摘要:
A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要:
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要:
Compounds are disclosed having the formula: ##STR1## wherein the substituents are defined herein. The compounds of the invention are angiotensin II receptor antagonists.
摘要:
Articles and methods of manufacture are provided for using laser energy in an automated bonding machine to effect laser welding of ribbons to electronic components, particularly conductive ribbons comprising titanium for microelectronic circuits. Bonding and connection of microelectronic circuits with discrete heating avoids heat damage to peripheral microelectronic components. Bonding of flexible materials and low-resistance materials are possible, and are less dependant on substrate and terminal stability in comparison to other bonding methods. The ribbon-connections can forgo the use of blocks, bond pads, and bond pad arrays for attaching ribbon to a printed wiring board. Profile height of the ribbon-connection is decreased and the density of ribbons and bonding sites can be increased compared to ribbon-connections employing bonding pads.
摘要:
Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要:
A method and system for assembling a component within a medical device that includes a test station to determine whether the component is in a predetermined working state, and an orientation sensor to sense an orientation vector of the component. A first sensor senses a position of the component within an aperture of the device and plots a weld path associated with the component. An installation head obtains the component, advances the component between the test station, the orientation sensor and the first sensor, and through the aperture, and a weld head generates a weld along a generated weld path.
摘要:
There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W—Ar (I) wherein, A is a group represented by the formula (A1) or (A2): (wherein, ring Aa is a 5- or 6-membered ring which may be further substituted; ring Ab is a 5- or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, —O—, —S—, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, —O—, —S—, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.
摘要:
Scaleable bacterial injection, aeration and filtration system to effectively control microbial community function of aquatic systems. The present invention is a substantially simplified system with respect to handling growth and dispersion of microorganisms in solution and is also adaptable to many different end-use applications, including treatment of ornamental fish and aquaculture, pond and streams and sewage treatment systems. Initial microorganism materials are provided in the form of aqueous suspensions, which are incorporated into a large volume of water in a vessel. Microorganisms are entrapped inside a carrier that serves as a physical enclosure for cell retention. It has a porous structure to facilitate the diffusion of substances, such as ammonia, nitrate, nutrients, fuels and organic carbon, into its internal void volume, where substrate reduction is accomplished by entrapped cells. Specific species of microbes are injected into a filtration matrix that is bathed in oxygenated effluent and a portion of which is dispensed into an aqueous environment. The apparatus can be electronic, air or fluid driven and injected with the desired microbial species, preferably multiple time per day. Multi-stage media can be placed into packed filter units of convenient sizes for wastewater regeneration as well as natural water pollution reduction. The reactor canisters containing entrapped cells are portable and can be assembled off-site and then delivered to the field for installation and immediate operation. Bio-solid reduction, odor reduction, unplugging of leaching fields, conversion and reduction of nitrogen species in natural waters such as lakes and ponds, etc. can be accomplished.
摘要:
Systems for treating water containing unwanted contaminants. More particularly, the present invention relates to waste water treatment systems including biological media used to aerobically or anaerobically treat solid and liquid waste in water for large and small-scale waste water systems in a way that minimizes the size of the system required to output high-quality, environmentally suitable water that is depleted of ammonia, nitrites, nitrates and other contaminants.