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公开(公告)号：US20180272346A1
公开(公告)日：2018-09-27
申请号：US15926900
申请日：2018-03-20
Applicant: Massachusetts Institute of Technology
Inventor： Linda G. Griffith , David Trumper , Collin Edington , Gaurav Rohatgi , Duncan Freake , Luis Soenksen , Timothy Kassis , Mohan Brij Bhushan
CPC classification number: B01L3/502715 , B01J2219/00182 , B01J2219/00306 , B01J2219/00355 , B01J2219/00479 , B01J2219/00889 , B01J2219/00952 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2300/0829 , B01L2300/0887 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , C12M23/04 , C12M23/16 , C12M23/42 , F04B19/006 , F04B23/06 , F04B43/043 , F04B43/12 , G01F23/263
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks with microbiome for an extended period of time of at least weeks and months. The platform has one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs together with microbiome in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the bioreactors is also provided.
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公开(公告)号：US20210139829A1
公开(公告)日：2021-05-13
申请号：US17100542
申请日：2020-11-20
Applicant: Massachusetts Institute of Technology
Inventor： Linda Griffith , David Trumper , Collin Edington , Gaurav Rohatgi , Duncan Freake , Luis Soenksen , Brij Mohan Bhushan
IPC: C12M1/32 , F04B23/04 , F04B43/12 , B01L3/00 , C12M1/00 , C12M1/12 , F04B43/04 , F04B23/06 , F04B19/00
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.
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3.发明申请公开(公告)号：US20170227525A1
公开(公告)日：2017-08-10
申请号：US15425858
申请日：2017-02-06
Applicant: Massachusetts Institute of Technology
Inventor： Linda Griffith , David Trumper , Collin Edington , Gaurav Rohatgi , Duncan Freake , Luis Soenksen , Mohan Brij Bhushan
CPC classification number: C12M23/12 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2300/0829 , B01L2300/0887 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , C12M25/14 , C12M29/10 , F04B19/006 , F04B23/04 , F04B23/06 , F04B43/043 , F04B43/12
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.
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公开(公告)号：US11732229B2
公开(公告)日：2023-08-22
申请号：US17100542
申请日：2020-11-20
Applicant: Massachusetts Institute of Technology
Inventor： Linda Griffith , David Trumper , Collin Edington , Gaurav Rohatgi , Duncan Freake , Luis Soenksen , Brij Mohan Bhushan
IPC: C12M1/32 , F04B23/04 , F04B43/12 , B01L3/00 , C12M1/00 , C12M1/12 , F04B43/04 , F04B23/06 , F04B19/00
CPC classification number: C12M23/12 , B01L3/50273 , B01L3/502715 , B01L3/502738 , C12M25/14 , C12M29/10 , F04B19/006 , F04B23/04 , F04B23/06 , F04B43/043 , F04B43/12 , B01L2200/0621 , B01L2300/0829 , B01L2300/0887 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0655 , B01L2400/086
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.
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