公开(公告)号：US20050020588A1

公开(公告)日：2005-01-27

申请号：US10929133

申请日：2004-08-27

申请人： Martin Quibell ,  Steven Taylor ,  Urszula Grabowska ,  Magnus Nilsson ,  Veronique Morisson

发明人： Martin Quibell ,  Steven Taylor ,  Urszula Grabowska ,  Magnus Nilsson ,  Veronique Morisson

IPC分类号： C07D307/22 ,  C07D307/32 ,  C07D307/68 ,  C07D307/85 ,  C07D309/14 ,  C07D309/30 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  A61K31/541 ,  A61K31/496 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02 ,  C07

CPC分类号： C07D307/32 ,  C07D307/22 ,  C07D307/68 ,  C07D307/85 ,  C07D309/14 ,  C07D309/30 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

摘要： Cathepsin S is a highly active cysteine protease belonging to the papain superfamily. It is found mainly in lymph nodes, spleen, and macrophages and this limited occurrence suggests the potential involvement of this enzyme in the pathogenesis of degenerative disease. The invention relates to novel protease inhibitors, particularly inhibitors of the cysteine proteases of the papain superfamily and more particularly to Cathepsin S. The inhibitors are Furanone derivatives of Formula (II) which have a characteristic non-hydrogen substituent R5. They are selective over other members of the family and in particular show selectivity over other members of the Cathepsin family such as L and K.

摘要翻译： 组织蛋白酶S是属于木瓜蛋白酶超家族的高活性半胱氨酸蛋白酶。 主要发现在淋巴结，脾脏和巨噬细胞中，这种有限的发生表明该酶潜在地参与退行性疾病的发病机制。 本发明涉及新型蛋白酶抑制剂，特别是木瓜蛋白酶超家族的半胱氨酸蛋白酶的抑制剂，更具体地涉及组织蛋白酶S.抑制剂是具有特征非氢取代基R5的式（II）的呋喃酮衍生物。 它们对家族的其他成员具有选择性，并且特别地显示出组织蛋白酶家族的其它成员如L和K的选择性。

公开(公告)号：US20050070598A1

公开(公告)日：2005-03-31

申请号：US10678947

申请日：2003-10-03

申请人： Martin Quibell ,  Steven Taylor ,  Urszula Grabowska ,  Magnus Nilsson ,  Veronique Morrison

发明人： Martin Quibell ,  Steven Taylor ,  Urszula Grabowska ,  Magnus Nilsson ,  Veronique Morrison

IPC分类号： C07D307/22 ,  C07D307/32 ,  C07D307/68 ,  C07D307/85 ,  C07D309/14 ,  C07D309/30 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  A61K31/541 ,  A61K31/366 ,  A61K31/496 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02 ,  C07D45/02

CPC分类号： C07D405/12 ,  C07D307/22 ,  C07D307/32 ,  C07D307/68 ,  C07D307/85 ,  C07D309/14 ,  C07D309/30 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

摘要： of the formula (IV): where: R1=R′C(O), R′SO2, R′=a bicyclic, saturated or unsaturated, 8-12 membered ring system containing 0-4 hetero atoms selected from S, O and N, which is optionally substituted with up to four substituents independently selected from groups a), b) and c) below; or R′=a monocyclic, saturated or unsaturated, 5-7 membered ring containing 0-3 hetero atoms selected from S, O and N, which monocyclic ring bears at least one substituent selected from group a) and/or c) and which may optionally bear one or two further substituents selected from group b); R4=H, C1-7-alkyl, Ar—C1-7-alkyl, Ar, C3-7-cycloalkyl; C2-7alkenyl; R3=C1-7-alkyl, C2-C7 alkenyl, C2-C7 alkenyl, C3-7-cycloalkyl, Ar—C1-7-alkyl, Ar; R5=C1-7-alkyl, halogen, Ar—C1-7-alkyl, CO-3-alkyl-CONR3R4 or a bulky amine R6 is H, C1-7-alkyl, Ar—C1-7-alkyl, C1-3-alkyl-SO2-Rix, C1-3-alkyl-C(O)—NHRix or CH2XAr q is 0 or 1 have utility as inhibitors of cysteine proteases such as cathepsin K and falcipain.

摘要翻译： 式（Ⅳ）：其中：R1 = R'C（O），R'SO2，R'=含有0-4个杂原子的双环饱和或不饱和的8-12元环系，其选自S，O和 N，其任选被至多四个独立地选自以下的基团a），b）和c）中的取代基取代; 或R'=含有0-3个选自S，O和N的杂原子的单环，饱和或不饱和的5-7元环，该单环具有至少一个选自a）和/或c）的取代基，并且其中 可以任选地带有一个或两个其它选自组b）的取代基; R 4 = H，C 1-7 - 烷基，Ar-C 1-7 - 烷基，Ar，C 3-7 - 环烷基; C2-7烯基; R 3 = C 1-7 - 烷基，C 2 -C 7烯基，C 2 -C 7链烯基，C 3-7 - 环烷基，Ar-C 1-7 - 烷基，Ar; R 5 = C 1-7 - 烷基，卤素，Ar-C 1-7 - 烷基，CO-3-烷基-CONR 3 R 4或大体积的胺R 6是H，C 1-7 - 烷基，Ar-C 1-7 - 烷基，C 1-3 - 烷基-SO 2 -R 5，C 1-3 - 烷基-C（O）-NHR x或CH 2 XAr q为0或1可用作半胱氨酸蛋白酶如组织蛋白酶K和恶性蛋白酶的抑制剂。

公开(公告)号：US08071607B2

公开(公告)日：2011-12-06

申请号：US11722484

申请日：2005-12-22

申请人： Thomas Stephen Coulter ,  Steven Taylor ,  Stephen Murfin ,  Valery Thammalaksa ,  Babette Aicher ,  Stefan Jaekel ,  Tanja Reuter

发明人： Thomas Stephen Coulter ,  Steven Taylor ,  Stephen Murfin ,  Valery Thammalaksa ,  Babette Aicher ,  Stefan Jaekel ,  Tanja Reuter

IPC分类号： A01N43/90 ,  A61K31/519

CPC分类号： A61K31/519

摘要： The present invention relates to the use of pyrazolopyrimidine compounds for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

摘要翻译： 本发明涉及吡唑并嘧啶化合物用于生产药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b）的激酶活性和/或 其变体。

公开(公告)号：US20100056548A1

公开(公告)日：2010-03-04

申请号：US12296427

申请日：2007-04-10

申请人： Babette Aicher ,  Thomas Stephen Coulter ,  Stefan Jaekel ,  Arndt-René Kelter ,  Stephen Murfin ,  Tanja Reuter ,  Steven Taylor

发明人： Babette Aicher ,  Thomas Stephen Coulter ,  Stefan Jaekel ,  Arndt-René Kelter ,  Stephen Murfin ,  Tanja Reuter ,  Steven Taylor

IPC分类号： A61K31/519 ,  C07D495/04 ,  A61P3/00 ,  A61P35/00 ,  A61P3/10 ,  A61P3/04 ,  A61P9/12 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D495/04

摘要： The present invention relates to novel pharmaceutical compositions comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

摘要翻译： 本发明涉及包含噻吩并嘧啶化合物的新型药物组合物。 此外，本发明涉及本发明的噻吩并嘧啶化合物用于生产药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a）激酶活性的疾病的用途 或Mnk2b）和/或其变体。

公开(公告)号：US20070000329A1

公开(公告)日：2007-01-04

申请号：US11172129

申请日：2005-06-29

申请人： Steven Taylor ,  Nancy Kraft

发明人： Steven Taylor ,  Nancy Kraft

IPC分类号： G01N29/04

CPC分类号： G01N29/2456 ,  B06B1/0651 ,  G01N29/221 ,  G01N29/348

摘要： An ultrasonic transducer having an effective center frequency of about 42 MHz; a bandwidth of greater than 85% at 6 dB; a spherical focus of at least 0.5 inches in water; an F4 lens; a resolution sufficient to be able to detect and separate a 0.005 inch flat-bottomed hole at 0.005 inches below surface; and a beam size of approximately 0.006-0.008 inches measured off a 1½ mm ball in water at the transducer's focal point.

摘要翻译： 具有约42MHz有效中心频率的超声换能器; 6 dB时带宽大于85％; 水中至少0.5英寸的球形焦点; F4镜头; 足以能够检测和分离0.005英寸的低于表面0.005英寸的平底孔的分辨率; 并且在换能器焦点处的水中的1/2英寸球测量的大约0.006-0.008英寸的光束尺寸。

公开(公告)号：US20060276515A1

公开(公告)日：2006-12-07

申请号：US11381015

申请日：2006-05-01

申请人： Charles Cywin ,  Stephane De Lombaert ,  Anne Eldrup ,  Richard Ingraham ,  Fariba Soleymanzadeh ,  Steven Taylor ,  Mario Cardozo

发明人： Charles Cywin ,  Stephane De Lombaert ,  Anne Eldrup ,  Richard Ingraham ,  Fariba Soleymanzadeh ,  Steven Taylor ,  Mario Cardozo

IPC分类号： A61K31/4439 ,  A61K31/4415 ,  A61K31/277 ,  A61K31/165

CPC分类号： C07D213/82 ,  C07D213/56 ,  C07D213/81 ,  C07D215/50 ,  C07D217/26 ,  C07D231/12 ,  C07D231/14 ,  C07D233/90 ,  C07D241/24 ,  C07D295/155 ,  C07D401/04

摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

公开(公告)号：US20050288973A1

公开(公告)日：2005-12-29

申请号：US10875524

申请日：2004-06-24

申请人： Steven Taylor ,  Kevin Krone ,  Victor Lucas ,  Jason Chancellor ,  Michael Neely ,  Mark Gerber ,  Bobby Cude

发明人： Steven Taylor ,  Kevin Krone ,  Victor Lucas ,  Jason Chancellor ,  Michael Neely ,  Mark Gerber ,  Bobby Cude

IPC分类号： G06Q10/00 ,  G06Q50/00

CPC分类号： G06Q50/14 ,  G06Q10/02

摘要： A system and method for changing a travel itinerary include receiving a request to make a change to a first travel itinerary that includes at least one segment, displaying an identification of one or more alternative segments, receiving a user selection of one of the alternative segments, modifying the first itinerary to include a reservation for the selected alternative segment, and releasing the segment of the first itinerary to be replaced by the selected alternative segments. The system and method may also include calculating a fare difference between the one or more alternative segments and the original segment to be replaced.

摘要翻译： 用于改变旅行行程的系统和方法包括接收对包括至少一个段的第一旅行行程进行改变的请求，显示一个或多个替代段的标识，接收替代段之一的用户选择， 修改第一行程以包括所选替代段的预留，以及释放要由所选替代段替换的第一行程的段。 该系统和方法还可以包括计算一个或多个替代段与要替换的原始段之间的车费差值。

公开(公告)号：US6092613A

公开(公告)日：2000-07-25

申请号：US207909

申请日：1998-12-09

申请人： Douglas Caraway ,  John Hayward ,  Malcolm R. Taylor ,  Tom Scott Roberts ,  Steven Taylor ,  Graham R Watson

发明人： Douglas Caraway ,  John Hayward ,  Malcolm R. Taylor ,  Tom Scott Roberts ,  Steven Taylor ,  Graham R Watson

IPC分类号： E21B10/00 ,  E21B10/26 ,  E21B10/54 ,  E21B10/55 ,  E21B10/60 ,  E21B17/10

CPC分类号： E21B10/55 ,  E21B10/003 ,  E21B10/26 ,  E21B10/60 ,  E21B10/602 ,  E21B17/1092

摘要： A rotary drill bit for use in drilling holes in subsurface formations comprises a bit body having a leading face and a gauge region, a number of blades formed on the leading face of the bit and extending outwardly away from the axis of the bit so as to define between the blades a number of fluid channels leading towards the gauge region, a number of cutting elements mounted side-by-side along each blade, and a number of nozzles in the bit body for supplying drilling fluid to the fluid channels for cleaning and cooling the cutting elements. In each of the fluid channels, adjacent the gauge region, is an opening into an enclosed passage which passes internally through the bit body to an outlet which, in use, communicates with the annulus between the drill string and the wall of the borehole being drilled. The gauge region of the drill bit comprises a substantially continuous bearing surface which extends around the whole of the gauge region.

公开(公告)号：USD304219S

公开(公告)日：1989-10-24

申请号：US920800

申请日：1986-10-17

申请人： Steven Taylor

设计人： Steven Taylor

公开(公告)号：US20060263692A1

公开(公告)日：2006-11-23

申请号：US11495520

申请日：2006-07-31

申请人： Kurtis Kelley ,  Steven Taylor

发明人： Kurtis Kelley ,  Steven Taylor

IPC分类号： H01M4/66 ,  B05D5/12 ,  H01M4/68 ,  H01M4/56

CPC分类号： H01M4/366 ,  H01G11/34 ,  H01M4/20 ,  H01M4/73 ,  H01M10/06 ,  Y02E60/126 ,  Y02E60/13 ,  Y02P70/54

摘要： A method for forming a corrosion resistant electrode for a battery includes supplying an electrode for use in the battery and exposing the electrode to an environment including vaporized carbon. At least some of the carbon from the environment may be transferred to the electrode.