公开(公告)号：US5817238A

公开(公告)日：1998-10-06

申请号：US816519

申请日：1997-03-13

申请人： Kaoru Makino ,  Kazuhiro Kawai ,  Masatake Tanimura ,  Masao Tamura

发明人： Kaoru Makino ,  Kazuhiro Kawai ,  Masatake Tanimura ,  Masao Tamura

IPC分类号： C07D307/62 ,  B01D15/08 ,  B01J39/26 ,  C07B63/00

CPC分类号： B01J39/26

摘要： A process for producing purified L-ascorbic acid, which comprises subjecting an aqueous solution of crude L-ascorbic acid to column chromatography using a strongly acidic cation exchange resin; and a method of purifying L-ascorbic acid, which comprises subjecting an aqueous solution of crude L-ascorbic acid to column chromatography using a strongly acidic cation exchange resin.

摘要翻译： 一种生产纯化的L-抗坏血酸的方法，其包括使用强酸性阳离子交换树脂对粗L-抗坏血酸水溶液进行柱层析; 以及L-抗坏血酸的纯化方法，其特征在于，使用强酸性阳离子交换树脂对粗L-抗坏血酸水溶液进行柱色谱分离。

公开(公告)号：US5064539A

公开(公告)日：1991-11-12

申请号：US608591

申请日：1990-10-31

申请人： Masatake Tanimura ,  Masao Tamura ,  Takashi Teshima

发明人： Masatake Tanimura ,  Masao Tamura ,  Takashi Teshima

IPC分类号： G01N30/44 ,  B01D15/08 ,  G01N30/46 ,  G01N30/80

CPC分类号： B01D15/1828

摘要： In a method using a chromatographic separation apparatus consisting of plurality of unit packed beds each having a supply inlet/extraction outlet, wherein the apparatus is effectively divided into four zones; an adsorption zone, a refining zone, a desorption zone, and a concentration zone. A supply and extraction step is performed in which all of the fluid flowing out of the adsorption zone is extracted through the nonadsorbate fluid extraction outlet, and then a recycle step, in which no fluid is supplied to or extracted from the bed, is performed to move the concentration distributions in the bed to a desired position. As a result, the method requires fewer unit beds, and enables extraction of components of higher purity.

公开(公告)号：US5556546A

公开(公告)日：1996-09-17

申请号：US362927

申请日：1994-12-23

申请人： Masatake Tanimura ,  Masao Tamura

发明人： Masatake Tanimura ,  Masao Tamura

IPC分类号： B01D15/18 ,  C13B20/14 ,  C13B35/06 ,  C13K1/08 ,  C13K7/00 ,  B01D15/08

CPC分类号： C13B35/06 ,  B01D15/1828 ,  C13B20/144 ,  C13K1/08 ,  C13K7/00 ,  B01D2215/023

摘要： The method of chromatographic separation comprises: a feed-withdrawal step in which, with liquid flow being permitted from the first to the third unit beds in the simulated moving bed, an eluant is fed into the first unit bed and the feed stock is fed into the third unit bed while, at the same time, part of the effluent from the first unit bed is withdrawn from the system as a fraction rich in component B and the effluent from the third unit bed is withdrawn from the system as a fraction rich in component C; a circulation stage in which, with liquid circulation being permitted through the simulated moving bed, the liquid in the simulated moving bed is moved downstream without liquid feed to or withdrawal from the simulated moving bed; and a withdrawal stage in which, with liquid flow being permitted from the second to the first unit beds, the eluant is fed to the second unit bed and the effluent from the first unit bed is withdrawn from the system as a fraction rich in component A; wherein, after the above three stages are performed, the same stages are repeated except that feed stock and eluant are fed to, and effluents are withdrawn from unit beds which exist immediately downstream of the respective corresponding unit beds.

摘要翻译： 色谱分离方法包括：进料提取步骤，其中，在模拟移动床中从第一至第三单元床允许液体流动的同时，将洗脱液送入第一单元床，并将原料进料至 第三单元床，同时来自第一单元床的部分流出物作为富含组分B的馏分从系统中排出，并且来自第三单元床的流出物作为富含馏分的馏分从系统中排出 组分C; 循环阶段，其中通过模拟移动床允许液体循环，模拟移动床中的液体向下游移动，而不进行液体馈送或从模拟移动床退出; 以及取出阶段，其中从第二单元床到第一单元床允许液体流动，将洗脱液进料到第二单元床，并且来自第一单元床的流出物作为富含组分A的馏分从系统中排出 ; 其中，在执行上述三个阶段之后，重复进行相同的步骤，除了将原料和洗脱剂进料到，并且从相应的相应单元床的紧下游存在的单元床中排出流出物。

公开(公告)号：US4970002A

公开(公告)日：1990-11-13

申请号：US336516

申请日：1989-04-11

申请人： Masao Ando ,  Masatake Tanimura ,  Masao Tamura

发明人： Masao Ando ,  Masatake Tanimura ,  Masao Tamura

IPC分类号： G01N30/44 ,  B01D15/00 ,  B01D15/08 ,  B01D15/18 ,  G01N30/46

CPC分类号： B01D15/1814

摘要： A chromatographic separation process employing fewer beds packed with an adsorbent, while enabling separation of feedstock fluid, containing a plurality of components which have different degrees of affinity for the adsorbent, into constituent fractions which are withdrawn separately. According to at least one preferred embodiment, a step of supplying feedstock fluid to the simplified separation apparatus is preceded and followed by a step of circulating the fluid through the apparatus, a cycle of supply-desorbing-circulation being carried out repeatedly.

公开(公告)号：US06488858B2

公开(公告)日：2002-12-03

申请号：US09801743

申请日：2001-03-09

申请人： Masatake Tanimura ,  Toshihiro Iwamoto

发明人： Masatake Tanimura ,  Toshihiro Iwamoto

IPC分类号： B01D1508

CPC分类号： B01J39/26 ,  B01D15/163 ,  B01D15/1814 ,  B01D15/1871 ,  B01D15/362

摘要： A chromatographic process of a type wherein a feedstock fluid containing a plurality of components is supplied into a circulative chromatographic separation system, the process comprising the steps of (i) supplying the feedstock fluid and withdrawing a fraction enriched in a component, (ii) supplying a desorbent fluid and withdrawing a fraction enriched in another component, and (iii) circulating the fluid through the bed without supplying or withdrawing any fluid thereby making a mixed zone comprising a plurality of components move, a cycle including steps (i), (ii) and (iii) being repeated while controlling the discharged pressure of a pump delivering the feedstock fluid, the desorbent fluid, and the circulating fluid constant.

摘要翻译： 一种类型的色谱法，其中含有多种成分的原料流体被供应到循环色谱分离系统中，该方法包括以下步骤：（i）供应原料流体并抽出富含组分的级分，（ii）供应 一种解吸流体，并且抽出一种富含另一种组分的级分，和（iii）使流体循环通过床而不供应或排出任何流体，从而使包括多个组分的混合区域移动，循环包括步骤（i），（ii ）和（iii）在控制输送原料流体，解吸流体和循环流体的泵的排出压力恒定的同时被重复。

公开(公告)号：US4599115A

公开(公告)日：1986-07-08

申请号：US634006

申请日：1984-07-24

申请人： Masao Ando ,  Masatake Tanimura

发明人： Masao Ando ,  Masatake Tanimura

IPC分类号： B01D15/00 ,  B01D15/08 ,  B01D15/18 ,  B01D53/04 ,  C13K3/00 ,  C13K13/00 ,  G01N30/28 ,  G01N30/46 ,  C13J1/06 ,  C13J1/08

CPC分类号： B01D53/08 ,  B01D15/1828 ,  B01D53/04 ,  B01D53/0454 ,  C13K13/007 ,  C13K3/00 ,  B01D2215/023 ,  B01D2215/024 ,  B01D2256/24 ,  B01D2259/404 ,  B01D2259/41 ,  B01D53/0446

摘要： A method is disclosed for controlling a simulated moving bed system of a type including at least four series-arranged beds each packed with a solid adsorbent, with the downstream end of each bed and the upstream end of the next succeeding bed being connected by conduits to form an endless loop, and in which a fluid is caused to circulate through the beds in one direction, a feed stock and a desorbent are introduced into the system while a raffinate and a sorbate are withdrawn from the system, and the positions of introduction and withdrawal of the four kinds of fluid are periodically shifted in the direction of the circulating fluid flow. In accordance with the invention, two or more circulating pumps, provided with variable speed controllers and pressure detectors for detecting the suction pressure of each of the circulating pumps, are disposed between two beds. The flow rates of three of the four fluids introduced into or withdrawn from the system are adjusted to predetermined values, and the flow rate of the other fluid is controlled in such a manner that the suction pressure of one of the circulating pumps or the average of the suction pressures of two or more of the circulating pumps is held constant, and a rotational speed of each of the circulating pumps is controlled independently so as to control the flow rate of the circulating fluid and to maintain the suction pressure of each circulating pump at a low level.

摘要翻译： 公开了一种用于控制一种类型的模拟移动床系统的方法，其包括每个填充有固体吸附剂的至少四个串联布置的床，每个床的下游端和下一个后续床的上游端通过导管连接到 形成无限循环，并且使流体在一个方向上循环通过床，将原料和解吸剂引入系统中，同时从系统中抽出萃余液和吸附物，并且引入和 四种流体的排出周期性地沿循环流体的流动方向移动。 根据本发明，设置有两个或更多个循环泵，其设置有用于检测每个循环泵的吸入压力的变速控制器和压力检测器，两个床之间。 将引入或取出的四种流体中的三种流体的流量调节到预定值，并且以这样一种方式控制其它流体的流量，使得一种循环泵的吸入压力或平均值 循环泵的两个或更多个的吸入压力保持恒定，并且独立地控制每个循环泵的转速，以便控制循环流体的流量并将每个循环泵的吸入压力保持在 低水平