公开(公告)号：US20180185286A1

公开(公告)日：2018-07-05

申请号：US15301221

申请日：2015-03-31

Applicant: NOVARTIS PHARMA AG ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Allan Stuart Myerson ,  Xiaochuan Yang ,  Marcus O'Mahony ,  Markus Krumme ,  Norbert Rasenack ,  Leia Dwyer

IPC: A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/192 ,  A61K31/216 ,  A61K31/343 ,  A61K9/16

CPC classification number: A61K9/143 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/485 ,  A61K31/192 ,  A61K31/216 ,  A61K31/277 ,  A61K31/343 ,  A61K31/397 ,  A61K31/405 ,  A61K31/4196 ,  A61K31/4422 ,  A61K31/496 ,  A61K31/64

Abstract: Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or dissolution rates for pharmaceutically active species having poor aqueous solubility.

公开(公告)号：US20170312674A1

公开(公告)日：2017-11-02

申请号：US15372124

申请日：2016-12-07

Applicant: Massachusetts Institute of Technology

Inventor： Allan Stuart Myerson ,  Marcus O'Mahony

IPC: B01D43/00 ,  B01D36/00

CPC classification number: B01D43/00 ,  B01D36/008 ,  C02F11/121 ,  C02F11/14

Abstract: The present disclosure is generally related to the separation of liquids from solids and for the recovery of solids and/or liquids from slurries. In some embodiments, liquids are separated from solids by applying a reduced pressure. In some embodiments, slurries are flowed by applying a pressure gradient. In some embodiments, an apparatus is provided that comprises a channel, an inlet, an outlet, and one or more ports. One or more ports may be constructed and arranged to apply a pressure differential and/or a reduced pressure to the channel. Such systems and methods may, in some embodiments, facilitate continuous manufacturing of solid products.

公开(公告)号：US20150196489A1

公开(公告)日：2015-07-16

申请号：US14575069

申请日：2014-12-18

Applicant: Massachusetts Institute of Technology

Inventor： Huseyin Burak Eral ,  Vilmali Lopez-Mejias ,  Allan Stuart Myerson ,  Bernhardt Levy Trout ,  Patrick S. Doyle ,  Marcus O'Mahony

IPC: A61K9/14 ,  A61K31/216

CPC classification number: A61K31/216 ,  A61K9/1617 ,  A61K9/1652

Abstract: Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.

Abstract translation: 通常描述用于控制试剂结晶的组合物，方法和系统。 在一些实施方案中，试剂在聚合物基质如聚合物颗粒存在下结晶。 聚合物基质可能影响结晶过程的至少一部分和/或所得组合物。 在一些这样的实施方案中，聚合物基质允许控制和/或改变方法和/或组合物的一个或多个方面。 例如，聚合物基质可以作为结晶剂的结晶促进剂和/或可接受的载体。 在某些实施方案中，本文所述的聚合物基质可以与任何试剂一起使用，而不管其化学和/或物理性质。

公开(公告)号：US10155786B2

公开(公告)日：2018-12-18

申请号：US15530181

申请日：2016-12-08

Applicant: Massachusetts Institute of Technology

Inventor： Allan S. Myerson ,  Marcus O'Mahony ,  Torsten Stelzer ,  Yuqing Cui

IPC: B01J19/00 ,  C07H17/08 ,  B01D9/00 ,  C07C213/10

Abstract: The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.

公开(公告)号：US20170166601A1

公开(公告)日：2017-06-15

申请号：US15530181

申请日：2016-12-08

Applicant: Massachusetts Institute of Technology

Inventor： Allan S. Myerson ,  Marcus O'Mahony ,  Torsten Stelzer ,  Yuqing Cui

IPC: C07H17/08 ,  B01D9/00 ,  C07C213/10

CPC classification number: C07H17/08 ,  B01D9/0004 ,  B01D9/0013 ,  B01D9/0031 ,  B01D9/0036 ,  B01D9/0054 ,  C07B2200/13 ,  C07C213/10

Abstract: The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.