公开(公告)号：US20230395409A1

公开(公告)日：2023-12-07

申请号：US18248474

申请日：2021-11-12

Applicant: Massachusetts Institute of Technology

Inventor： David L. Trumper ,  Brij Mohan Bhushan

IPC: H01L21/67 ,  H01L21/68 ,  H01L21/683 ,  B65G47/92 ,  G03F7/00

CPC classification number: H01L21/67259 ,  H01L21/68 ,  H01L21/6833 ,  B65G47/92 ,  G03F7/70708 ,  G03F7/70741

Abstract: An electrostatic chuck includes electrodes to clamp a workpiece, electrodes to electrostatically levitate and position the workpiece, and sensors to detect position and orientation of the workpiece. Lateral motion of the workpiece relative to the electrostatic chuck can be damped prior to clamping.

公开(公告)号：US11749437B2

公开(公告)日：2023-09-05

申请号：US16400840

申请日：2019-05-01

Applicant: Massachusetts Institute of Technology

Inventor： Brij Mohan Bhushan ,  Daniel R. Rathbone ,  David L. Trumper ,  Minkyun Noh ,  Jun Young Yoon

IPC: H01F7/14 ,  B01L3/00 ,  B01L9/00 ,  C12M3/00 ,  C12M3/06 ,  C12M1/00 ,  F04B43/04 ,  F04B43/14

CPC classification number: H01F7/14 ,  B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502753 ,  B01L9/527 ,  C12M21/08 ,  C12M23/16 ,  C12M29/00 ,  F04B43/043 ,  F04B43/14 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0415

Abstract: On-platform pumps provide greater flexibility and design freedom and are a key feature of organs-on-chip platforms. On-platform electromagnetic (EM) pumps have been developed for use with the organ-on-chip platforms. The EM pump uses electrical energy, which may be supplied by a battery, making the pump portable. The EM pump uses an EM actuator having a low energy consumption. The actuator's low energy consumption is achieved by a latching design which requires only a short pulse of energy to switch its state and where springs store some of the actuator kinetic energy, which is then recovered in the reverse stroke. This further reduces the energy consumption of the actuator. Also provided are injection-molded, single-use platforms with onboard diaphragm micro-pumps and various valve and pump geometries. The EM actuators easily integrate with these platforms, demonstrating pumping at a constant flowrate, no measurable temperature rise, and valve sealing against varying back-pressure.

公开(公告)号：US11732229B2

公开(公告)日：2023-08-22

申请号：US17100542

申请日：2020-11-20

Applicant: Massachusetts Institute of Technology

Inventor： Linda Griffith ,  David Trumper ,  Collin Edington ,  Gaurav Rohatgi ,  Duncan Freake ,  Luis Soenksen ,  Brij Mohan Bhushan

IPC: C12M1/32 ,  F04B23/04 ,  F04B43/12 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  F04B43/04 ,  F04B23/06 ,  F04B19/00

CPC classification number: C12M23/12 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502738 ,  C12M25/14 ,  C12M29/10 ,  F04B19/006 ,  F04B23/04 ,  F04B23/06 ,  F04B43/043 ,  F04B43/12 ,  B01L2200/0621 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/086

Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.

公开(公告)号：US20210139829A1

公开(公告)日：2021-05-13

申请号：US17100542

申请日：2020-11-20

Applicant: Massachusetts Institute of Technology

Inventor： Linda Griffith ,  David Trumper ,  Collin Edington ,  Gaurav Rohatgi ,  Duncan Freake ,  Luis Soenksen ,  Brij Mohan Bhushan

IPC: C12M1/32 ,  F04B23/04 ,  F04B43/12 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  F04B43/04 ,  F04B23/06 ,  F04B19/00

Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.

公开(公告)号：US20190338230A1

公开(公告)日：2019-11-07

申请号：US16400840

申请日：2019-05-01

Applicant: Massachusetts Institute of Technology

Inventor： Brij Mohan Bhushan ,  Daniel R. Rathbone ,  David L. Trumper ,  Minkyun Noh ,  Jun Young Yoon

IPC: C12M3/00 ,  B01L3/00 ,  B01L9/00 ,  C12M3/06 ,  C12M1/00 ,  F04B43/04

Abstract: On-platform pumps provide greater flexibility and design freedom and are a key feature of organs-on-chip platforms. On-platform electromagnetic (EM) pumps have been developed for use with the organ-on-chip platforms. The EM pump uses electrical energy, which may be supplied by a battery, making the pump portable. The EM pump uses an EM actuator having a low energy consumption. The actuator's low energy consumption is achieved by a latching design which requires only a short pulse of energy to switch its state and where springs store some of the actuator kinetic energy, which is then recovered in the reverse stroke. This further reduces the energy consumption of the actuator. Also provided are injection-molded, single-use platforms with onboard diaphragm micro-pumps and various valve and pump geometries. The EM actuators easily integrate with these platforms, demonstrating pumping at a constant flowrate, no measurable temperature rise, and valve sealing against varying back-pressure.