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8 条记录 (耗时 0.026 秒)

    VEGF-binding polypeptide
    1.
    发明授权
    VEGF-binding polypeptide 失效
    VEGF结合多肽

    公开(公告)号：US06270993B1

    公开(公告)日：2001-08-07

    申请号：US09051363

    申请日：1998-07-15

    申请人： Masabumi Shibuya ,  Masaji Okamoto ,  Mikio Niwa ,  Tomoe Matsumoto ,  Makoto Asano ,  Tosiaki Segawa

    发明人： Masabumi Shibuya ,  Masaji Okamoto ,  Mikio Niwa ,  Tomoe Matsumoto ,  Makoto Asano ,  Tosiaki Segawa

    IPC分类号： C07H2104

    CPC分类号： C07K14/71

    摘要： An object of the present invention is to provide a low molecular weight VEGF inhibitor that can be utilized to treat diseases accompanying neovascularization, such as solid tumors. It was found that a polypeptide containing immunoglobulin-like domain 1 and immunoglobulin-like domain 2 but neither immunoglobulin-like main 6 nor immunoglobulin-like domain 7 of the extracellular domain of the VEGF receptor FLT possess VEGF inhibitory activity.

    摘要翻译： 本发明的目的是提供可用于治疗伴随新生血管形成的疾病的低分子量VEGF抑制剂，例如实体瘤。 已经发现，含有免疫球蛋白样结构域1和免疫球蛋白样结构域2但是VEGF受体FLT的细胞外结构域的免疫球蛋白样结构域6和免疫球蛋白样结构域7的多肽均具有VEGF抑制活性。

    VEGF-binding KDR polypeptide
    2.
    发明授权
    VEGF-binding KDR polypeptide 失效
    VEGF结合KDR多肽

    公开(公告)号：US06348333B1

    公开(公告)日：2002-02-19

    申请号：US09142956

    申请日：1999-03-04

    申请人： Mikio Niwa ,  Masaji Okamoto ,  Tomoe Matsumoto ,  Toshiaki Segawa

    发明人： Mikio Niwa ,  Masaji Okamoto ,  Tomoe Matsumoto ,  Toshiaki Segawa

    IPC分类号： C07K1471

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/71 ,  C07K2319/00 ,  C07K2319/30

    摘要： A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.

    摘要翻译： 提供了新的多肽，其可用于治疗伴随新生血管形成的疾病，例如实体瘤，并且可用作低分子量VEGF抑制剂。 该多肽包含VEGF受体KDR的细胞外结构域的免疫球蛋白样结构域1和免疫球蛋白样结构域2。 由于其具有比具有保留VEGF抑制活性的常规多肽更小的分子量，因此预期其可以使用重组DNA技术容易地表达并更快地渗透到患病部位。

    Method of purifying environmental dna and method of efficiently screening for protein-encoding gene from environmental dna
    6.
    发明申请
    Method of purifying environmental dna and method of efficiently screening for protein-encoding gene from environmental dna 审中-公开
    环境dna的纯化方法和有效筛选环境DNA的蛋白质编码基因的方法

    公开(公告)号：US20070184472A1

    公开(公告)日：2007-08-09

    申请号：US11628730

    申请日：2005-06-08

    申请人： Masaji Okamoto ,  Kenichi Tanaka

    发明人： Masaji Okamoto ,  Kenichi Tanaka

    IPC分类号： C40B30/06 ,  C40B40/08 ,  C07H21/04

    CPC分类号： C12N15/101

    摘要： The method of purifying environmental DNA and the method of screening for a gene encoding a functional protein from environmental DNA are provided. DNA from a environmental sample is purified by recovering DNA from an environmental sample and allowing the thus recovered DNA to be subjected to gel filtration chromatography and ion exchange chromatography. In addition, a display library of DNA derived from an environmental sample is created so that screening is carried out in terms of the interaction of the above display library with ligands. Thus, screening of protein-encoding genes can be carried out.

    摘要翻译： 提供了环境DNA的纯化方法和从环境DNA筛选编码功能性蛋白质的基因的方法。 通过从环境样品中回收DNA纯化来自环境样品的DNA，并将这样回收的DNA进行凝胶过滤层析和离子交换层析。 此外，产生来自环境样品的DNA的显示库，以便根据上述显示库与配体的相互作用进行筛选。 因此，可以进行蛋白质编码基因的筛选。