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    Carrier Conjugates Of Tnf-Peptides
    3.
    发明申请
    Carrier Conjugates Of Tnf-Peptides 审中-公开
    Tnf肽的载体结合体

    公开(公告)号：US20080019991A1

    公开(公告)日：2008-01-24

    申请号：US11628243

    申请日：2005-06-02

    申请人： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

    发明人： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

    IPC分类号： A61K39/00 ,  A61K45/00 ,  C12N7/01

    CPC分类号： C12N7/00 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  C07K14/525 ,  C07K2319/00 ,  C12N2710/00023 ,  C12N2730/10123 ,  C12N2795/00023

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒（VLP）。 本发明还提供了用于生产修饰的VLP的方法。 本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Vlp-Antigen Conjugates and Their Uses as Vaccines
    6.
    发明申请
    Vlp-Antigen Conjugates and Their Uses as Vaccines 失效
    Vlp抗原结合物及其用途作为疫苗

    公开(公告)号：US20080095738A1

    公开(公告)日：2008-04-24

    申请号：US11664716

    申请日：2005-10-05

    申请人： Martin Bachmann ,  Patrik Maurer ,  Edwin Meijerink ,  Katrin Schwarz ,  Karl Proba

    发明人： Martin Bachmann ,  Patrik Maurer ,  Edwin Meijerink ,  Katrin Schwarz ,  Karl Proba

    IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P29/00 ,  A61P37/00 ,  A61K39/385

    CPC分类号： A61K39/0013 ,  A61K39/0005 ,  A61K39/0006 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55583 ,  A61K2039/57 ,  A61K2039/6075 ,  C12N2740/16211 ,  C12N2795/18123

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含RNA噬菌体的病毒样颗粒（VLP）和至少一种抗原的组合物，其中VLP在宿主中重组产生，并且其中由VLP包含的具有二级结构的宿主RNA的量为 最多20％的具有二级结构的宿主RNA的量最初由VLP组成; 并且其中所述VLP和所述至少一种抗原彼此连接。 本发明还提供了制备本发明组合物的方法。 本发明的组合物可用于生产用于治疗疾病，病症和病症的疫苗。 此外，本发明的组合物特别可用于在降低或消除不想要的T细胞应答的同时在指定的上下文中有效地诱导针对抗原的强抗体应答。

    Hapten-carrier conjugates and uses thereof
    10.
    发明申请
    Hapten-carrier conjugates and uses thereof 失效
    黑色素 - 载体缀合物及其用途

    公开(公告)号：US20050281845A1

    公开(公告)日：2005-12-22

    申请号：US11125402

    申请日：2005-05-10

    申请人： Martin Bachmann ,  Patrik Maurer

    发明人： Martin Bachmann ,  Patrik Maurer

    IPC分类号： A61K39/385 ,  A61K47/48 ,  C07K14/005 ,  C07K14/02 ,  C07K14/08 ,  C07K14/195 ,  C12Q1/68 ,  A01N37/12 ,  A01N37/44 ,  A61K31/195 ,  A61K39/12

    CPC分类号： C07K17/02 ,  A61K39/0013 ,  A61K39/385 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/6075 ,  C07K14/005 ,  C12N2730/10122 ,  C12N2795/18123

    摘要： The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

    摘要翻译： 本发明提供了包含有序和重复排列的半抗原与载体的缀合物的组合物，以及制备这种组合物的方法。 本发明的缀合物和组合物可以包含各种半抗原，包括激素，毒素和药物，特别是成瘾药物如尼古丁。 本发明的组合物和缀合物可用于诱导针对半抗原的免疫应答，其可用于各种治疗，预防和诊断方案中。 在某些实施方案中，使用本发明的缀合物，组合物和方法产生的免疫应答可用于预防或治疗滥用药物的成瘾以及与药物成瘾相关的所得疾病。