利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

33 条记录 (耗时 0.017 秒)

    Compositions and methods for inhibiting G2 cell cycle arrest and sensitizing cells to DNA damaging agents
    1.
    发明授权
    Compositions and methods for inhibiting G2 cell cycle arrest and sensitizing cells to DNA damaging agents 有权
    用于抑制G2细胞周期停滞和使细胞对DNA损伤剂敏感的组合物和方法

    公开(公告)号：US07851592B2

    公开(公告)日：2010-12-14

    申请号：US10967008

    申请日：2004-10-15

    申请人： Masashi Suganuma ,  Takumi Kawabe

    发明人： Masashi Suganuma ,  Takumi Kawabe

    IPC分类号： C07K14/435 ,  C07K14/47 ,  A61K38/00 ,  A61K48/00

    CPC分类号： C07K14/4738 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： The invention provides compositions and methods for inhibiting Chk1 and/or Chk2 kinases. Also provided are compositions and methods for inhibiting G2 cell arrest checkpoint, particularly in mammalian, e.g., human, cells. The compositions and methods of the invention are also used to treat disorders of cell growth, such as cancer. In particular, the invention provides methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA damaging agents and treatments. Also provided are methods for screening for compounds able to interact with, e.g., inhibit, enzymes involved in the G2 cell cycle arrest checkpoint, such as Chk1 and/or Chk2/Cds1 kinase.

    摘要翻译： 本发明提供了用于抑制Chk1和/或Chk2激酶的组合物和方法。 还提供了用于抑制G2细胞停滞检查点的组合物和方法，特别是在哺乳动物例如人的细胞中。 本发明的组合物和方法也用于治疗诸如癌症的细胞生长障碍。 特别地，本发明提供了选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗敏感的方法。 还提供了筛选能够与例如Chk1和/或Chk2 / Cds1激酶参与的G2细胞周期停滞检查点相关的化合物例如抑制化合物的方法。

    Injecting apparatus with check valve
    5.
    发明授权
    Injecting apparatus with check valve 失效
    带止回阀的注射装置

    公开(公告)号：US06533567B2

    公开(公告)日：2003-03-18

    申请号：US09881405

    申请日：2001-06-14

    申请人： Masashi Suganuma ,  Kazuki Hayashi ,  Takayoshi Shioiri

    发明人： Masashi Suganuma ,  Kazuki Hayashi ,  Takayoshi Shioiri

    IPC分类号： B29C4576

    CPC分类号： B29C45/52 ,  B29C45/76 ,  B29C2945/76093 ,  B29C2945/76096 ,  B29C2945/76187 ,  B29C2945/76367 ,  B29C2945/76665 ,  B29C2945/76692 ,  B29C2945/76846 ,  B29C2945/76943

    摘要： A screw injecting apparatus includes a check valve mounted on the tip end portion of a screw and adapted to be opened and closed in response to rotation of the screw, and a control for controlling operation of the screw such that in a metering phase of molding process, the screw rotates in one direction to feed a melt of molding material toward the nozzle while the check valve is in an open state, when a metered amount of melt is accumulated forward of the tip end portion, the screw moves backward by a predetermined distance to reduce a reaction from the melt accumulated around the tip end portion, thereafter, the screw rotates in the reverse direction to close the check valve and cause the screw to advance until the amount of forward movement of the screw becomes substantially equal to the predetermined distance of backward movement achieved previously.

    摘要翻译： 螺杆注射装置包括安装在螺钉的末端部分上并且响应于螺杆的旋转而被打开和关闭的止回阀，以及用于控制螺杆的操作的控制器，使得在成型过程的计量阶段 螺杆在一个方向上旋转，以便当止回阀处于打开状态时将成型材料的熔体供给喷嘴，当前端部分向前累积计量的熔体时，螺杆向后移动预定距离 以减少从前端部聚集的熔融物的反应，之后，螺杆向相反方向旋转，关闭止回阀，使螺杆前进，直到螺杆的向前运动量大致等于预定距离 以前实现的后向运动。

    Method for producing a composite metal product
    9.
    发明授权
    Method for producing a composite metal product 失效
    复合金属制品的制造方法

    公开(公告)号：US06860314B1

    公开(公告)日：2005-03-01

    申请号：US10645343

    申请日：2003-08-21

    申请人： Atsushi Koide ,  Kiyoto Takizawa ,  Yoshitoshi Yamagiwa ,  Masashi Suganuma ,  Mamoru Miyagawa

    发明人： Atsushi Koide ,  Kiyoto Takizawa ,  Yoshitoshi Yamagiwa ,  Masashi Suganuma ,  Mamoru Miyagawa

    IPC分类号： B22D17/00 ,  B22D17/20 ,  B22D27/08

    CPC分类号： B22D17/007 ,  B22D17/2061 ,  Y10S164/90

    摘要： A low melting point metal material is made to a thixotropic state in which liquid phases and solid phases coexists. In the thixotropic state of the low melting point metal material, a carbon nano material is kneaded with the low melting point metal material and forms a composite material. Thus obtained composite material is supplied to a metal molding machine and injected into a mold in a thixotropic state or a completely molten state of the metal so that the composite material fills the mold, thereby the composite material is molded to a composite metal product. With the above process, it is possible to injection mold the composite metal product to which the characteristics of the carbon nano material are applied.

    摘要翻译： 将低熔点金属材料制成触变状态，其中液相和固相共存。 在低熔点金属材料的触变状态下，碳纳米材料与低熔点金属材料混合并形成复合材料。 将这样得到的复合材料供给到金属成型机中，并注入金属的触变状态或完全熔融状态的模具中，使得复合材料填充模具，从而将复合材料成型为复合金属制品。 通过上述方法，可以对应用碳纳米材料的特性的复合金属制品进行注射成型。

    Fuzzy inference thermocontrol method for an injection molding machine
    10.
    发明授权
    Fuzzy inference thermocontrol method for an injection molding machine 失效
    用于注射成型机的FUZZY INTERTHER THERMOCONTROL方法

    公开(公告)号：US5149472A

    公开(公告)日：1992-09-22

    申请号：US745331

    申请日：1991-08-15

    申请人： Masashi Suganuma

    发明人： Masashi Suganuma

    IPC分类号： B29C45/62 ,  B29C45/72 ,  B29C45/74 ,  B29C45/78

    CPC分类号： B29C45/78 ,  Y10S706/90

    摘要： To eliminate a temperature overshoot or an undershoot during thermocontrol of thermocontrolled components, e.g. an injection cylinder, with resepct to an object temperature in each operating status of the injection molding machine, the Fuzzy Control theory is used for controlling the injection molding machine. By using the Fuzzy Control system, the object temperature of the thermocontrolled components can be attained with practically eliminated overshoot and undershoot.

    摘要翻译： 为了消除热控制部件的热控制期间的温度过冲或下冲，例如。 注射缸，在注射成型机的每个运行状态下都能达到目标温度，模糊控制理论用于控制注塑机。 通过使用模糊控制系统，可以通过实际消除的过冲和下冲来获得热控制部件的物体温度。