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    Compositions and methods for inhibiting G2 cell cycle arrest and sensitizing cells to DNA damaging agents
    3.
    发明授权
    Compositions and methods for inhibiting G2 cell cycle arrest and sensitizing cells to DNA damaging agents 有权
    用于抑制G2细胞周期停滞和使细胞对DNA损伤剂敏感的组合物和方法

    公开(公告)号：US07851592B2

    公开(公告)日：2010-12-14

    申请号：US10967008

    申请日：2004-10-15

    申请人： Masashi Suganuma ,  Takumi Kawabe

    发明人： Masashi Suganuma ,  Takumi Kawabe

    IPC分类号： C07K14/435 ,  C07K14/47 ,  A61K38/00 ,  A61K48/00

    CPC分类号： C07K14/4738 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： The invention provides compositions and methods for inhibiting Chk1 and/or Chk2 kinases. Also provided are compositions and methods for inhibiting G2 cell arrest checkpoint, particularly in mammalian, e.g., human, cells. The compositions and methods of the invention are also used to treat disorders of cell growth, such as cancer. In particular, the invention provides methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA damaging agents and treatments. Also provided are methods for screening for compounds able to interact with, e.g., inhibit, enzymes involved in the G2 cell cycle arrest checkpoint, such as Chk1 and/or Chk2/Cds1 kinase.

    摘要翻译： 本发明提供了用于抑制Chk1和/或Chk2激酶的组合物和方法。 还提供了用于抑制G2细胞停滞检查点的组合物和方法，特别是在哺乳动物例如人的细胞中。 本发明的组合物和方法也用于治疗诸如癌症的细胞生长障碍。 特别地，本发明提供了选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗敏感的方法。 还提供了筛选能够与例如Chk1和/或Chk2 / Cds1激酶参与的G2细胞周期停滞检查点相关的化合物例如抑制化合物的方法。

    Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments
    4.
    发明授权
    Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments 失效
    消除DNA损伤诱导的细胞周期G2检查点和/或增加DNA损伤治疗的抗癌活性的化合物

    公开(公告)号：US07030111B2

    公开(公告)日：2006-04-18

    申请号：US10457029

    申请日：2003-06-06

    申请人： Takumi Kawabe ,  Hidetaka Kobayashi

    发明人： Takumi Kawabe ,  Hidetaka Kobayashi

    IPC分类号： A61K31/5375 ,  A61K31/495 ,  C07D265/30 ,  C07D241/04

    CPC分类号： C07C327/26 ,  C07C69/76 ,  C07C327/36 ,  C07D213/65 ,  G01N33/5011

    摘要： The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

    摘要翻译： 本发明提供抑制哺乳动物细胞（包括人细胞）中的细胞周期G2检查点，特别是DNA损伤诱导的G2检查点的组合物和方法。 具体地，本发明提供了通过废除细胞周期G2检查点来使细胞对DNA损伤剂敏感的组合物和方法。 本发明的化合物用于治疗增殖性疾病如癌症。 本发明提供了选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗敏感的组合物和方法。

    Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments
    5.
    发明授权
    Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments 失效
    消除DNA损伤的化合物诱导细胞周期G2检查点和/或增加DNA损伤治疗的抗癌活性

    公开(公告)号：US07652042B2

    公开(公告)日：2010-01-26

    申请号：US12131564

    申请日：2008-06-02

    申请人： Takumi Kawabe ,  Hidetaka Kobayashi

    发明人： Takumi Kawabe ,  Hidetaka Kobayashi

    IPC分类号： A61K31/44 ,  A61K31/235 ,  A61K31/095

    CPC分类号： C07C327/26 ,  C07C69/76 ,  C07C327/36 ,  C07D213/65 ,  G01N33/5011

    摘要： The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

    摘要翻译： 本发明提供抑制哺乳动物细胞（包括人细胞）中的细胞周期G2检查点，特别是DNA损伤诱导的G2检查点的组合物和方法。 具体地，本发明提供了通过废除细胞周期G2检查点来使细胞对DNA损伤剂敏感的组合物和方法。 本发明的化合物用于治疗增殖性疾病如癌症。 本发明提供了选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗敏感的组合物和方法。

    PEPTIDES AND PEPTIDOMIMETICS HAVING IMMUNE-MODULATING, ANTI-INFLAMMATORY, AND ANTI-VIRAL ACTIVITY
    6.
    发明申请
    PEPTIDES AND PEPTIDOMIMETICS HAVING IMMUNE-MODULATING, ANTI-INFLAMMATORY, AND ANTI-VIRAL ACTIVITY 审中-公开
    具有免疫调节，抗炎和抗病毒活性的肽和肽

    公开(公告)号：US20090192090A1

    公开(公告)日：2009-07-30

    申请号：US12347683

    申请日：2008-12-31

    申请人： Takumi Kawabe ,  Hidetaka Kobayashi

    发明人： Takumi Kawabe ,  Hidetaka Kobayashi

    IPC分类号： A61K38/10 ,  A61K38/08

    CPC分类号： G01N33/5047 ,  A61K38/10 ,  C07K1/1077 ,  C07K14/4705 ,  G01N33/5008 ,  G01N2800/52

    摘要： The invention provides compounds having immune-modulating and/or anti-inflammatory and/or anti-viral activity, wherein compounds of the invention include peptides and peptidomimetics. The invention further provides methods of using immune-modulating and/or anti-inflammatory and/or anti-viral compounds of the invention. In particular, the invention provides methods for treating a disease related to an immune disorder or inflammation or viral infection by administering an amount of a G2-checkpoint-abrogating peptide or peptidomimetic sufficient to inhibit the disease.

    摘要翻译： 本发明提供具有免疫调节和/或抗炎和/或抗病毒活性的化合物，其中本发明化合物包括肽和肽模拟物。 本发明还提供使用本发明的免疫调节和/或抗炎和/或抗病毒化合物的方法。 特别地，本发明提供了通过给予一定数量的足以抑制该疾病的消除G2检查点的肽或肽模拟物来治疗与免疫疾病或炎症或病毒感染有关的疾病的方法。

    Sensitivity test to predict efficacy of anti-cancer therapies
    8.
    发明申请
    Sensitivity test to predict efficacy of anti-cancer therapies 有权
    敏感性检测预测抗癌疗法的疗效

    公开(公告)号：US20060014157A1

    公开(公告)日：2006-01-19

    申请号：US10913711

    申请日：2004-08-06

    申请人： Takumi Kawabe ,  Hidetaka Kobayashi

    发明人： Takumi Kawabe ,  Hidetaka Kobayashi

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/5011 ,  A61K31/4745 ,  A61K33/24 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/142 ,  G01N33/502 ,  G01N2800/52 ,  A61K2300/00

    摘要： The present disclosure provides methods for determining the sensitivity of cancerous cells to various anti-cancer therapies and predicting the efficacy of these therapies. Specifically, the present disclosure provides methods for predicting the efficacy of one or more candidate anti-cancer therapies in a patient, based on determining the sensitivity of the patient's cancerous cells after exposure to candidate anti-cancer therapies in vitro. The disclosure further provides methods for predicting the efficacy of candidate anti-cancer therapies by using an in vitro sensitivity test of the patient's cancerous cells and a surrogate in vivo efficacy test of the patient's cancerous cells grafted into a surrogate host. The disclosure further provides methods for selecting the most efficacious anti-cancer therapy(s) for a patient, thereby avoiding ineffective or unnecessary treatments.

    摘要翻译： 本公开提供了确定癌细胞对各种抗癌疗法的敏感性并预测这些疗法的功效的方法。 具体地，本公开提供了基于在体外暴露于候选抗癌疗法之后确定患者癌细胞的敏感性来预测患者中一种或多种候选抗癌疗法的功效的方法。 本公开进一步提供了通过使用患者癌细胞的体外敏感性试验和接种到替代宿主中的患者的癌细胞的替代体内功效试验来预测候选抗癌疗法的功效的方法。 本公开还提供了选择用于患者的最有效的抗癌疗法的方法，从而避免无效或不必要的治疗。

    Interlocking structure, mounting member, and airbag device
    9.
    发明授权
    Interlocking structure, mounting member, and airbag device 有权
    联锁结构，安装构件和安全气囊装置

    公开(公告)号：US09457757B2

    公开(公告)日：2016-10-04

    申请号：US14427057

    申请日：2013-09-09

    申请人： Takumi Kawabe ,  Shuhei Fujiwara ,  Keisuke Onohara ,  Kouhei Nagashima

    发明人： Takumi Kawabe ,  Shuhei Fujiwara ,  Keisuke Onohara ,  Kouhei Nagashima

    IPC分类号： B60R21/215 ,  B60R13/00 ,  B60R21/203

    CPC分类号： B60R21/215 ,  B60R13/005 ,  B60R21/203 ,  B60R2021/21543

    摘要： A mounting member to be mounted to an obverse side of a cover part arranged at a central portion of a steering wheel includes corner parts 31a, 31b, 31c, and 31d having hook parts 36-3, 36-4, 36-5, and 36-6 protruding from their reverse sides, the hook parts 36-3, 36-4, 36-5, and 36-6 being capable of interlocking with holes formed at the cover part. The hook parts 36-3, 36-4, 36-5, and 36-6 are arranged at narrow parts 37a and 37b between a contour 33 of the mounting member 30 and openings 35a and 35b formed along the contour 33.

    摘要翻译： 安装在方向盘中央部的盖部的正面侧的安装构件包括具有钩部36-3,36-4,36-5的角部31a，31b，31c，31d， 36-6从其相反侧突出，钩部分36-3,36-4,36-5和36-6能够与形成在盖部分处的孔互锁。 钩部36-3,36-4,36-5,36-6配置在安装部件30的轮廓33与沿轮廓33形成的开口部35a，35b之间的狭窄部37a，37b。

    Compounds with anti-cancer activity
    10.
    发明授权
    Compounds with anti-cancer activity 有权
    化合物具有抗癌活性

    公开(公告)号：US08415357B2

    公开(公告)日：2013-04-09

    申请号：US12950297

    申请日：2010-11-19

    申请人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

    发明人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

    IPC分类号： A61K31/497 ,  A61K31/44 ,  A61K31/47

    CPC分类号： A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  C07D207/452 ,  C07D207/50 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

    摘要： Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

    摘要翻译： 提供了新型取代的唑类二恶英，其杀死细胞，抑制细胞增殖，抑制细胞生长，消除细胞周期G2检查点和/或引起适应G2细胞周期停滞。 提供了制备和使用本发明化合物的方法。 本发明提供取代的唑类二恶英以治疗细胞增殖障碍。 本发明包括使用取代的唑类二聚体来选择性地杀死或抑制癌细胞而无需额外的抗癌治疗。 本发明包括使用细胞周期G2-检查点 - 取代的取代唑类二恶英来选择性地使癌细胞对DNA损伤试剂，治疗和/或其它类型的抗癌试剂敏感。