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    Process for producing amino acid derivative from hydroxyimino acid
    3.
    发明授权
    Process for producing amino acid derivative from hydroxyimino acid 失效
    从羟肟酸生产氨基酸衍生物的方法

    公开(公告)号：US08043836B2

    公开(公告)日：2011-10-25

    申请号：US11576421

    申请日：2005-09-29

    申请人： Masakazu Sugiyama ,  Kunihiko Watanabe ,  Tadashi Takemoto ,  Kenichi Mori

    发明人： Masakazu Sugiyama ,  Kunihiko Watanabe ,  Tadashi Takemoto ,  Kenichi Mori

    IPC分类号： C12P1/00 ,  C12P13/04 ,  C12P13/22 ,  C12P17/10 ,  C07D209/18

    CPC分类号： C12P13/227 ,  C12P13/04 ,  C12R1/01 ,  C12R1/185 ,  C12R1/19

    摘要： The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I): wherein R1 represents an optionally substituted predetermined hydrocarbon group; R2 represents a C1 to C3 alkyl group or a hydrogen atom; and n is 0 or 1, to produce an amino acid derivative represented by the following general formula (III): wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.

    摘要翻译： 本发明提供一种工业上有利的氨基酸衍生物的制备方法。 本发明提供一种生产氨基酸衍生物的方法，其包括使微生物和/或酶与由以下通式（I）表示的肟基酸接触：其中R1表示任选取代的预定烃基; R2表示C1〜C3烷基或氢原子; 和n为0或1，以产生由以下通式（III）表示的氨基酸衍生物：其中R 1和n与通式（I）中的R 1和n的含义相同，其中微生物和/ 或者酶能够催化反应。

    METHOD FOR PRODUCING SERINE DERIVATIVE AND PROTEIN USED FOR THE SAME
    4.
    发明申请
    METHOD FOR PRODUCING SERINE DERIVATIVE AND PROTEIN USED FOR THE SAME 有权
    生产用于其的丝氨酸衍生物和蛋白质的方法

    公开(公告)号：US20100317068A1

    公开(公告)日：2010-12-16

    申请号：US12836984

    申请日：2010-07-15

    申请人： Shinji Kuroda ,  Masakazu Sugiyama ,  Kunihiko Watanabe ,  Shunichi Suzuki ,  Kenzo Yokozeki ,  Tatsuki Kashiwagi

    发明人： Shinji Kuroda ,  Masakazu Sugiyama ,  Kunihiko Watanabe ,  Shunichi Suzuki ,  Kenzo Yokozeki ,  Tatsuki Kashiwagi

    IPC分类号： C12P13/06 ,  C07H21/00 ,  C12N9/10 ,  C12N1/21

    CPC分类号： C12N9/1029 ,  C12P13/04

    摘要： The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.

    摘要翻译： 本发明描述了通过方便的技术产生丝氨酸衍生物和光学活性异构体的方法，以及在该方法中有用的酶等。 在具有酶活性的下列蛋白质（A）和/或（B）的存在下，α-氨基酸与醛反应形成丝氨酸衍生物：（A）包含SEQ ID NO：1的氨基酸序列的蛋白质 （B）包含SEQ ID NO：5的氨基酸序列但包括取代，缺失，插入和加入一个或多个氨基酸的蛋白质，并且能够催化该反应以形成丝氨酸衍生物 。