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公开(公告)号：US20180360952A9
公开(公告)日：2018-12-20
申请号：US15673126
申请日：2017-08-09
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K39/385 , A61K47/69 , A61K9/127 , A61K38/20 , A61K39/21
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
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公开(公告)号：US09750803B2
公开(公告)日：2017-09-05
申请号：US15230736
申请日：2016-08-08
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K39/385 , A61K9/127 , A61K39/015 , A61K39/39 , A61K39/21 , A61K47/48 , C07K14/005 , C12N15/88 , A61K39/12 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/45 , A61K39/395 , A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
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公开(公告)号：US09339462B2
公开(公告)日：2016-05-17
申请号：US14581004
申请日：2014-12-23
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K9/127 , A61K38/20 , A61K45/06 , A61K39/21 , A61K39/39 , C07K14/005 , A61K39/12 , A61K39/35 , C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
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公开(公告)号：US20140271827A1
公开(公告)日：2014-09-18
申请号：US14265924
申请日：2014-04-30
发明人： Darrell J. Irvine , Jaehyun Moon
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
摘要翻译： 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡可以包含预防性，治疗和/或诊断剂。
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公开(公告)号：US20140017170A1
公开(公告)日：2014-01-16
申请号：US13910937
申请日：2013-06-05
IPC分类号： A61K9/127 , A61K47/46 , A61K39/00 , A61K38/20 , A61K39/395
CPC分类号： A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要： The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译： 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
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公开(公告)号：US20160038415A1
公开(公告)日：2016-02-11
申请号：US14741694
申请日：2015-06-17
发明人： Darrell J. Irvine , Jaehyun Moon
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
摘要翻译： 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡在其表面和/或内部包含带有末端半胱氨酸的抗原或半胱氨酸修饰的抗原。
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公开(公告)号：US20170266114A1
公开(公告)日：2017-09-21
申请号：US15452992
申请日：2017-03-08
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
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公开(公告)号：US20150272884A1
公开(公告)日：2015-10-01
申请号：US14581004
申请日：2014-12-23
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K9/127 , A61K45/06 , A61K38/20 , A61K39/395 , A61K39/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
摘要翻译： 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡可以包含预防性，治疗和/或诊断剂。
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公开(公告)号：US20180185473A1
公开(公告)日：2018-07-05
申请号：US15673126
申请日：2017-08-09
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K39/385 , A61K47/69 , A61K9/127 , A61K38/20 , A61K39/21
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
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公开(公告)号：US09616020B2
公开(公告)日：2017-04-11
申请号：US15097607
申请日：2016-04-13
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K9/127 , A61K38/20 , A61K45/06 , A61K39/21 , A61K39/39 , C07K14/005 , A61K39/12 , A61K39/35 , C07K16/28 , A61K39/395 , A61K31/437 , A61K31/713 , A61K38/19 , A61K47/48 , C12N7/00 , A61K39/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
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