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公开(公告)号:US20060229280A1
公开(公告)日:2006-10-12
申请号:US11063476
申请日:2005-02-23
申请人: Martin Winn , Steven Boyd , Charles Hutchins , Hwan-Soo Jae , Andrew Tasker , Thomas von Geldern , Jeffrey Kester , Bryan Sorensen , Bruce Szczepankiewicz , Kenneth Henry , Gang Liu , Steven Wittenberger , Steven King
发明人: Martin Winn , Steven Boyd , Charles Hutchins , Hwan-Soo Jae , Andrew Tasker , Thomas von Geldern , Jeffrey Kester , Bryan Sorensen , Bruce Szczepankiewicz , Kenneth Henry , Gang Liu , Steven Wittenberger , Steven King
IPC分类号: A61K31/675 , A61K31/454 , C07D413/02 , C07D43/02
CPC分类号: C07D207/16 , C07D405/04 , C07D405/14 , C07D413/14
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号:US20060128962A1
公开(公告)日:2006-06-15
申请号:US11348155
申请日:2006-02-06
申请人: Michael Allen , Ramiya Premchandran , Sou-Jen Chang , Stephen Condon , John DeMattei , Steven King , Lawrence Kolaczkowski , Sukumar Manna , Paul Nichols , Hemant Patel , Subhash Patel , Daniel Plata , Eric Stoner , Jien-Heh Tien , Steven Wittenberger
发明人: Michael Allen , Ramiya Premchandran , Sou-Jen Chang , Stephen Condon , John DeMattei , Steven King , Lawrence Kolaczkowski , Sukumar Manna , Paul Nichols , Hemant Patel , Subhash Patel , Daniel Plata , Eric Stoner , Jien-Heh Tien , Steven Wittenberger
IPC分类号: C07D215/12 , C07C69/52 , C07D215/14
CPC分类号: C07D215/14 , C07C68/06 , C07C69/96
摘要: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
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3.(1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE 有权
标题翻译: (1S,5S)-3-(5,6-二氯-3-吡啶基)-3,6-二氮杂双环[3.2.0]庚烷公开(公告)号:US20080070891A1
公开(公告)日:2008-03-20
申请号:US11838745
申请日:2007-08-14
申请人: Michael Buckley , Jianguo Ji , Geoff Zhang , Rodger Henry , Weili Wang , Gregory Wayne , Wenke Li , Timothy Towne , Steven Wittenberger , Steven Hannick , Brian Kotecki , Bryan Macri , Timothy Robbins
发明人: Michael Buckley , Jianguo Ji , Geoff Zhang , Rodger Henry , Weili Wang , Gregory Wayne , Wenke Li , Timothy Towne , Steven Wittenberger , Steven Hannick , Brian Kotecki , Bryan Macri , Timothy Robbins
IPC分类号: A61K31/397 , A61P25/00 , C07D205/00
CPC分类号: C07D487/04 , A61K31/397
摘要: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
摘要翻译: 本发明公开了(1S,5S)-3-(5,6-二氯-3-吡啶基)-3,6-二氮杂双环[3.2.0]庚烷及其盐,其用于治疗与 烟碱乙酰胆碱受体。
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4.(1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE 有权
标题翻译: (1S,5S)-3-(5,6-二氯-3-吡啶基)-3,6-二氮杂双环[3.2.0]庚烷公开(公告)号:US20060035936A1
公开(公告)日:2006-02-16
申请号:US11176087
申请日:2005-07-07
申请人: Michael Buckley , Jianguo Ji , Geoff Zhang , Rodger Henry , Weili Wang , Gregory Wayne , Wenke Li , Timothy Towne , Steven Wittenberger , Steven Hannick , Brian Kotecki , Bryan Macri , Timothy Robbins
发明人: Michael Buckley , Jianguo Ji , Geoff Zhang , Rodger Henry , Weili Wang , Gregory Wayne , Wenke Li , Timothy Towne , Steven Wittenberger , Steven Hannick , Brian Kotecki , Bryan Macri , Timothy Robbins
IPC分类号: A61K31/4439
CPC分类号: C07D487/04 , A61K31/397
摘要: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
摘要翻译: 本发明公开了(1S,5S)-3-(5,6-二氯-3-吡啶基)-3,6-二氮杂双环[3.2.0]庚烷及其盐,其用于治疗与 烟碱乙酰胆碱受体。
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5.Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile 有权
标题翻译: (2S,5R)-5-乙炔基-1- {N-(4-甲基-1-(4-羧基 - 吡啶-2-基)哌啶-4-基)甘氨酰基}吡咯烷-2-甲腈公开(公告)号:US20080058528A1
公开(公告)日:2008-03-06
申请号:US11779936
申请日:2007-07-19
申请人: Todd McDermott , Seble Wagaw , Kenneth Engstrom , Jorge Gandarilla , Albert Kruger , Michael Rozema , Michael Fickes , Steven Wittenberger , Lakshmi Bhagavatula , Thomas Borchardt
发明人: Todd McDermott , Seble Wagaw , Kenneth Engstrom , Jorge Gandarilla , Albert Kruger , Michael Rozema , Michael Fickes , Steven Wittenberger , Lakshmi Bhagavatula , Thomas Borchardt
IPC分类号: C07D221/00 , C07D207/04 , C07F7/02 , C07D213/02
CPC分类号: C07D401/14 , C07D207/16 , C07D213/803 , C07D401/04 , C07F7/0803
摘要: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
摘要翻译: 制备(2S,5R)-5-乙炔基-1- {N-(4-甲基-1-(4-羧基 - 吡啶-2-基)哌啶-4-基)甘氨酰基}吡咯烷-2-甲腈 及其盐,以及该方法中使用的中间体。
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公开(公告)号:US20070232612A1
公开(公告)日:2007-10-04
申请号:US11674518
申请日:2007-02-13
申请人: Marlon Cowart , Chen Zhao , Minghua Sun , Lawrence Black , Guo Zheng , Robert Gregg , Geoff Zhang , Ahmand Sheikh , Xiaochun Lou , Rodger Henry , David Barnes , Lawrence Kolaczkowski , Anthony Haight , Sou-Jen Chang , Steven Wittenberger , Michael Fickes
发明人: Marlon Cowart , Chen Zhao , Minghua Sun , Lawrence Black , Guo Zheng , Robert Gregg , Geoff Zhang , Ahmand Sheikh , Xiaochun Lou , Rodger Henry , David Barnes , Lawrence Kolaczkowski , Anthony Haight , Sou-Jen Chang , Steven Wittenberger , Michael Fickes
IPC分类号: A61K31/506 , A61K31/501 , A61K31/496 , A61K31/4439 , A61K31/407 , C07D487/02 , A61K31/416
CPC分类号: C07D487/04
摘要: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译: 八氢 - 吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体,八氢吡咯并[3,4-b]吡咯化合物,使用这些化合物的方法,组合物 制备这些化合物的方法和方法。
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公开(公告)号:US20060025383A1
公开(公告)日:2006-02-02
申请号:US11050609
申请日:2005-02-03
申请人: Neil Wishart , Michael Friedman , Lee Arnold , Bryant Yang , Shannon Fix-Stenzel , Anna Ericsson , Michael Michaelides , Xiao-Dong Qian , James Holms , Douglas Steinman , Zhengping Tian , Steven Wittenberger
发明人: Neil Wishart , Michael Friedman , Lee Arnold , Bryant Yang , Shannon Fix-Stenzel , Anna Ericsson , Michael Michaelides , Xiao-Dong Qian , James Holms , Douglas Steinman , Zhengping Tian , Steven Wittenberger
IPC分类号: A61K31/5377 , A61K31/519 , A61K31/695 , C07D487/02
CPC分类号: C07D487/04
摘要: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译: 式(I)的化合物,其中取代基如本文所定义,其可用作激酶抑制剂。
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