公开(公告)号：US10780410B2

公开(公告)日：2020-09-22

申请号：US15504049

申请日：2015-08-14

Applicant: Massachusetts Institute of Technology

Inventor： Klavs F. Jensen ,  Timothy F. Jamison ,  Allan S. Myerson ,  Jean-Christophe M. Monbaliu ,  Mohsen Behnam ,  Shin Yee Wong ,  Nopphon Weeranoppanant ,  Eve Marie Revalor ,  Torsten Stelzer ,  Jie Chen ,  Andrea Adamo ,  David R. Snead ,  Ping Zhang

IPC: B01J19/00 ,  B01J19/18 ,  A61K31/14 ,  A61K31/167

Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

公开(公告)号：US20200368710A1

公开(公告)日：2020-11-26

申请号：US16988827

申请日：2020-08-10

Applicant: Massachusetts Institute of Technology

Inventor： Klavs F. Jensen ,  Timothy F. Jamison ,  Allan S. Myerson ,  Jean-Christophe M. Monbaliu ,  Mohsen Behnam ,  Shin Yee Wong ,  Nopphon Weeranoppanant ,  Eve Marie Revalor ,  Torsten Stelzer ,  Jie Chen ,  Andrea Adamo ,  David R. Snead ,  Ping Zhang

IPC: B01J19/00 ,  B01J19/18

Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

公开(公告)号：US20230201787A1

公开(公告)日：2023-06-29

申请号：US18086487

申请日：2022-12-21

Applicant: Massachusetts Institute of Technology

Inventor： Klavs F. Jensen ,  Timothy F. Jamison ,  Allan Stuart Myerson ,  Jean-Christophe M. Monbaliu ,  Mohsen Behnam ,  Shin Yee Wong ,  Nopphon Weeranoppanant ,  Eve Marie Revalor ,  Torsten Stelzer ,  Jie Chen ,  Andrea Adamo ,  David R. Snead ,  Ping Zhang

IPC: B01J19/00 ,  B01J19/18

CPC classification number: B01J19/004 ,  B01J19/0093 ,  B01J19/18 ,  B01J2219/00799 ,  B01J2219/00011 ,  B01J2219/0004 ,  B01J2219/00795 ,  B01J2219/00806 ,  B01J2219/00813 ,  B01J2219/00907 ,  B01J2219/00909 ,  B01J2219/00918 ,  B01J2219/00831 ,  B01J2219/0081 ,  B01J2219/00833 ,  B01J2219/00873 ,  B01J2219/00817 ,  B01J2219/00822 ,  B01J2219/00986 ,  B01J2219/00835 ,  B01J2219/00889 ,  B01J2219/00871 ,  B01J2219/0002 ,  A61K31/14

Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

公开(公告)号：US11565230B2

公开(公告)日：2023-01-31

申请号：US16988827

申请日：2020-08-10

Applicant: Massachusetts Institute of Technology

Inventor： Klavs F. Jensen ,  Timothy F. Jamison ,  Allan S. Myerson ,  Jean-Christophe M. Monbaliu ,  Mohsen Behnam ,  Shin Yee Wong ,  Nopphon Weeranoppanant ,  Eve Marie Revalor ,  Torsten Stelzer ,  Jie Chen ,  Andrea Adamo ,  David R. Snead ,  Ping Zhang

IPC: B01J19/00 ,  B01J19/18 ,  A61K31/14 ,  A61K31/167

Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

公开(公告)号：US10155786B2

公开(公告)日：2018-12-18

申请号：US15530181

申请日：2016-12-08

Applicant: Massachusetts Institute of Technology

Inventor： Allan S. Myerson ,  Marcus O'Mahony ,  Torsten Stelzer ,  Yuqing Cui

IPC: B01J19/00 ,  C07H17/08 ,  B01D9/00 ,  C07C213/10

Abstract: The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.

公开(公告)号：US20170166601A1

公开(公告)日：2017-06-15

申请号：US15530181

申请日：2016-12-08

Applicant: Massachusetts Institute of Technology

Inventor： Allan S. Myerson ,  Marcus O'Mahony ,  Torsten Stelzer ,  Yuqing Cui

IPC: C07H17/08 ,  B01D9/00 ,  C07C213/10

CPC classification number: C07H17/08 ,  B01D9/0004 ,  B01D9/0013 ,  B01D9/0031 ,  B01D9/0036 ,  B01D9/0054 ,  C07B2200/13 ,  C07C213/10

Abstract: The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.