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公开(公告)号：US5436401A
公开(公告)日：1995-07-25
申请号：US244818
申请日：1994-06-13
IPC分类号： A61K31/59 , A61P3/02 , A61P5/12 , A61P29/00 , A61P35/00 , C07C401/00 , C07J7/00 , C07J51/00 , C07J71/00 , C07J3/00 , C07J75/00
CPC分类号： C07C401/00 , C07J51/00 , C07J7/007 , C07J71/0042
摘要： A 22-oxacholecalciferol derivative represented by formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group; and R.sub.2 and R.sub.3, which may be the same or different, each represent a lower alkyl group having from 1 to 5 carbon atoms,and a process for preparing the same are disclosed. The compound of the present invention has potent differentiation inducing activity and cell proliferation inhibitory activity and is expected to be useful as an anti-tumor agent, an antirheumatic, a treating agent for psoriasis, and a treating agent for hyperparathyreosis. The process of the present invention makes it possible to efficiently produce a desired 22-oxacholecalciferol derivative while reducing by-production.
摘要翻译： PCT No.PCT / JP92 / 01662 Sec。 371日期1994年6月13日 102（e）日期1994年6月13日PCT 1992年12月18日PCT PCT。 公开号WO93 / 12083 日本6月24日，1993.由式（I）表示的22-氧代胆钙化甾醇衍生物：其中R 1表示氢原子或羟基; 并且可以相同或不同的R 2和R 3各自表示具有1至5个碳原子的低级烷基，并且公开了其制备方法。 本发明的化合物具有有效的分化诱导活性和细胞增殖抑制活性，并且预期可用作抗肿瘤剂，抗风湿剂，牛皮癣治疗剂和用于高血糖病的治疗剂。 本发明的方法使得有可能有效地产生所需的22-氧代消化胆钙化醇衍生物，同时减少副产物。
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公开(公告)号：US07837699B2
公开(公告)日：2010-11-23
申请号：US11485561
申请日：2006-07-12
申请人： Norihiro Yamada , Hiroyuki Takahashi , Haruhiko Ueno , Hiroyoshi Watanabe , Keita Suzuki , Takeaki Nakamura
发明人： Norihiro Yamada , Hiroyuki Takahashi , Haruhiko Ueno , Hiroyoshi Watanabe , Keita Suzuki , Takeaki Nakamura
CPC分类号： A61B17/320092 , A61B2017/0034
摘要： An ultrasonic treatment apparatus includes a sheath having an opening at a distal end thereof; an ultrasonic transducer provided at a distal portion of the sheath and generating ultrasonic vibration; an ultrasonic transmission member connected to the ultrasonic transducer at a proximal end thereof, transmitting the ultrasonic vibration, and provided with a treatment part at a distal end thereof; a gripper moving to the treatment part and grasping the part to be treated between the gripper and the treatment part; a link member connected to the gripper and provided on a side of the ultrasonic transmission member; a manipulator part connected to a proximal end part of the link member to open and close the gripper; and a rigid member which the ultrasonic transducer is inserted into and secured to.
摘要翻译： 超声波处理装置包括在其远端具有开口的护套; 设置在护套的远端部分并产生超声波振动的超声换能器; 在超声波传感器的近端处连接到超声波换能器，发送超声波振动，在其远端设置有处理部; 夹持器移动到处理部分并且抓握夹持器和处理部件之间待处理部件; 连接构件，连接到所述夹持器并设置在所述超声波传递构件的一侧; 连接到所述连杆构件的近端部分以打开和关闭所述夹持器的操纵器部件; 以及超声波换能器插入并固定到其上的刚性构件。
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3.发明申请METHOD FOR PRODUCING UNSATURATED CARBOXYLIC ACID-MODIFIED VINYL ALCOHOL POLYMER, AND GAS BARRIER FILM OR GAS BARRIER LAMINATE USING THE SAME 有权用于生产不饱和羧酸改性的乙烯醇聚合物的方法，以及使用其的气体阻隔膜或气体阻挡层压板公开(公告)号：US20090324836A1
公开(公告)日：2009-12-31
申请号：US12302993
申请日：2007-05-31
申请人： Kou Tsurugi , Yoshihisa Inoue , Isao Hara , Hiroyoshi Watanabe , Tomoyoshi Hakamata , Akira Nomoto , Osamu Nakamura
发明人： Kou Tsurugi , Yoshihisa Inoue , Isao Hara , Hiroyoshi Watanabe , Tomoyoshi Hakamata , Akira Nomoto , Osamu Nakamura
IPC分类号： B05D3/10 , C08F220/06 , C08K5/09
摘要： The present invention provides an industrially advantageous method for producing an unsaturated carboxylic acid-modified vinyl alcohol polymer, and a gas barrier film obtained by using the same. In summary of the present invention, the present invention is a method for producing a solution containing at least an unsaturated carboxylic acid-modified vinyl alcohol polymer characterized by reacting a vinyl alcohol polymer and an unsaturated carboxylic acid compound in the presence of an acid catalyst soluble in the reaction system or a solid acid catalyst, and a gas barrier film obtained by using the same, and an example of a representative constitution thereof is a method for producing a solution (A) containing an unsaturated carboxylic acid-modified vinyl alcohol polymer (b), the method comprising following two steps of: (1) a reaction step in which the unsaturated carboxylic acid-modified vinyl alcohol polymer (b) is formed by reacting a vinyl alcohol polymer and an unsaturated carboxylic acid compound (a) in the presence of an acid catalyst soluble in the reaction system; and (2) an ion exchange step in which at least the acid catalyst of acidic compounds is removed by an anion exchange resin.
摘要翻译： 本发明提供了用于制备不饱和羧酸改性的乙烯醇聚合物的工业上有利的方法，以及通过使用它们得到的阻气膜。 本发明概述本发明是一种生产含有至少不饱和羧酸改性的乙烯醇聚合物的溶液的方法，其特征在于在酸催化剂可溶的存在下使乙烯醇聚合物与不饱和羧酸化合物反应 在反应体系或固体酸催化剂中使用的气体阻隔膜，其代表性构成的实施例是含有不饱和羧酸改性乙烯醇系聚合物（A）的溶液（A）的制造方法， b），该方法包括以下两个步骤：（1）反应步骤，其中不饱和羧酸改性的乙烯醇聚合物（b）通过乙烯醇聚合物和不饱和羧酸化合物（a）在 存在可溶于反应体系的酸催化剂; 和（2）离子交换步骤，至少酸性化合物的酸催化剂通过阴离子交换树脂除去。
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公开(公告)号：US20050027310A1
公开(公告)日：2005-02-03
申请号：US10842934
申请日：2004-05-10
申请人： Norihiro Yamada , Haruhiko Ueno , Hiroyuki Takahashi , Hiroyoshi Watanabe , Keita Suzuki , Mitsumasa Okada , Takeaki Nakamura
发明人： Norihiro Yamada , Haruhiko Ueno , Hiroyuki Takahashi , Hiroyoshi Watanabe , Keita Suzuki , Mitsumasa Okada , Takeaki Nakamura
CPC分类号： A61B1/042 , A61B1/0051 , A61B17/22012 , A61B17/320092 , A61B2017/22021 , A61B2090/373
摘要： An ultrasonic treatment apparatus comprises an endoscope having an insertion portion to be inserted in a body cavity, and a treatment unit having an ultrasonic vibrator which generates ultrasonic vibrations, and a treatment portion which performs treatment by utilizing the ultrasonic vibrations generated by the ultrasonic vibrator. The ultrasonic treatment apparatus further comprises a treatment unit holding portion, which is provided in a distal end portion of the insertion portion and to which the treatment unit is attached, a cable which transmits an electric signal to the ultrasonic vibrator, and at least one bundle member which bundles the insertion portion and the cable.
摘要翻译： 一种超声波处理装置，其特征在于，包括具有插入体腔内的插入部的内窥镜和具有产生超声波振动的超声波振动器的处理部，以及利用超声波振子产生的超声波振动进行处理的处理部。 所述超声波处理装置还包括处理单元保持部，所述处理单元保持部设置在所述插入部的前端部，并且所述处理单元被安装在所述处理单元的前端部，将电信号发送到所述超声波振动器的电缆以及至少一个束 将插入部分和电缆捆绑的部件。
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公开(公告)号：US5497208A
公开(公告)日：1996-03-05
申请号：US304501
申请日：1994-09-09
申请人： Yu Sato , Kazutoshi Shiratori , Hiroyoshi Watanabe
发明人： Yu Sato , Kazutoshi Shiratori , Hiroyoshi Watanabe
摘要： A camera having a lens shutter mechanism in accordance with the present invention comprises sectors lying in a lens frame and forming a predetermined exposure aperture, a drive ring for opening and closing the sectors, a high-speed sector opening lever and a low-speed sector opening lever which drive the drive ring through an interlock lever, a plurality of springs having different strengths and constraining the high-speed sector opening lever and low-speed sector opening lever, a sector closing lever for driving the high-speed sector opening lever and low-speed sector opening lever in a direction causing the sectors to close, a mode changing member for changing shutter speeds by selecting whether both or either of the high-speed sector opening lever and low-speed sector opening lever should be driven, a charge cam gear for resetting the shutter mechanism to an initial position after exposure is completed, and a groove bored along the optical axis in a camera body and designed to guide the drive ring along the optical axis when the lens frame collapses and to restrain the drive ring from rotating about the optical axis after the lens frame completes collapsing. Only a minimum number of required members are disposed in a lens frame and the remaining members are arranged in a camera body. This results in a compact camera.
摘要翻译： 具有根据本发明的透镜快门机构的相机包括位于透镜框架中并形成预定曝光孔的扇形，用于打开和关闭扇形的驱动环，高速扇形开启杆和低速扇区 通过互锁杆驱动驱动环的开启杆，具有不同强度并限制高速扇形开启杆和低速扇形开启杆的多个弹簧，用于驱动高速扇形开启杆的扇区闭合杆，以及 低速扇区打开杆在使扇区闭合的方向上，通过选择是否应该驱动高速扇区开启杆和低速扇形开启杆中的任一个来改变快门速度的模式改变构件，充电 凸轮齿轮，用于在曝光完成之后将快门机构复位到初始位置，以及在照相机机身中沿着光轴钻孔并设计成引导 当透镜框塌陷时沿着光轴的驱动环，并且在透镜框架完成塌缩之后，限制驱动环围绕光轴旋转。 只有最少数量的所需构件被布置在透镜框架中，并且其余构件被布置在照相机主体中。 这导致了一个紧凑的相机。
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公开(公告)号：US07455641B2
公开(公告)日：2008-11-25
申请号：US10842934
申请日：2004-05-10
申请人： Norihiro Yamada , Haruhiko Ueno , Hiroyuki Takahashi , Hiroyoshi Watanabe , Keita Suzuki , Mitsumasa Okada , Takeaki Nakamura
发明人： Norihiro Yamada , Haruhiko Ueno , Hiroyuki Takahashi , Hiroyoshi Watanabe , Keita Suzuki , Mitsumasa Okada , Takeaki Nakamura
CPC分类号： A61B1/042 , A61B1/0051 , A61B17/22012 , A61B17/320092 , A61B2017/22021 , A61B2090/373
摘要： An ultrasonic treatment apparatus comprises an endoscope having an insertion portion to be inserted in a body cavity, and a treatment unit having an ultrasonic vibrator which generates ultrasonic vibrations, and a treatment portion which performs treatment by utilizing the ultrasonic vibrations generated by the ultrasonic vibrator. The ultrasonic treatment apparatus further comprises a treatment unit holding portion, which is provided in a distal end portion of the insertion portion and to which the treatment unit is attached, a cable which transmits an electric signal to the ultrasonic vibrator, and at least one bundle member which bundles the insertion portion and the cable.
摘要翻译： 一种超声波处理装置，其特征在于，包括具有插入体腔内的插入部的内窥镜和具有产生超声波振动的超声波振动器的处理部，以及利用超声波振子产生的超声波振动进行处理的处理部。 所述超声波处理装置还包括处理单元保持部，所述处理单元保持部设置在所述插入部的前端部，并且所述处理单元被安装在所述处理单元的前端部，将电信号发送到所述超声波振动器的电缆以及至少一个束 将插入部分和电缆捆绑的部件。
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公开(公告)号：US20060224162A1
公开(公告)日：2006-10-05
申请号：US11446999
申请日：2006-06-05
申请人： Keita Suzuki , Keiichi Arai , Hiroyoshi Watanabe , Tsutomu Okada
发明人： Keita Suzuki , Keiichi Arai , Hiroyoshi Watanabe , Tsutomu Okada
IPC分类号： A61D1/12
CPC分类号： A61B17/29 , A61B1/00133 , A61B2017/00398
摘要： This endoscopic treatment system is provided with an insertion-retraction and rotating device for a treatment tool, which performs an insertion-retraction operation along a direction of an axis of a treatment tool and a rotating operation around the axis, of the treatment tool inserted in a channel of an endoscope.
摘要翻译： 该内窥镜治疗系统设置有用于治疗工具的插入回缩和旋转装置，该治疗工具沿着治疗工具的轴线的方向和围绕轴线的旋转操作执行插入式治疗工具的插入回缩操作 内窥镜的通道。
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公开(公告)号：US20050049633A1
公开(公告)日：2005-03-03
申请号：US10890754
申请日：2004-07-14
申请人： Hiroyoshi Watanabe
发明人： Hiroyoshi Watanabe
IPC分类号： A61B18/12 , A61B1/005 , A61B10/00 , A61B10/06 , A61B17/00 , A61B17/28 , A61B17/42 , A61B18/14
CPC分类号： A61B17/29 , A61B10/06 , A61B18/1445 , A61B2017/00269 , A61B2017/2808 , A61B2017/2926 , A61B2017/2939 , A61B2018/00595
摘要： A hemostatic forceps for an endoscope has a support section for supporting the pair of clamp pieces and so that they can rotate and change their distal parts direction. The pair of clamp pieces and are formed in tapered shape so that widths of the pair of clamp pieces gradually decrease in a direction from a side of the support section to a side of the distal parts. Length of the pair of clamp pieces at arbitrary location along the direction from a side of the support section to the distal sides, times the width of the pair of clamp pieces at the same location, is set to be substantially constant.
摘要翻译： 用于内窥镜的止血钳具有用于支撑所述一对夹具的支撑部，并且能够旋转并改变其远端部的方向。 一对夹持件形成为锥形，使得一对夹持件的宽度在从支撑部分的侧面到远端部分的方向上逐渐减小。 沿着从支撑部分的侧面到远侧的方向的任意位置处的一对夹具的长度被设置为基本上恒定。
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公开(公告)号：US06861534B2
公开(公告)日：2005-03-01
申请号：US10203937
申请日：2001-12-27
申请人： Katsuhiko Matsuba , Takazou Katou , Satoshi Inoki , Hiroyoshi Watanabe , Takashi Ohkawa , Masato Yamazaki , Michio Iwama
发明人： Katsuhiko Matsuba , Takazou Katou , Satoshi Inoki , Hiroyoshi Watanabe , Takashi Ohkawa , Masato Yamazaki , Michio Iwama
IPC分类号： C07D233/32 , C07D233/34 , C07D233/74 , C07D233/06
CPC分类号： C07D233/34 , C07D233/32 , Y02P20/582
摘要： There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50° C. or higher to give 1,3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A), a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1,3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide.The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.
摘要翻译： 提供了使用（A）二氧化碳和单烷基胺中的至少一种作为第一成分使用烯化氧制备1,3-二烷基-2-咪唑啉酮的方法; （B）一烷基胺的二氧化碳化合物; 和（C）1,3-二烷基脲，通过在50℃或更高温度下加热使第一和第二组分反应，得到1,3-二烷基-2-咪唑啉酮，其特征在于摩尔进料量的总摩尔量 的组分（A）中所含的单烷基胺，单烷基胺的二烷基胺部分（B）的单烷基胺部分的摩尔进料量和1,3-二烷基脲，组分（ C）为环氧烷的摩尔进料量的至少三倍。本发明的制备方法使用工业上容易获得的环氧烷作为原料，并且可以以工业规模更高的产率适当地进行。
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10.发明授权
公开(公告)号：US5452035A
公开(公告)日：1995-09-19
申请号：US103897
申请日：1993-08-06
申请人： Hiroyoshi Watanabe , Masaki Nagao , Shinichi Kodama , Junichi Ito
发明人： Hiroyoshi Watanabe , Masaki Nagao , Shinichi Kodama , Junichi Ito
CPC分类号： G03B17/30 , G03B2217/261
摘要： A Patrone and a camera using the Patrone. The Patrone comprises a film wind spool arranged in a cylindrical body, of which upper and lower ends are light-tightly sealed. The body stores film so that the film can move freely in or out of the body in such a manner that the film can rotate freely, and is wound about said spool in roll form. Locking members are arranged in the cylindrical body and can be displaced freely relative to the spool. Ends of the locking members normally project outwardly from the cylindrical body. Locked members are arranged opposed to said locking members and are formed substantially as parts of one of the cylindrical body or spool. An elastic member normally urges each of the locked members toward engagement with an associated locking member. A camera includes an unlocking member which presses the locking members of the Patrone to displace them against the force of the elastic member when the Patrone is mounted in a camera thereby disengaging the locking members from the locked members and enabling the spool to rotate freely.
摘要翻译： Patrone和使用Patrone的相机。 Patrone包括一个布置在圆柱体中的薄膜卷轴，其上端和下端被轻轻地密封。 身体存储胶片，使得胶片可以以这样的方式自由地移动或移出身体，使得胶片可以自由地旋转，并且以卷状缠绕在所述卷轴上。 锁定构件布置在圆柱体中并且可相对于线轴自由移位。 锁定构件的端部通常从圆柱体向外突出。 锁定构件布置成与所述锁定构件相对并且基本上形成为圆柱形主体或线轴中的一个的部件。 弹性构件通常促使每个锁定构件与相关联的锁定构件接合。 照相机包括解锁构件，当Patrone安装在照相机中时，按下Patrone的锁定构件以使其抵抗弹性构件的力移位，从而使锁定构件与锁定构件脱离接合并使线轴自由旋转。
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