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1.发明申请Compositions derived from quinoline and quinoxaline, preparation and use thereof 审中-公开衍生自喹啉和喹喔啉的组合物，其制备和用途公开(公告)号：US20060183909A1
公开(公告)日：2006-08-17
申请号：US10499403
申请日：2002-07-19
申请人： Martine Schmitt , Evelyne Klotz , Jean-Paul Macher , Jean-Jacques Bourguignon , Mustapha Abarghaz , Patrick Wagner , Gael Ronsin
发明人： Martine Schmitt , Evelyne Klotz , Jean-Paul Macher , Jean-Jacques Bourguignon , Mustapha Abarghaz , Patrick Wagner , Gael Ronsin
IPC分类号： C07D215/36
CPC分类号： C07D401/04 , A61K31/50 , C07D215/14 , C07D215/44 , C07D215/48 , C07D241/44
摘要： The present invention concerns compounds derived from quinoline and quinoxaline, their preparation and their uses, particularly in the field of therapeutics and vaccines or for developing active compounds. The inventive compounds are of general formula (I), and their pharmaceutically acceptable salts.
摘要翻译： 本发明涉及衍生自喹啉和喹喔啉的化合物，其制备及其用途，特别是在治疗学和疫苗领域或用于开发活性化合物。 本发明化合物具有通式（I）及其药学上可接受的盐。
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2.发明申请公开(公告)号：US20060128695A1
公开(公告)日：2006-06-15
申请号：US10533157
申请日：2003-10-30
申请人： Jean-Jacques Bourguignon , Claire Lugnier , Mustapha Abarghaz , Yan Lagouge , Patrick Wagner , Cesare Mondadori , Jean-Paul Macher , Dominique Schultz , Pierre Raboisson
发明人： Jean-Jacques Bourguignon , Claire Lugnier , Mustapha Abarghaz , Yan Lagouge , Patrick Wagner , Cesare Mondadori , Jean-Paul Macher , Dominique Schultz , Pierre Raboisson
IPC分类号： A61K31/5513 , C07D403/02 , C07D243/12
CPC分类号： C07D401/04 , A61K31/5513 , A61K31/5517 , C07D243/20 , C07D243/22 , C07D243/24 , C07D405/04 , C07D417/10 , C07D487/04
摘要： The invention concerns the use of PDE2 inhibitors for treating disorders of the central and peripheral nervous system, a method for therapeutic treatment by administering to an animal said inhibitors. More specifically, the invention concerns novel benzodiazepinone derivatives and their uses in therapeutics more particularly for treating pathologies involving activity of a cyclic nucleotide phosphodiesterase type 2. The invention also concerns methods for preparing same and novel synthesis intermediates.
摘要翻译： 本发明涉及PDE2抑制剂用于治疗中枢和周围神经系统疾病的方法，一种通过向动物施用所述抑制剂进行治疗性治疗的方法。 更具体地，本发明涉及新的苯并二氮杂酮衍生物及其在治疗学中的用途，更具体地涉及治疗涉及2型环核苷酸磷酸二酯酶活性的病理学。本发明还涉及制备其和合成中间体的方法。
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3.发明授权Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof 失效苯并-1,4-二氮杂-2-酮衍生物作为磷酸二酯酶PDE2抑制剂，其制备和治疗用途公开(公告)号：US07410963B2
公开(公告)日：2008-08-12
申请号：US10582131
申请日：2004-12-23
申请人： Mustapha Abarghaz , Stefano Biondi , Jérôme Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
发明人： Mustapha Abarghaz , Stefano Biondi , Jérôme Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
IPC分类号： C07D243/24 , C07D413/04 , A61K31/5513
CPC分类号： C07D405/04 , C07D243/24
摘要： The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.
摘要翻译： 本发明涉及具有PDE2抑制活性的化合物，以及通过施用所述化合物，特别是用于治疗中枢或周围神经系统的各种疾病的治疗方法。 它还涉及包含所述化合物的药物组合物和制备所述化合物的方法。
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4.发明申请Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase pde2 inhibitors, preparation and therapeutic use thereof 失效苯并-1,4-二氮杂-2-酮衍生物作为磷酸二酯酶pde2抑制剂，其制备和治疗用途公开(公告)号：US20070123519A1
公开(公告)日：2007-05-31
申请号：US10582131
申请日：2004-12-23
申请人： Mustapha Abarghaz , Stefano Biondi , Jerome Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
发明人： Mustapha Abarghaz , Stefano Biondi , Jerome Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
IPC分类号： A61K31/5513 , C07D243/14
CPC分类号： C07D405/04 , C07D243/24
摘要： The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.
摘要翻译： 本发明涉及具有PDE2抑制活性的化合物，以及通过施用所述化合物，特别是用于治疗中枢或周围神经系统的各种疾病的治疗方法。 它还涉及包含所述化合物的药物组合物和制备所述化合物的方法。
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公开(公告)号：US08932868B2
公开(公告)日：2015-01-13
申请号：US13991223
申请日：2011-11-25
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value.
摘要翻译： 公开了用于检测和/或分配靶DNA和/或RNA双链体中的至少一个点突变的方法。 所述方法包括获得涂覆有靶DNA和/或RNA双链体的探针DNA和/或RNA的功能化表面，使所述功能化表面与流动池中具有中性pH的电解溶液接触并测量第一阻抗值 在所述电解液中，然后向能够实现靶DNA和/或RNA变性的电解液中加入化学物质。 该方法还包括在完成DNA和/或RNA靶变性后测量流动池内的第二阻抗值，然后获得代表该化学物质对电解溶液阻抗的影响的值。 然后通过基于第一和第二阻抗值之间的差异计算变性 - 时间常数并考虑到化学品的影响来确定靶DNA和/或RNA内的点突变的量和/或分配 通过第三阻抗值。
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公开(公告)号：US20140011198A1
公开(公告)日：2014-01-09
申请号：US13991227
申请日：2011-11-25
IPC分类号： C12Q1/68
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for characterising DNA and/or RNA duplexes. The biosensing device comprises a heating element using a power and being suitable for providing thermal denaturation of target DNA and/or RNA bioparticles, a sample holder adapted for receiving a biocompatible substrate having a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes can be attached, the sample holder further being adapted for exposing the biocompatible substrate at one side to the heating element, a first temperature sensing element for sensing a temperature at the side where the biocompatible substrate can be exposed to the heating element and a second temperature sensing element for sensing a temperature at the side opposite thereto with respect to the biocompatible substrate. The device also comprises a processing means programmed for calculating at least one heat transfer resistivity value based on temperature values obtained with the first temperature sensing element and the second temperature sensing element and the power for the heating element, for deriving a characteristic of the target DNA and/or RNA bioparticles from said heat transfer resistivity value.
摘要翻译： 公开了用于表征DNA和/或RNA双链体的方法。 生物传感装置包括使用功率并适合于提供靶DNA和/或RNA生物颗粒的热变性的加热元件，适于接收生物相容性底物的样品保持器，其具有涂覆有探针DNA和/或RNA的官能化表面， 可以连接靶DNA和/或RNA双链体，样品保持器还适于将一侧的生物相容性基底暴露于加热元件，第一温度感测元件，用于感测生物相容性基底可以暴露于的一侧的温度 加热元件和第二温度感测元件，用于感测与生物相容性基底相对的一侧的温度。 该装置还包括一个处理装置，其被编程用于基于用第一温度感测元件和第二温度感测元件获得的温度值和加热元件的功率来计算至少一个传热电阻率值，用于导出靶DNA的特征 和/或RNA生物颗粒从所述传热电阻率值。
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公开(公告)号：US09228970B2
公开(公告)日：2016-01-05
申请号：US13991227
申请日：2011-11-25
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C12Q1/68 , C07H21/02 , C07H21/04 , G01N15/06 , G01N27/00 , G01N25/00 , G01N31/22 , G01N27/327 , G01N27/02 , B01L3/00 , G05B15/02
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for characterizing DNA and/or RNA duplexes. The biosensing device comprises a heating element using a power and being suitable for providing thermal denaturation of target DNA and/or RNA bioparticles, a sample holder adapted for receiving a biocompatible substrate having a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes can be attached, the sample holder further being adapted for exposing the biocompatible substrate at one side to the heating element, a first temperature sensing element for sensing a temperature at the side where the biocompatible substrate can be exposed to the heating element and a second temperature sensing element for sensing a temperature at the side opposite thereto with respect to the biocompatible substrate. The device also comprises a processing means programmed for calculating at least one heat transfer resistivity value based on temperature values obtained with the first temperature sensing element and the second temperature sensing element and the power for the heating element, for deriving a characteristic of the target DNA and/or RNA bioparticles from said heat transfer resistivity value.
摘要翻译： 公开了用于表征DNA和/或RNA双链体的方法。 生物传感装置包括使用功率并适合于提供靶DNA和/或RNA生物颗粒的热变性的加热元件，适于接收生物相容性底物的样品保持器，其具有涂覆有探针DNA和/或RNA的官能化表面， 可以连接靶DNA和/或RNA双链体，样品保持器还适于将一侧的生物相容性基底暴露于加热元件，第一温度感测元件，用于感测生物相容性基底可以暴露于的一侧的温度 加热元件和第二温度感测元件，用于感测与生物相容性基底相对的一侧的温度。 该装置还包括一个处理装置，其被编程用于基于用第一温度感测元件和第二温度感测元件获得的温度值和加热元件的功率来计算至少一个传热电阻率值，用于导出靶DNA的特征 和/或RNA生物颗粒从所述传热电阻率值。
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公开(公告)号：US20130327656A1
公开(公告)日：2013-12-12
申请号：US13991223
申请日：2011-11-25
IPC分类号： G01N27/02 , G01N27/327
CPC分类号： G01N27/327 , B01L3/50273 , B01L3/502738 , B01L2300/023 , B01L2300/0636 , C12Q1/6825 , C12Q1/6827 , C12Q1/6832 , G01N25/4873 , G01N27/021 , G01N27/3275 , G05B15/02 , Y10T436/11 , Y10T436/143333 , C12Q2527/101 , C12Q2527/113 , C12Q2565/607
摘要： A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value.
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