), and a compensating drive mechanism (30) for correcting a change in the orientation of the measuring head (12) resulting from a pivotal movement of the cantilever (18) is associated with the articulated joint (16).

    摘要翻译： 一种用于测量薄膜气泡（10）的装置，包括一个导向轨道（22），导向轨道（22）以相对于薄膜气泡的圆周方向以一定间隔延伸，导轨引导托架（20），该托架承载测量头 （12）面对薄膜气泡（10）的外周表面，测量头（12）通过铰接接头（16）连接到悬臂（18）的自由端，悬臂具有另一端枢转地连接到 以及用于校正由悬臂（18）的枢转运动引起的测量头（12）的方位变化的补偿驱动机构（30）与铰接接头（16）相关联。