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    COMPOSITION FOR INHIBITING THE ONSET OF ARTERIOSCLEROSIS AND INHIBITION METHOD
    1.
    发明申请
    COMPOSITION FOR INHIBITING THE ONSET OF ARTERIOSCLEROSIS AND INHIBITION METHOD 审中-公开
    用于抑制肠梗阻和抑制方法的组合物

    公开(公告)号：US20130012459A1

    公开(公告)日：2013-01-10

    申请号：US13547604

    申请日：2012-07-12

    申请人： Masaaki Tokuda ,  Kouji Murao ,  Toshihiko Ishida ,  Ken Izumori

    发明人： Masaaki Tokuda ,  Kouji Murao ,  Toshihiko Ishida ,  Ken Izumori

    IPC分类号： A61K31/7004 ,  A61P9/10

    CPC分类号： A23K20/163 ,  A23L33/10 ,  A61K31/7004

    摘要： A composition for inhibiting the onset of arteriosclerosis is characterized by comprising D-psicose as an active ingredient for an antiatherogenic action. The antiatherogenic action as described above includes an action of inhibiting or reducing the expression of a chemokine or a cytokine related to arteriosclerosis in vivo and an action of promoting the expression of a receptor involved in the improvement of arteriosclerosis without affecting the expression of an arteriosclerosis inducer. This composition is used in the form of a product selected from the group consisting of sweeteners, seasonings, food additives, food materials, foods and drinks, health foods and drinks, drugs, quasi drugs and feeds blended with D-psicose and/or its derivative and/or a mixture thereof as the active ingredient. The method of inhibiting the onset of arteriosclerosis is a method of using the above composition.

    摘要翻译： 用于抑制动脉硬化发作的组合物的特征在于包含D-灵敏蛋白作为抗动脉粥样硬化作用的活性成分。 如上所述的抗动脉粥样硬化作用包括抑制或降低与体内动脉硬化相关的趋化因子或细胞因子的表达的作用，以及促进动脉硬化改善的受体的表达的作用，而不影响动脉硬化诱导剂的表达 。 该组合物以选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料，保健食品和饮料，药物，准药物和掺有D-psicose和/或其混合物的饲料的形式使用 衍生物和/或其混合物作为活性成分。 抑制动脉硬化发生的方法是使用上述组合物的方法。

    Composition for Inhibiting the Onset of Arteriosclerosis and Inhibition Method
    2.
    发明申请
    Composition for Inhibiting the Onset of Arteriosclerosis and Inhibition Method 审中-公开
    用于抑制动脉硬化和抑制方法的组合物

    公开(公告)号：US20080221044A1

    公开(公告)日：2008-09-11

    申请号：US11569548

    申请日：2005-05-26

    申请人： Masaaki Tokuda ,  Kouji Murao ,  Toshihiko Ishida ,  Ken Izumori

    发明人： Masaaki Tokuda ,  Kouji Murao ,  Toshihiko Ishida ,  Ken Izumori

    IPC分类号： A61K31/7004 ,  A61P9/10

    CPC分类号： A23K20/163 ,  A23L33/10 ,  A61K31/7004

    摘要： [Object] To provide a composition for inhibiting the onset of arteriosclerosis by using a rare sugar D-psicose and a method of inhibiting the onset of arteriosclerosis.[Means for Resolution] The composition for inhibiting the onset of arteriosclerosis is characterized by comprising D-psicose as an active ingredient for an antiatherogenic action. The antiatherogenic action as described above includes an action of inhibiting or reducing the expression of a chemokine or a cytokine related to arteriosclerosis in vivo and an action of promoting the expression of a receptor involved in the improvement of arteriosclerosis without affecting the expression of an arteriosclerosis inducer. This composition is used in the form of a product selected from the group consisting of sweeteners, seasonings, food additives, food materials, foods and drinks, health foods and drinks, drugs, quasi drugs and feeds blended with D-psicose and/or its derivative and/or a mixture thereof as the active ingredient. The method of inhibiting the onset of arteriosclerosis is a method of using the above composition.

    摘要翻译： 本发明提供一种通过使用稀有糖D-psicose抑制动脉硬化发作的组合物和抑制动脉硬化发作的方法。 [解决手段]用于抑制动脉硬化发作的组合物的特征在于含有作为抗动脉粥样硬化作用的活性成分的D-灵芝蛋白。 如上所述的抗动脉粥样硬化作用包括抑制或降低与体内动脉硬化相关的趋化因子或细胞因子的表达的作用，以及促进动脉硬化改善的受体的表达的作用，而不影响动脉硬化诱导剂的表达 。 该组合物以选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料，保健食品和饮料，药物，准药物和掺有D-psicose和/或其混合物的饲料的形式使用 衍生物和/或其混合物作为活性成分。 抑制动脉硬化发生的方法是使用上述组合物的方法。

    Utilization of hypertension/hypercardia-preventing effect of D-allose
    7.
    发明授权
    Utilization of hypertension/hypercardia-preventing effect of D-allose 有权
    利用高血压/防高效D-allose的作用

    公开(公告)号：US08440619B2

    公开(公告)日：2013-05-14

    申请号：US12065452

    申请日：2006-08-31

    申请人： Masaaki Tokuda ,  Shoji Kimura ,  Ken Izumori

    发明人： Masaaki Tokuda ,  Shoji Kimura ,  Ken Izumori

    IPC分类号： A61K38/00 ,  A61K9/12 ,  A61K31/70 ,  A61P9/00

    CPC分类号： A23K20/163 ,  A23L33/10 ,  A61K31/7004

    摘要： The object is to provide a novel application of D-allose (e.g., use for prevention of hypertension or hypercardia). Thus, disclosed is a composition for preventing the increase in blood pressure which comprises D-allose as an active ingredient; or a composition containing D-allose and/or a derivative thereof, preferably in an amount of 0.1 to 50% by weight. Preferably, the composition is in a form selected from the group consisting of a food additive, a food material, a beverage/food, a health beverage/food, a pharmaceutical and a feeding stuff which can be used for the prevention and treatment of a cardiovascular system disorder (e.g., hypertension, hypercardia). The increase in blood pressure may be caused by salt-sensitive hypertension. Also disclosed is use of D-allose for preventing the increase in blood pressure (excluding medical practices).

    摘要翻译： 本发明的目的是提供D-丙氨酸的新应用（例如，用于预防高血压或高血压）。 因此，公开了用于防止血压升高的组合物，其包含D-阿洛糖作为活性成分; 或含有D-丙氨酸和/或其衍生物的组合物，优选为0.1〜50重量％。 优选地，组合物为选自食品添加剂，食品材料，饮料/食品，保健饮料/食品，药物和饲料的形式，其可用于预防和治疗 心血管系统疾病（如高血压，高血压）。 血压升高可能是盐敏感性高血压引起的。 还公开了使用D-丙氨酸来防止血压升高（不包括医疗实践）。

    THERMOSTABLE L-RIBOSE ISOMERASE AND METHOD FOR PRODUCING SAME AND USE OF SAME
    8.
    发明申请
    THERMOSTABLE L-RIBOSE ISOMERASE AND METHOD FOR PRODUCING SAME AND USE OF SAME 有权
    可热裂解的L-赖氨酸异构体及其生产方法及其用途

    公开(公告)号：US20090325231A1

    公开(公告)日：2009-12-31

    申请号：US12515596

    申请日：2007-03-26

    申请人： Ken Izumori ,  Kenji Morimoto ,  Goro Takata ,  Masaaki Tokuda ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

    发明人： Ken Izumori ,  Kenji Morimoto ,  Goro Takata ,  Masaaki Tokuda ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

    IPC分类号： C12P21/00 ,  C12N9/90 ,  C12N1/21 ,  C12P19/24

    CPC分类号： C12N9/90 ,  C12P19/24 ,  C12R1/01

    摘要： Object: To provide a thermostable L-ribose isomerase.Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.

    摘要翻译： 目的：提供热稳定的L-核糖异构酶。 解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH 9.0的最佳pH（甘氨酸 - NaOH缓冲液），以及稳定的物理化学性质，例如在pH 9.0的热处理期间温度稳定性高达45℃，为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。 醛糖和酮糖之间的转化方法，包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸解脂耶氏杆菌菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇以使醛糖异构化以产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-果糖，D-甘露糖，D-甘露糖，L-阿洛糖和L-古洛糖。

    Gene sequence of L-rhamnose isomerase having new catalytic function and use thereof
    9.
    发明授权
    Gene sequence of L-rhamnose isomerase having new catalytic function and use thereof 有权
    具有新催化功能的L-鼠李糖异构酶的基因序列及其应用

    公开(公告)号：US07501267B2

    公开(公告)日：2009-03-10

    申请号：US11714887

    申请日：2007-03-07

    申请人： Ken Izumori ,  Goro Takada ,  Masaaki Tokuda

    发明人： Ken Izumori ,  Goro Takada ,  Masaaki Tokuda

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N1/21 ,  C12N9/90

    CPC分类号： C12N9/90 ,  C12P19/02 ,  C12P19/24 ,  C12Y503/01014

    摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.

    摘要翻译： 在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的 。 编码以下蛋白质（a）或（b）的DNA。 上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。 包含SEQ ID NO：2所示的氨基酸序列的蛋白质。 一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。 一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。

    Gene sequence of l-rhamnose isomerase having new catalytic function and use thereof
    10.
    发明申请
    Gene sequence of l-rhamnose isomerase having new catalytic function and use thereof 有权
    具有新催化功能的L-鼠李糖异构酶的基因序列及其用途

    公开(公告)号：US20060148061A1

    公开(公告)日：2006-07-06

    申请号：US10541822

    申请日：2004-01-09

    申请人： Ken Izumori ,  Goro Takada ,  Masaaki Tokuda

    发明人： Ken Izumori ,  Goro Takada ,  Masaaki Tokuda

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12P19/02 ,  C12N9/90 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12N9/90 ,  C12P19/02 ,  C12P19/24 ,  C12Y503/01014

    摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.

    摘要翻译： 在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的 。 编码以下蛋白质（a）或（b）的DNA。 上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。 包含SEQ ID NO：2所示的氨基酸序列的蛋白质。 一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。 一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。