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公开(公告)号：US20130017218A1
公开(公告)日：2013-01-17
申请号：US13577667
申请日：2011-02-11
申请人： Matthew K. Waldor
发明人： Matthew K. Waldor
IPC分类号： A61K39/02 , A61P37/04 , A61K39/112 , A61K39/104 , A61K39/106 , A61K39/108
CPC分类号： C12N1/36 , A61K39/00 , A61K2039/522 , C07K14/21 , C07K14/28 , Y02A50/47 , Y02A50/476
摘要： The present invention provides for a method of reducing the reactogenicity of live attentuated bacterial vaccines by deleting at least a portion (e.g., the TLR-5 stimulating domain of a flagellin protein) of at least one of the bacterial genes that encodes a flagellin from the bacterium genome. These vaccines are directed against enteric or non-enteric flagellin-producing bacteria. A particular embodiment provides for a live attenuated cholera vaccine having reduced reactogenicity.
摘要翻译： 本发明提供了一种通过将至少一部分（例如，鞭毛蛋白的TLR-5刺激结构域）鞭毛蛋白的一部分细菌基因从编码鞭毛蛋白的细菌基因中删除而降低活细菌疫苗的反应原性的方法 细菌基因组。 这些疫苗针对产生肠道或非肠道鞭毛蛋白的细菌。 具体实施方案提供具有降低的反应原性的活的减毒霍乱疫苗。
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3.发明授权Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells 失效治疗由Leu3 / CD4表型T细胞介导的自身免疫性疾病的方法
公开(公告)号：US4695459A
公开(公告)日：1987-09-22
申请号：US686126
申请日：1984-12-26
申请人： Lawrence Steinman , Matthew K. Waldor , Subramanian Sriram , Leonard A. Herzenberg , Leonore A. Herzenberg
发明人： Lawrence Steinman , Matthew K. Waldor , Subramanian Sriram , Leonard A. Herzenberg , Leonore A. Herzenberg
IPC分类号： C12N15/02 , A61K39/395 , A61P37/06 , C07K16/28 , C12P21/00 , C12P21/08 , C12R1/91 , A61K35/56
CPC分类号： C07K16/2812 , Y10S424/81 , Y10S514/825 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S530/868
摘要： Certain autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus may be prevented or attenuated by in vivo treatment with a complement-fixing anti-Leu3 (CD4) antibody that is cytotoxic to Leu3 (CD4) phenotype T cells.
摘要翻译： 某些自身免疫性疾病如多发性硬化症，类风湿性关节炎和系统性红斑狼疮可以通过使用对Leu3（CD4）表型T细胞具有细胞毒性的补体固定抗Leu3（CD4）抗体的体内治疗来预防或减弱。
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公开(公告)号：US08414903B2
公开(公告)日：2013-04-09
申请号：US12312739
申请日：2007-11-20
申请人： Matthew K. Waldor , Theresa D. Ho
发明人： Matthew K. Waldor , Theresa D. Ho
IPC分类号： A61K39/108 , A61K39/02 , A01N63/00 , C12P21/04 , C12N15/09
CPC分类号： C12N1/36 , A61K35/74 , A61K39/0258 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12N9/1205 , C12N9/1241 , C12N9/90 , Y02A50/474
摘要： The present invention provides methods and compositions for production of gram-negative bacterial mutants that are defective in intestinal colonization capacity and sensitive to infection by bacteriophage P1. Thus the present invention provides immunogenic compositions for the prevention or attenuation of food- and water-borne illnesses associated with ingestion of bacteria such as enterohemorrhagic Escherichia coli.
摘要翻译： 本发明提供了用于产生肠道定殖能力不良且对噬菌体P1感染敏感的革兰氏阴性细菌突变体的方法和组合物。 因此，本发明提供了用于预防或减少与摄入细菌如肠出血性大肠杆菌相关的食源性和水性疾病的免疫原性组合物。
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公开(公告)号：US20100092511A1
公开(公告)日：2010-04-15
申请号：US12312739
申请日：2007-11-20
申请人： Matthew K. Waldor , Theresa D. Ho
发明人： Matthew K. Waldor , Theresa D. Ho
CPC分类号： C12N1/36 , A61K35/74 , A61K39/0258 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12N9/1205 , C12N9/1241 , C12N9/90 , Y02A50/474
摘要： The present invention provides methods and compositions for production of gram-negative bacterial mutants that are defective in intestinal colonization capacity and sensitive to infection by bacteriophage P1. Thus the present invention provides immunogenic compositions for the prevention or attenuation of food- and water-borne illnesses associated with ingestion of bacteria such as enterohemorrhagic Escherichia coli.
摘要翻译： 本发明提供了用于产生肠道定殖能力不良且对噬菌体P1感染敏感的革兰氏阴性细菌突变体的方法和组合物。 因此，本发明提供了用于预防或减少与摄入细菌如肠出血性大肠杆菌相关的食源性和水性疾病的免疫原性组合物。
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公开(公告)号：US5945285A
公开(公告)日：1999-08-31
申请号：US882455
申请日：1997-06-26
摘要： The invention provides bacterial strains with increased sensitivity to antibiotics and methods for making and using the strains.
摘要翻译： 本发明提供对抗生素敏感性增加的细菌菌株以及制备和使用菌株的方法。
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