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公开(公告)号：US5462799A
公开(公告)日：1995-10-31
申请号：US293817
申请日：1994-08-22
CPC分类号： D01F11/16 , D01F11/14 , Y10T428/2913 , Y10T428/2918 , Y10T428/2933 , Y10T428/2964 , Y10T428/2971
摘要： Carbon fibers with a surface oxygen concentration (O/C ratio) of 0.20 or less as measured by X-ray photoelectron spectroscopy, a surface concentration of hydroxyl groups (C--OH/C ratio) of 0.5% or greater as measured by chemical modification X-ray photoelectron spectroscopy and a surface concentration of carboxylic groups (COOH/C ratio) of 2.0% or less as measured by chemical modification X-ray photoelectron spectroscopy, and comprising applied as a sizing agent an aliphatic compound which has multiple epoxy groups or an aromatic compound which has multiple epoxy groups, the number of atoms between the epoxy groups and an aromatic ring being 6 or greater. They are prepared by electrolyzing a carbon fiber in an alkaline aqueous solution, or electrolyzing a carbon fiber in an acidic aqueous solution followed by washing with an alkaline aqueous solution, and then applying a sizing agent of an aliphatic compound with multiple epoxy groups or an aromatic compound with multiple epoxy groups in which the number of atoms between the epoxy groups and an aromatic ring is 6 or greater. Alternatively, they are prepared by electrolyzing a carbon fiber in an aqueous solution of an ammonium salt and then applying a sizing agent of an aliphatic compound with multiple epoxy groups or an aromatic compound with multiple epoxy groups in which the number of atoms between the epoxy groups and an aromatic ring is 6 or greater.
摘要翻译： 通过X射线光电子能谱测定，表面氧浓度（O / C比）为0.20以下的碳纤维，通过化学改性测定的羟基的表面浓度（C-OH / C比）为0.5％以上 通过化学修饰X射线光电子能谱法测定的X射线光电子能谱和羧基的表面浓度（COOH / C比）为2.0％以下，并且包括作为上浆剂应用具有多个环氧基的脂肪族化合物或 具有多个环氧基的芳族化合物，环氧基和芳香环之间的原子数为6以上。 它们是通过在碱性水溶液中电解碳纤维，或在酸性水溶液中电解碳纤维，然后用碱性水溶液洗涤来制备的，然后施加具有多个环氧基或芳香族的脂族化合物的施胶剂 具有多个环氧基的化合物，其中环氧基和芳环之间的原子数为6以上。 或者，它们通过在铵盐水溶液中电解碳纤维，然后将具有多个环氧基的脂肪族化合物或具有多个环氧基的芳族化合物的施胶剂，其中环氧基团之间的原子数 芳环为6以上。
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公开(公告)号：US5587240A
公开(公告)日：1996-12-24
申请号：US462753
申请日：1995-06-05
CPC分类号： D01F11/16 , D01F11/14 , Y10T428/2913 , Y10T428/2918 , Y10T428/2933 , Y10T428/2964 , Y10T428/2971
摘要： Carbon fibers with a surface oxygen concentration (O/C ratio) of 0.20 or less as measured by X-ray photoelectron spectroscopy, a surface concentration of hydroxyl groups (C-OH/C ratio) of 0.5% or greater as measured by chemical modification X-ray photoelectron spectroscopy and a surface concentration of carboxylic groups (COOH/C ratio) of 2.0% or less as measured by chemical modification X-ray photoelectron spectroscopy, and an aliphatic compound applied as a sizing agent which has multiple epoxy groups or an aromatic compound which has multiple epoxy groups, the number of atoms between the epoxy groups and an aromatic ring being 6 or greater.
摘要翻译： 通过X射线光电子能谱测定，表面氧浓度（O / C比）为0.20以下的碳纤维，通过化学改性测定的羟基的表面浓度（C-OH / C比）为0.5％以上 通过化学修饰X射线光电子能谱法测定的X射线光电子能谱和羧基的表面浓度（COOH / C比）为2.0％以下，作为上胶剂使用的脂肪族化合物，其具有多个环氧基或 具有多个环氧基的芳香族化合物，环氧基和芳香环之间的原子数为6以上。
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公开(公告)号：US5691055A
公开(公告)日：1997-11-25
申请号：US661323
申请日：1996-06-13
CPC分类号： D01F11/16 , D01F11/14 , Y10T428/2913 , Y10T428/2918 , Y10T428/2933 , Y10T428/2964 , Y10T428/2971
摘要： Carbon fibers with a surface oxygen concentration (O/C ratio) of 0.20 or less as measured by X-ray photoelectron spectroscopy, a surface concentration of hydroxyl groups (C--OH/C ratio) of 0.5% or greater as measured by chemical modification X-ray photoelectron spectroscopy and a surface concentration of carboxylic groups (COOH/C ratio) of 2.0% or less as measured by chemical modification X-ray photoelectron spectroscopy, and an aliphatic compound applied as a sizing agent which has multiple epoxy groups or an aromatic compound which has multiple epoxy groups, the number of atoms between the epoxy groups and an aromatic ring being 6 or greater.
摘要翻译： 通过X射线光电子能谱测定，表面氧浓度（O / C比）为0.20以下的碳纤维，通过化学改性测定的羟基的表面浓度（C-OH / C比）为0.5％以上 通过化学修饰X射线光电子能谱法测定的X射线光电子能谱和羧基的表面浓度（COOH / C比）为2.0％以下，作为上胶剂使用的脂肪族化合物，其具有多个环氧基或 具有多个环氧基的芳香族化合物，环氧基和芳香环之间的原子数为6以上。
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公开(公告)号：US5589055A
公开(公告)日：1996-12-31
申请号：US460917
申请日：1995-06-05
CPC分类号： D01F11/16 , D01F11/14 , Y10T428/2913 , Y10T428/2918 , Y10T428/2933 , Y10T428/2964 , Y10T428/2971
摘要： A process for preparing carbon fibers including electrolyzing a carbon fiber in an alkaline aqueous solution, or electrolyzing a carbon fiber in an acidic aqueous solution followed by washing with an alkaline aqueous solution, and then applying a sizing agent of an aliphatic compound with multiple epoxy groups or an aromatic compound with multiple epoxy groups in which the number of atoms between the epoxy groups and an aromatic ring is 6 or greater. Alternatively, the carbon fibers are prepared by electrolyzing a carbon fiber in an aqueous solution of an ammonium salt and then applying a sizing agent of an aliphatic compound with multiple epoxy groups or an aromatic compound with multiple epoxy groups in which the number of atoms between the epoxy groups and an aromatic ring is 6 or greater.
摘要翻译： 一种制备碳纤维的方法，包括在碱性水溶液中电解碳纤维，或在酸性水溶液中电解碳纤维，然后用碱性水溶液洗涤，然后施加具有多个环氧基团的脂族化合物的施胶剂 或具有多个环氧基的芳族化合物，其中环氧基和芳香环之间的原子数为6以上。 或者，碳纤维是通过在铵盐水溶液中电解碳纤维，然后将具有多个环氧基的脂肪族化合物或具有多个环氧基的芳族化合物的上浆剂， 环氧基和芳香环为6以上。
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公开(公告)号：US5910456A
公开(公告)日：1999-06-08
申请号：US702726
申请日：1996-09-09
CPC分类号： C08J5/042 , C08J5/24 , C08J2363/00 , Y10S428/902 , Y10T428/30 , Y10T442/2984 , Y10T442/608 , Y10T442/674
摘要： There is disclosed a prepreg including noncircular cross-section carbon fibers and a matrix resin having a flexural elastic modulus of 2.7 GPa or more and a water absorption of 3.4% or less under hot-wet conditions after curing; and another prepreg including carbon fibers and a matrix resin having an open-hole compression strength under hot-wet conditions and a compression strength after impact under room-temperature conditions of a quasi-isotropic material after curing of each 275 MPa or more. Carbon fiber-reinforced composite materials produced by curing these prepregs are excellent in open-hole compression strength under hot-wet conditions and in compression strength after impact, and can be suitably used especially as an aircraft primary structure material.
摘要翻译： PCT No.PCT / JP96 / 00014 Sec。 371日期1996年9月9日 102（e）1996年9月9日PCT 1996年1月9日PCT PCT。 公开号WO96 / 21695 日期1996年7月18日在固化后的热湿条件下，公开了包括非圆形横截面碳纤维和基体树脂的预浸料，其弯曲弹性模量为2.7GPa以上，吸水率为3.4％以下。 另外，在275MPa以上的固化后，在室温条件下，在热湿条件下具有开孔压缩强度的基体树脂和冲击后的压缩强度的另一种预浸料坯。 通过固化这些预浸料制备的碳纤维增强复合材料在热湿条件下的开孔压缩强度和冲击后的抗压强度优异，可以特别适用于飞机初级结构材料。
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公开(公告)号：US4851304A
公开(公告)日：1989-07-25
申请号：US179286
申请日：1988-04-08
申请人： Kishio Miwa , Kazuharu Shimizu , Hiroaki Fukui
发明人： Kishio Miwa , Kazuharu Shimizu , Hiroaki Fukui
IPC分类号： H01M4/96
CPC分类号： H01M4/96
摘要： A porous electrode substrate for fuel cell and a process for producing the same, which contains 35 to 60% carbonized resin by weight, and has pores with a mean pore size of 20 to 60 .mu.m and a porosity of 60 to 80%, and a compression ratio of 20% or less. Chopped carbon fibers with fiber lengths of 3 to 20 mm and fiber diameters of 4 to 9 .mu.m are dispersed in random directions within substantially 2-dimensional plane, and bound with an organic binder to make an carbon fiber mat. The carbon fiber mat is impregnated with a resin to make prepreg and hot pressing the prepreg under a temperature of 120.degree. to 200.degree. C. and a pressure of 2 to 10 kg/cm.sup.2. Then, the press molded product is carbonized by heat treatment under a temperature of 1300.degree. to 3000.degree. C. in an inert atmosphere or in vacuum to obtain an electrode substrate excellent in various characteristics such as gas permeability, flexural strength, compression strength, etc. Further, for improvement of electroconductivity, it is preferable to use a mixture of a curable resin and a non-curable resin as the resin impregnated into the carbon fiber mat.
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公开(公告)号：US09873916B2
公开(公告)日：2018-01-23
申请号：US14113776
申请日：2012-04-25
申请人： Akira Myomoto , Satoko Kozono , Fumiaki Sato , Masakazu Toi , Takayuki Ueno , Zhipeng Wang , Gozoh Tsujimoto , Kazuharu Shimizu
发明人： Akira Myomoto , Satoko Kozono , Fumiaki Sato , Masakazu Toi , Takayuki Ueno , Zhipeng Wang , Gozoh Tsujimoto , Kazuharu Shimizu
IPC分类号： C12Q1/68 , A61K39/395 , C07K16/32 , A61K39/00
CPC分类号： C12Q1/6886 , A61K39/39558 , A61K2039/505 , C07K16/32 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , A61K2300/00
摘要： This invention relates to a composition and a method for prediction of a response to Trastuzumab therapy in a breast cancer patient, and more specifically, a composition, a kit, a DNA chip, and a method for predicting a response to Trastuzumab therapy by using polynucleotides each comprising a nucleotide sequence represented by any of SEQ ID NOs: 1 to 9, 11 to 19, and 21 to 23 in the Sequence Listing or a nucleotide sequence derived therefrom by substitution of u with t, mutants thereof, derivatives thereof, or fragments thereof comprising at least 16 continuous nucleotides, or a polynucleotide comprising a complementary sequence thereof, and using an increase or decrease in Her2 protein expression level as an indicator.
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公开(公告)号：US5372990A
公开(公告)日：1994-12-13
申请号：US856964
申请日：1992-05-20
申请人： Hitoshi Nobumasa , Kazuharu Shimizu
发明人： Hitoshi Nobumasa , Kazuharu Shimizu
IPC分类号： C01G3/00 , C01G1/00 , C01G15/00 , C01G21/00 , C01G29/00 , C30B29/68 , H01B12/00 , H01L39/12 , H01L31/12
CPC分类号： H01L39/126 , Y10S505/775 , Y10S505/776 , Y10S505/777 , Y10S505/778 , Y10S505/779 , Y10S505/78 , Y10S505/781 , Y10S505/782 , Y10S505/783
摘要： Provided is an oxide superconductor in which superconducting layer is sandwiched between two blocking layers having different compositions. Available superconducting layers include a one-layer system having one Cu-O.sub.2 sheet, a two-layer system having a mediating layer sandwiched between two Cu-O.sub.2 sheets, and a three-layer system having mediating layers sandwiched individually between three Cu-O.sub.2 sheets.Since the blocking layers are of different compositions, seventy-seven kinds of oxide superconductors can be obtained.
摘要翻译： PCT No.PCT / JP91 / 01255 Sec。 371日期：1992年5月20日 102（e）日期1992年5月20日PCT 1991年9月20日PCT PCT。 出版物WO92 / 05114 日期为1992年4月2日。提供了一种氧化物超导体，其中超导层夹在具有不同组成的两个阻挡层之间。 可用的超导层包括具有一个Cu-O 2片的单层系统，具有夹在两个Cu-O 2片之间的介体层的两层系统以及三层系统，其中介层分别夹在三个Cu-O 2片之间 。 由于阻挡层具有不同的组成，因此可以获得七十七种氧化物超导体。
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公开(公告)号：US4770929A
公开(公告)日：1988-09-13
申请号：US92398
申请日：1987-09-02
申请人： Hitoshi Nobumasa , Kazuharu Shimizu
发明人： Hitoshi Nobumasa , Kazuharu Shimizu
CPC分类号： B32B5/28 , Y10T428/2918 , Y10T428/30 , Y10T442/3789 , Y10T442/3813
摘要： A light-weight composite material having a laminated structure comprises at least one porous fiber layer constructed of reinforcing short fibers which are distributed in random directions and combined with each other mainly at intersections thereof by carbonized binder and at least one fiber reinforced plastic layer comprising reinforcing fibers and a matrix resin. The composite material can have a low density, high mechanical properties of strength, modulus of elasticity and rigidity.
摘要翻译： 具有层叠结构的轻质复合材料包括至少一个多孔纤维层，所述多孔纤维层由增强短纤维构成，所述短纤维以随机方向分布并且主要在其相交处通过碳化粘合剂彼此组合，并且至少一个纤维增强塑料层包括增强 纤维和基质树脂。 复合材料可以具有低密度，高强度的机械性能，弹性模量和刚度。
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10.发明申请公开(公告)号：US20140335090A1
公开(公告)日：2014-11-13
申请号：US14009026
申请日：2012-03-30
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , G01N33/57407 , G01N33/57446 , G01N2333/71 , G01N2800/52
摘要： Disclosed are a novel therapeutic agent for cancer such as esophageal squamous cell carcinoma, a method for predicting the prognosis of cancer, and a method for detecting, or predicting the prognosis of, cancer such as esophageal squamous cell carcinoma using a sample that can be collected less invasively. The therapeutic agent for cancer comprises as an effective component an antibody that undergoes antigen-antibody reaction with FGFRL1 to suppress the growth of cancer cells, or an antigen-binding fragment thereof. The method for predicting the prognosis of cancer comprises investigating the expression level of FGFRL1 in a cancer tissue separated from a living body, and, in this method, a high expression level of FGFRL1 indicates poor prognosis. The method for detecting cancer comprises measuring FGFRL1 or a fragment thereof extracted from a body tissue, or FGFRL1 or a fragment thereof in blood separated from a living body, and, in this method, a higher concentration of FGFRL1 or the fragment thereof contained therein than the concentration of FGFRL1 or the fragment thereof in the tissue or blood of a healthy individual indicates the presence of cancer.
摘要翻译： 公开了一种用于癌症的新型治疗剂，例如食管鳞状细胞癌，预测癌症预后的方法，以及使用可以收集的样品来检测或预测癌症如食管鳞状细胞癌的预后的方法 较少侵略 癌症治疗剂包括与FGFRL1进行抗原抗体反应以抑制癌细胞生长的抗体或其抗原结合片段作为有效成分。 用于预测癌症预后的方法包括研究从活体分离的癌组织中FGFRL1的表达水平，并且在该方法中，FGFRL1的高表达水平表示不良预后。 用于检测癌症的方法包括测量从活体分离的血液中从身体组织提取的FGFRL1或其片段或FGFRL1或其片段，并且在该方法中，FGFRL1或其片段含有的浓度高于 健康个体的组织或血液中的FGFRL1或其片段的浓度表示存在癌症。
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