利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.036 秒)

    Packing material for liquid chromatography and process for producing the same
    6.
    发明授权
    Packing material for liquid chromatography and process for producing the same 失效
    液相色谱的包装材料及其制备方法

    公开(公告)号：US06306297B1

    公开(公告)日：2001-10-23

    申请号：US08371205

    申请日：1995-01-11

    申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

    发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

    IPC分类号： B01D1508

    CPC分类号： B01J20/28059 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3021 ,  B01J20/3064 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/58

    摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof. A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 &mgr;m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 &mgr;m. A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca10(PO4)6(OH)2, Ca3(PO4)2, Ca2P2O7, Ca(PO3)2, Ca10(PO4)6F2 and Ca10(PO4)6Cl2, said packing material having a dense structure with a porosity of no more than 5%. A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I): Ca10(PO4)6(OH)2−2xF2x  (I) wherein x is a number of from about 0.1 to 1.

    摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种由包含磷酸钙基化合物的表面的球状基材构成的柱状填充材料。本发明的第二方面涉及包含多孔磷酸钙基颗粒的填充材料，该颗粒具有开孔， 平均孔径为0.01至20μm，所述颗粒由平均尺寸为0.1至10μm的结晶颗粒组成。本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括至少一种 选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3）2，Ca10（PO4）6F2和Ca10（PO4）6Cl2）组成的材料，所述包装材料具有致密结构 孔隙率不超过5％。本发明的第四方面涉及用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：其中x是 数量从大约0.1到1。

    Packing material for liquid chromatography
    7.
    发明授权
    Packing material for liquid chromatography 失效
    液相色谱填充材料

    公开(公告)号：US5039408A

    公开(公告)日：1991-08-13

    申请号：US461854

    申请日：1990-01-08

    申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

    发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

    IPC分类号： B01D15/08 ,  B01J20/04 ,  B01J20/32

    CPC分类号： B01J20/28083 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3236 ,  B01J2220/54

    摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense structure with a porosity of no more than 5%.A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2-2x F.sub.2x (I)wherein x is a number of from about 0.1 to 1.

    摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种柱状填充材料，其由在其表面上具有磷酸钙基化合物的涂层的球形基材构成。 本发明的第二方面涉及一种包含多孔磷酸钙基颗粒的包装材料，其具有平均孔径为0.01至20μm的开放孔，所述颗粒由平均尺寸为0.1-10μm的结晶颗粒组成 。 本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3） 2，Ca10（PO4）6F2和Ca10（PO4）6Cl2，所述包装材料具有孔隙率不超过5％的致密结构。 本发明的第四方面涉及一种用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：Ca10（PO4）6（OH）2-2xF2x（I），其中x是 约0.1至1。

    Separating agent, separator and method of separating cell or virus
    8.
    再颁专利
    Separating agent, separator and method of separating cell or virus 失效
    分离剂，分离器和分离细胞或病毒的方法

    公开(公告)号：USRE35267E

    公开(公告)日：1996-06-11

    申请号：US193760

    申请日：1994-02-03

    申请人： Sumiaki Tsuru ,  Takeshi Ichitsuka ,  Akihiko Yokoo ,  Tsuneo Hiraide

    发明人： Sumiaki Tsuru ,  Takeshi Ichitsuka ,  Akihiko Yokoo ,  Tsuneo Hiraide

    IPC分类号： C12N1/02 ,  C12N7/02 ,  B01D15/00 ,  B01D39/02 ,  B01D39/14

    CPC分类号： C12N7/00 ,  C12N1/02 ,  C12N2710/00051 ,  Y10T436/25375

    摘要： A separating agent which includes a polyvinyl acetal resin having open cell structure and an average pore size of from about 10 to about 1000 micrometers; and, porous calcium phosphate granules having open cell structure, and also having two distributions of pore size wherein one distribution has micropores ranging from about 20 to about 500 mm in average pore size and the other distribution has small pores ranging from about 1 to about 50 micrometers in average pore size. Alternatively, the separating agent includes a polyvinyl acetal resin having open cell structure and having an average pore size of from about 10 to about 1000 micrometers as a first element, and a layer of porous calcium phosphate granules having an average granule size of from about 10 to about 2000 micrometers as a second element applied onto the first element. The separating agents may be used in a separator, and may be employed in separating methods. The separating agents, separator, and separating methods can be advantageously used to isolate a target cell or virus from a biological fluid in the fields of medical science and biochemistry. The distribution of target cell or virus subsets is not altered by the separation.

    摘要翻译： 一种分离剂，其包含具有开孔形式的平均孔径为约10至约1000微米的聚乙烯醇缩醛树脂; 和具有开孔结构的多孔磷酸钙颗粒，并且还具有两个孔径分布，其中一个分布的平均孔径为约20至约500mm的微孔，另一分布具有约1至约50的小孔 微米的平均孔径。 或者，分离剂包括具有开孔结构并具有作为第一元素的约10至约1000微米的平均孔径的聚乙烯醇缩醛树脂和平均颗粒尺寸为约10的多孔磷酸钙颗粒层 至约2000微米，作为施加到第一元件上的第二元件。 分离剂可以用于分离器中，并且可以用于分离方法中。 分离剂，分离器和分离方法可以有利地用于在医学和生物化学领域从生物流体中分离靶细胞或病毒。 目标细胞或病毒子集的分布不会因分离而改变。