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公开(公告)号：US20060251677A1
公开(公告)日：2006-11-09
申请号：US10550518
申请日：2004-03-25
申请人： Martin Bachmann , Andreas Cornelius , Vania Manolova , Patrik Maurer , Edwin Meijerink , Karl Proba , Katrin Schwarz
发明人： Martin Bachmann , Andreas Cornelius , Vania Manolova , Patrik Maurer , Edwin Meijerink , Karl Proba , Katrin Schwarz
CPC分类号： C12N15/117 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/5258 , A61K2039/55561 , A61K2039/6075 , C07K14/005 , C07K14/4748 , C07K2319/00 , C12N2310/18 , C12N2710/20022 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , C12N2760/10022 , C12N2760/10034 , C12N2795/18122 , C12N2795/18123 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
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2.发明授权Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use 失效将免疫刺激性寡核苷酸包装成病毒样颗粒：制备和使用方法公开(公告)号：US07517520B2
公开(公告)日：2009-04-14
申请号：US10550518
申请日：2004-03-25
申请人： Vania Manolova , Martin F. Bachmann , Andreas Cornelius , Patrik Maurer , Edwin Meijerink , Karl G. Proba , Katrin Schwarz
发明人： Vania Manolova , Martin F. Bachmann , Andreas Cornelius , Patrik Maurer , Edwin Meijerink , Karl G. Proba , Katrin Schwarz
CPC分类号： C12N15/117 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/5258 , A61K2039/55561 , A61K2039/6075 , C07K14/005 , C07K14/4748 , C07K2319/00 , C12N2310/18 , C12N2710/20022 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , C12N2760/10022 , C12N2760/10034 , C12N2795/18122 , C12N2795/18123 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译： 本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。 这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。 与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。 此外，针对VLP和抗原的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。
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3.发明申请Packaging of Immunostimulatory Substances Into Virus-Like Particles: Method of Preparation and Use 审中-公开将免疫刺激物质包装到病毒样颗粒中：制备和使用方法公开(公告)号：US20100098722A1
公开(公告)日：2010-04-22
申请号：US12410085
申请日：2009-03-24
申请人： Martin F. BACHMANN , Andreas Cornelius , Vania Manolova , Patrik Maurer , Edwin Meijerink , Karl G. Proba , Katrin Schwarz
发明人： Martin F. BACHMANN , Andreas Cornelius , Vania Manolova , Patrik Maurer , Edwin Meijerink , Karl G. Proba , Katrin Schwarz
CPC分类号： C12N15/117 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/5258 , A61K2039/55561 , A61K2039/6075 , C07K14/005 , C07K14/4748 , C07K2319/00 , C12N2310/18 , C12N2710/20022 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , C12N2760/10022 , C12N2760/10034 , C12N2795/18122 , C12N2795/18123 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译： 本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。 这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。 与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。 此外，针对VLP和抗原的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。
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公开(公告)号：US20080095738A1
公开(公告)日：2008-04-24
申请号：US11664716
申请日：2005-10-05
申请人： Martin Bachmann , Patrik Maurer , Edwin Meijerink , Katrin Schwarz , Karl Proba
发明人： Martin Bachmann , Patrik Maurer , Edwin Meijerink , Katrin Schwarz , Karl Proba
IPC分类号： A61K39/39 , A61K39/00 , A61P29/00 , A61P37/00 , A61K39/385
CPC分类号： A61K39/0013 , A61K39/0005 , A61K39/0006 , A61K39/0011 , A61K39/39 , A61K2039/5258 , A61K2039/55511 , A61K2039/55516 , A61K2039/55583 , A61K2039/57 , A61K2039/6075 , C12N2740/16211 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含RNA噬菌体的病毒样颗粒（VLP）和至少一种抗原的组合物，其中VLP在宿主中重组产生，并且其中由VLP包含的具有二级结构的宿主RNA的量为 最多20％的具有二级结构的宿主RNA的量最初由VLP组成; 并且其中所述VLP和所述至少一种抗原彼此连接。 本发明还提供了制备本发明组合物的方法。 本发明的组合物可用于生产用于治疗疾病，病症和病症的疫苗。 此外，本发明的组合物特别可用于在降低或消除不想要的T细胞应答的同时在指定的上下文中有效地诱导针对抗原的强抗体应答。
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5.发明申请Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 审中-公开免疫刺激核酸包装颗粒治疗超敏反应公开(公告)号：US20070184068A1
公开(公告)日：2007-08-09
申请号：US11638664
申请日：2006-12-14
申请人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang Renner , Martin Bachmann , Indulis Cielens , Conrad Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译： 本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。 本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。
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6.发明授权Packaging of immunostimulatory substances into virus-like particles: method of preparation and use 有权将免疫刺激物质包装成病毒样颗粒：制备和使用方法公开(公告)号：US08691209B2
公开(公告)日：2014-04-08
申请号：US13294006
申请日：2011-11-10
申请人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
CPC分类号： A61K39/12 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/39 , A61K2039/52 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2730/10122 , C12N2730/10123 , C12N2795/00034 , C12N2795/18122 , Y02A50/412 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译： 本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。 这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。 与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。 此外，针对VLP和抗原的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。
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公开(公告)号：US07959928B2
公开(公告)日：2011-06-14
申请号：US11664716
申请日：2005-10-05
CPC分类号： A61K39/0013 , A61K39/0005 , A61K39/0006 , A61K39/0011 , A61K39/39 , A61K2039/5258 , A61K2039/55511 , A61K2039/55516 , A61K2039/55583 , A61K2039/57 , A61K2039/6075 , C12N2740/16211 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含RNA噬菌体的病毒样颗粒（VLP）和至少一种抗原的组合物，其中VLP在宿主中重组产生，并且其中由VLP包含的具有二级结构的宿主RNA的量为 最多20％的具有二级结构的宿主RNA的量最初由VLP组成; 并且其中所述VLP和所述至少一种抗原彼此连接。 本发明还提供了制备本发明组合物的方法。 本发明的组合物可用于生产用于治疗疾病，病症和病症的疫苗。 此外，本发明的组合物特别可用于在降低或消除不想要的T细胞应答的同时在指定的上下文中有效地诱导针对抗原的强抗体应答。
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8.发明授权公开(公告)号：US08574564B2
公开(公告)日：2013-11-05
申请号：US12576086
申请日：2009-10-08
申请人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译： 本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。 本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。
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公开(公告)号：US20080019991A1
公开(公告)日：2008-01-24
申请号：US11628243
申请日：2005-06-02
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
CPC分类号： C12N7/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/525 , C07K2319/00 , C12N2710/00023 , C12N2730/10123 , C12N2795/00023
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒（VLP）。 本发明还提供了用于生产修饰的VLP的方法。 本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号：US07785873B2
公开(公告)日：2010-08-31
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。 更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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