Method of chromatographic separation
    1.
    发明授权
    Method of chromatographic separation 失效
    色谱分离方法

    公开(公告)号:US5064539A

    公开(公告)日:1991-11-12

    申请号:US608591

    申请日:1990-10-31

    CPC分类号: B01D15/1828

    摘要: In a method using a chromatographic separation apparatus consisting of plurality of unit packed beds each having a supply inlet/extraction outlet, wherein the apparatus is effectively divided into four zones; an adsorption zone, a refining zone, a desorption zone, and a concentration zone. A supply and extraction step is performed in which all of the fluid flowing out of the adsorption zone is extracted through the nonadsorbate fluid extraction outlet, and then a recycle step, in which no fluid is supplied to or extracted from the bed, is performed to move the concentration distributions in the bed to a desired position. As a result, the method requires fewer unit beds, and enables extraction of components of higher purity.

    Method of separation into three components using a simulated moving bed
    2.
    发明授权
    Method of separation into three components using a simulated moving bed 失效
    使用模拟移动床分离成三个组分的方法

    公开(公告)号:US5556546A

    公开(公告)日:1996-09-17

    申请号:US362927

    申请日:1994-12-23

    摘要: The method of chromatographic separation comprises: a feed-withdrawal step in which, with liquid flow being permitted from the first to the third unit beds in the simulated moving bed, an eluant is fed into the first unit bed and the feed stock is fed into the third unit bed while, at the same time, part of the effluent from the first unit bed is withdrawn from the system as a fraction rich in component B and the effluent from the third unit bed is withdrawn from the system as a fraction rich in component C; a circulation stage in which, with liquid circulation being permitted through the simulated moving bed, the liquid in the simulated moving bed is moved downstream without liquid feed to or withdrawal from the simulated moving bed; and a withdrawal stage in which, with liquid flow being permitted from the second to the first unit beds, the eluant is fed to the second unit bed and the effluent from the first unit bed is withdrawn from the system as a fraction rich in component A; wherein, after the above three stages are performed, the same stages are repeated except that feed stock and eluant are fed to, and effluents are withdrawn from unit beds which exist immediately downstream of the respective corresponding unit beds.

    摘要翻译: 色谱分离方法包括:进料提取步骤,其中,在模拟移动床中从第一至第三单元床允许液体流动的同时,将洗脱液送入第一单元床,并将原料进料至 第三单元床,同时来自第一单元床的部分流出物作为富含组分B的馏分从系统中排出,并且来自第三单元床的流出物作为富含馏分的馏分从系统中排出 组分C; 循环阶段,其中通过模拟移动床允许液体循环,模拟移动床中的液体向下游移动,而不进行液体馈送或从模拟移动床退出; 以及取出阶段,其中从第二单元床到第一单元床允许液体流动,将洗脱液进料到第二单元床,并且来自第一单元床的流出物作为富含组分A的馏分从系统中排出 ; 其中,在执行上述三个阶段之后,重复进行相同的步骤,除了将原料和洗脱剂进料到,并且从相应的相应单元床的紧下游存在的单元床中排出流出物。

    Method of chromatographic separation
    3.
    发明授权
    Method of chromatographic separation 失效
    色谱分离方法

    公开(公告)号:US4970002A

    公开(公告)日:1990-11-13

    申请号:US336516

    申请日:1989-04-11

    CPC分类号: B01D15/1814

    摘要: A chromatographic separation process employing fewer beds packed with an adsorbent, while enabling separation of feedstock fluid, containing a plurality of components which have different degrees of affinity for the adsorbent, into constituent fractions which are withdrawn separately. According to at least one preferred embodiment, a step of supplying feedstock fluid to the simplified separation apparatus is preceded and followed by a step of circulating the fluid through the apparatus, a cycle of supply-desorbing-circulation being carried out repeatedly.

    Process for producing purified L-ascorbic acid
    4.
    发明授权
    Process for producing purified L-ascorbic acid 失效
    生产纯化的L-抗坏血酸的方法

    公开(公告)号:US5817238A

    公开(公告)日:1998-10-06

    申请号:US816519

    申请日:1997-03-13

    CPC分类号: B01J39/26

    摘要: A process for producing purified L-ascorbic acid, which comprises subjecting an aqueous solution of crude L-ascorbic acid to column chromatography using a strongly acidic cation exchange resin; and a method of purifying L-ascorbic acid, which comprises subjecting an aqueous solution of crude L-ascorbic acid to column chromatography using a strongly acidic cation exchange resin.

    摘要翻译: 一种生产纯化的L-抗坏血酸的方法,其包括使用强酸性阳离子交换树脂对粗L-抗坏血酸水溶液进行柱层析; 以及L-抗坏血酸的纯化方法,其特征在于,使用强酸性阳离子交换树脂对粗L-抗坏血酸水溶液进行柱色谱分离。