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    Process for producing a slow release composite
    4.
    发明授权
    Process for producing a slow release composite 失效
    缓释复合材料的制备方法

    公开(公告)号：US4582719A

    公开(公告)日：1986-04-15

    申请号：US514026

    申请日：1983-07-15

    申请人： Isao Kaetsu ,  Masaharu Asano ,  Minoru Kumakura ,  Masaru Yoshida

    发明人： Isao Kaetsu ,  Masaharu Asano ,  Minoru Kumakura ,  Masaru Yoshida

    IPC分类号： A01N25/10 ,  A61K9/20 ,  A61K9/22 ,  A61K9/52 ,  B01J19/12 ,  B05D3/06

    CPC分类号： A01N25/10 ,  A61K9/2063

    摘要： A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.

    摘要翻译： 本文公开了一种用于生产包含其中的生理活性物质的缓释复合物的方法，其包括制备其中一种或多种生理活性物质与来自一种或多种蛋白质来源的蛋白质接触的系统，并将所述系统引入 在50℃至100℃的温度下直接与蒸汽接触以使蛋白质变性并制成相同的疏水性，从而制备其生理活性物质分散，固定和包封的缓释复合物。 还公开了用于生产缓释复合物的方法，其包括制备含有体液和/或等渗溶液的一种或多种亲水性可聚合单体，来自一种或多种蛋白质来源的蛋白质和一种或多种生理活性物质的混合物， 使混合物与蒸汽直接接触并用光或电离辐射照射，所述用蒸汽进行的处理在用光或电离辐射照射之前或同时进行。

    Process for producing a slow release composite
    6.
    发明授权
    Process for producing a slow release composite 失效
    缓释复合材料的制备方法

    公开(公告)号：US4483807A

    公开(公告)日：1984-11-20

    申请号：US340989

    申请日：1982-01-20

    申请人： Masaharu Asano ,  Masaru Yoshida ,  Isao Kaetsu

    发明人： Masaharu Asano ,  Masaru Yoshida ,  Isao Kaetsu

    IPC分类号： A01N25/10 ,  A61K9/20 ,  A61K9/26 ,  C08L89/00 ,  H05B6/64

    CPC分类号： C08L89/00 ,  A01N25/10 ,  A61K9/2045 ,  A61K9/2063 ,  Y10T428/24653

    摘要： A process is herein disclosed for producing a slow release composite comprising grinding and mixing mechanically in a frozen state one or more polypeptides, one or more proteins and one or more physiologically active substances shaping the blend into a desired form and compressing at a pressure of from 100 to 20,000 kg/cm.sup.2 to thereby produce a slow release composite having the physiologically active substances encapsulated therein.

    摘要翻译： 本文公开了一种用于生产缓释复合物的方法，其包括在冷冻状态下机械研磨和混合一种或多种多肽，一种或多种蛋白质和一种或多种将所述共混物成形为所需形式的生理活性物质，并以 100至20,000kg / cm2，从而制备其中包含生理活性物质的缓释复合物。

    Process for producing a multi-layered slow release composite
    8.
    发明授权
    Process for producing a multi-layered slow release composite 失效
    制备多层缓释复合材料的方法

    公开(公告)号：US4359483A

    公开(公告)日：1982-11-16

    申请号：US233135

    申请日：1981-02-10

    申请人： Isao Kaetsu ,  Masaru Yoshida

    发明人： Isao Kaetsu ,  Masaru Yoshida

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K9/70 ,  A01N1/02 ,  B05D3/00 ,  B05D3/06

    CPC分类号： A61K9/70 ,  A61K9/2027 ,  A61K9/209 ,  Y10T428/2998

    摘要： A process is herein disclosed for producing a multi-layered slow release composite comprising: a first step wherein one or more physiologically active substances is mixed with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof, and the mixture is given a predetermined shape and subjected to a physical treatment to form a slow release composite; a second step wherein a predetermined thickness of coating of one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of said slow release composite, which then is subjected to a physical treatment so that a layer wherein no physiologically active substance is encapsulated is formed on the surface of said slow release composite; a third step wherein a predetermined thickness of coating of a mixture of one or more physiologically active substances with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of the slow release composite having the layer provided in the second step wherein no physiologically active substance is encapsulated, said composite then is subjected to a physical treatment to form a layer wherein the physiologically active substance is encapsulated.

    摘要翻译： 本文公开了一种用于生产多层缓释复合材料的方法，其包括：第一步骤，其中将一种或多种生理活性物质与选自一种或多种过冷可聚合乙烯基单体，一种或多种天然或 合成的聚合物质及其混合物，并给出预定的形状并进行物理处理以形成缓释复合材料; 第二步骤，其中在所述缓释复合材料的表面上形成预定厚度的选自由一种或多种过冷可聚合乙烯基单体，一种或多种天然或合成聚合物质及其混合物组成的组的涂层，其中 然后进行物理处理，使得在所述缓释复合材料的表面上形成不包裹生理活性物质的层; 第三步骤，其中形成预定厚度的一种或多种生理活性物质与选自一种或多种过冷可聚合乙烯基单体，一种或多种天然或合成聚合物质及其混合物的组分的混合物的涂层 在其中没有包裹生理活性物质的第二步中提供的具有层的缓释复合物的表面上，然后将所述复合物进行物理处理以形成其中包封生理活性物质的层。

    Primer composition and a process for producing a coated product using the same
    9.
    发明授权
    Primer composition and a process for producing a coated product using the same 失效
    底漆组合物和使用其的涂布产品的制备方法

    公开(公告)号：US4311732A

    公开(公告)日：1982-01-19

    申请号：US45854

    申请日：1979-06-05

    申请人： Isao Kaetsu ,  Minoru Kumakura ,  Masaru Yoshida ,  Goro Shimaoka ,  Masanobu Urabe

    发明人： Isao Kaetsu ,  Minoru Kumakura ,  Masaru Yoshida ,  Goro Shimaoka ,  Masanobu Urabe

    IPC分类号： B05D7/02 ,  B32B27/00 ,  C08G59/00 ,  C08J7/04 ,  C08L63/00 ,  C09D163/00 ,  D21H13/26

    CPC分类号： C08J7/042 ,  C08J2369/00 ,  C08J2433/06 ,  C08J2483/04 ,  Y10T428/31507

    摘要： In accordance with this invention, there is provided a primer composition prepared by dissolving in an organic solvent at least one diepoxy compound selected from the group consisting of:(1) polyalkylene glycol diglycidyl ether of the formula; ##STR1## (2) poly(alkylene glycol) diglycidyl ether of the formula; ##STR2## and (3) diepoxide derived from a bisphenol of the formula; (wherein R.sub.1 is a linear or branched alkylene group having less than 8 carbon atoms; R.sub.2 is a linear or branched alkyl group having less than 4 carbon atoms, R.sub.3 is a linear or branched alkylene group having less than 8 carbon atoms, or a binding group selected from the class consisting of ##STR3## l, m and n are each an integer of from 0 to less than 10, the sum of l and m being more than 1).Also in accordance with the invention, there is provided a process for producing a coated product using such primer composition.

    摘要翻译： 根据本发明，提供了一种底漆组合物，其通过将有机溶剂中至少一种选自以下的二环氧化合物溶解于（1）下式的聚亚烷基二醇二缩水甘油醚： （2）下式的聚（亚烷基二醇）二缩水甘油醚; ＆lt; IMAGE＆gt; + TR＆lt; IMAGE＆gt;和（3）衍生自下式双酚的二环氧化物; （其中R 1为碳原子数少于8个的直链或支链亚烷基; R 2为碳原子数小于4的直链或支链烷基，R3为具有少于4个碳原子的直链或支链亚烷基 或者选自由以下组成的组的结合基团，其中，所述结构基团是由0和小于10的整数，1和m的和大于1）。 还根据本发明，提供了使用这种底漆组合物生产涂布产品的方法。