公开(公告)号：US08563549B2

公开(公告)日：2013-10-22

申请号：US13471111

申请日：2012-05-14

申请人： Matthew Burger ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Gordana Ataliah ,  Sarah Bartulis ,  Kelly Frazier ,  Aaron Smith ,  Joelle Verhagen ,  Yanchen Zhang ,  Allan Wagman ,  Simon Ng ,  Keith Pfister ,  Daniel J. Poon ,  Alicia Louie ,  Teresa Pick ,  Paul Barsanti ,  Edwin Iwanowicz ,  Wendy Fantl ,  Thomas Hendrickson ,  Mark Knapp ,  Hanne Meritt ,  Charles Voliva ,  Marion Wiesmann ,  Xiahua Xin

发明人： Matthew Burger ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Gordana Ataliah ,  Sarah Bartulis ,  Kelly Frazier ,  Aaron Smith ,  Joelle Verhagen ,  Yanchen Zhang ,  Allan Wagman ,  Simon Ng ,  Keith Pfister ,  Daniel J. Poon ,  Alicia Louie ,  Teresa Pick ,  Paul Barsanti ,  Edwin Iwanowicz ,  Wendy Fantl ,  Thomas Hendrickson ,  Mark Knapp ,  Hanne Meritt ,  Charles Voliva ,  Marion Wiesmann ,  Xiahua Xin

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12

摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

公开(公告)号：US20100249126A1

公开(公告)日：2010-09-30

申请号：US12161537

申请日：2007-01-22

申请人： Matthew Burger ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Aaron Smith ,  Joelle Verhagen ,  Yanchen Zhang ,  Allan Wagman ,  Simon Ng ,  Keith Pfister ,  Daniel J. Poon ,  Alicia Louie ,  Teresa Pick ,  Paul Barsanti ,  Edwin Iwanowicz ,  Wendy Fantl ,  Thomas Hendrickson ,  Mark Knapp ,  Hanne Meritt ,  Charles Voliva ,  Marion Wiesmann ,  Xiahua Xin

发明人： Matthew Burger ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Aaron Smith ,  Joelle Verhagen ,  Yanchen Zhang ,  Allan Wagman ,  Simon Ng ,  Keith Pfister ,  Daniel J. Poon ,  Alicia Louie ,  Teresa Pick ,  Paul Barsanti ,  Edwin Iwanowicz ,  Wendy Fantl ,  Thomas Hendrickson ,  Mark Knapp ,  Hanne Meritt ,  Charles Voliva ,  Marion Wiesmann ,  Xiahua Xin

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12

摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

公开(公告)号：US08217035B2

公开(公告)日：2012-07-10

申请号：US12161537

申请日：2007-01-22

申请人： Matthew Burger ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Aaron Smith ,  Joelle Verhagen ,  Yanchen Zhang ,  Allan Wagman ,  Simon Ng ,  Keith Pfister ,  Daniel Poon ,  Alicia Louie ,  Teresa Pick ,  Paul Barsanti ,  Edwin Iwanowicz ,  Wendy Fantl ,  Thomas Hendrickson ,  Mark Knapp ,  Hanne Merritt ,  Charles Voliva ,  Marion Wiesmann ,  Xiaohua Xin

发明人： Matthew Burger ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Aaron Smith ,  Joelle Verhagen ,  Yanchen Zhang ,  Allan Wagman ,  Simon Ng ,  Keith Pfister ,  Daniel Poon ,  Alicia Louie ,  Teresa Pick ,  Paul Barsanti ,  Edwin Iwanowicz ,  Wendy Fantl ,  Thomas Hendrickson ,  Mark Knapp ,  Hanne Merritt ,  Charles Voliva ,  Marion Wiesmann ,  Xiaohua Xin

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12

摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

公开(公告)号：US20100075965A1

公开(公告)日：2010-03-25

申请号：US12279148

申请日：2007-02-14

申请人： Zhi-Jie Ni ,  Sabina Pecchi ,  Matthew Burger ,  Wooseok Han ,  Aaron Smith ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Joelle Verhagen ,  Yanchen Zhang ,  Ed Iwanowicz ,  Tom Hendrickson ,  Mark Knapp ,  Hanne Merritt ,  Charles Voliva ,  Marion Wiesmann ,  Darren Mark Legrand ,  Ian Bruce ,  James Dale ,  Jiong Lan ,  Barry Levine ,  Abran Costales ,  Jui Liu ,  Teresa Pick ,  Daniel Menezes

发明人： Zhi-Jie Ni ,  Sabina Pecchi ,  Matthew Burger ,  Wooseok Han ,  Aaron Smith ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Joelle Verhagen ,  Yanchen Zhang ,  Ed Iwanowicz ,  Tom Hendrickson ,  Mark Knapp ,  Hanne Merritt ,  Charles Voliva ,  Marion Wiesmann ,  Darren Mark Legrand ,  Ian Bruce ,  James Dale ,  Jiong Lan ,  Barry Levine ,  Abran Costales ,  Jui Liu ,  Teresa Pick ,  Daniel Menezes

IPC分类号： A61K31/5377 ,  C07D471/04 ,  C07D487/04 ,  C07D413/14 ,  A61K31/437 ,  A61K31/5025 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.

摘要翻译： 磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途 受体和磷酸酶。

公开(公告)号：US08173647B2

公开(公告)日：2012-05-08

申请号：US12449286

申请日：2008-02-06

申请人： Gordana Atallah ,  Sarah Bartulis ,  Matthew Burger ,  Hanne Merritt ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Aaron Smith ,  Charles Voliva ,  Allan Wagman ,  Yanchen Zhang

发明人： Gordana Atallah ,  Sarah Bartulis ,  Matthew Burger ,  Hanne Merritt ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Aaron Smith ,  Charles Voliva ,  Allan Wagman ,  Yanchen Zhang

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14

摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.

摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途， 炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。

公开(公告)号：US20100048547A1

公开(公告)日：2010-02-25

申请号：US12449286

申请日：2008-02-06

申请人： Gordana Atallah ,  Sarah Bartulis ,  Matthew Burger ,  Hanne Merritt ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Aaron Smith ,  Charles Voliva ,  Allan Wagman ,  Yanchen Zhang

发明人： Gordana Atallah ,  Sarah Bartulis ,  Matthew Burger ,  Hanne Merritt ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Aaron Smith ,  Charles Voliva ,  Allan Wagman ,  Yanchen Zhang

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61K31/538 ,  A61P29/00 ,  A61P35/00 ,  A61P11/00 ,  A61P37/08 ,  A61P37/00 ,  A61P9/00

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14

摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.

摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途， 炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。