-
![6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors](/abs-image/US/2014/09/30/US08846712B2/abs.jpg.150x150.jpg)
1.发明授权6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors 有权6-（4-羟基 - 苯基）-3-苯乙烯基-1H-吡唑并[3,4-b]吡啶-4-甲酸酰胺衍生物作为激酶抑制剂公开(公告)号：US08846712B2
公开(公告)日：2014-09-30
申请号：US13230365
申请日：2011-09-12
申请人： Matthias Loehn , Maria Mendez-Perez , Stefania Pfeiffer-Marek , Aimo Kannt , Guillaume Begis , Olivier Duclos , Federic Jeannot
发明人： Matthias Loehn , Maria Mendez-Perez , Stefania Pfeiffer-Marek , Aimo Kannt , Guillaume Begis , Olivier Duclos , Federic Jeannot
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D413/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula I, in which R1, R2, R3, R4 and R5 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的吡唑并[3,4-b]吡啶化合物，其中R 1，R 2，R 3，R 4和R 5如下所定义。 式I的化合物是激酶抑制剂，并且可用于治疗与糖尿病和糖尿病并发症相关的疾病，例如糖尿病性肾病，糖尿病性神经病和糖尿病性视网膜病变。 本发明还涉及式I化合物，特别是作为药物中的活性成分的用途，以及包含它们的药物组合物。
-
![5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases](/abs-image/US/2015/03/10/US08975250B2/abs.jpg.150x150.jpg)
2.发明授权5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases 有权5氧代-5,8-二氢吡啶并[2,3-d]嘧啶衍生物作为治疗心血管疾病的CaMKII激酶抑制剂公开(公告)号：US08975250B2
公开(公告)日：2015-03-10
申请号：US13544209
申请日：2012-07-09
IPC分类号： C07D471/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P1/16 , A61P13/12 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P9/00 , A61P9/06 , A61P9/10 , C07D239/47
CPC分类号： C07D471/04
摘要： The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives having Formula (I) as defined herein, their preparation and their therapeutic use.
摘要翻译： 本发明涉及如本文所定义的具有式（I）的5-氧代-5,8-二氢吡啶并[2,3-d]嘧啶衍生物，其制备及其治疗用途。
-
3.发明申请公开(公告)号：US20110190340A1
公开(公告)日：2011-08-04
申请号：US13000202
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D217/24 , A61K31/472 , A61P9/12 , A61P9/10 , A61P13/12 , A61P35/00 , A61P25/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
-
4.发明授权公开(公告)号：US08541449B2
公开(公告)日：2013-09-24
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： C07D217/24 , A61K31/472
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
-
5.发明授权公开(公告)号：US08524737B2
公开(公告)日：2013-09-03
申请号：US13000202
申请日：2009-06-18
IPC分类号： C07D495/08 , C07D217/24 , A61K31/47
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
-
6.发明申请公开(公告)号：US20110190341A1
公开(公告)日：2011-08-04
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： A61K31/472 , C07D217/24 , A61P9/12 , A61P9/10 , A61P25/00 , A61P13/12 , A61P11/00 , A61P35/00 , A61P25/28
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
-
7.发明授权Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof 有权吡唑啉酮衍生物，其制备及其治疗用途公开(公告)号：US09169246B2
公开(公告)日：2015-10-27
申请号：US13245468
申请日：2011-09-26
申请人： Alexandre Benazet , Olivier Duclos , Nathalie Guillo , Gilbert Lassalle , Karim Macary , Valérie Vin
发明人： Alexandre Benazet , Olivier Duclos , Nathalie Guillo , Gilbert Lassalle , Karim Macary , Valérie Vin
IPC分类号： C07D471/04 , A61K31/551 , A61K9/20
CPC分类号： C07D471/04 , A61K9/2054 , Y02A50/492
摘要： The invention relates to compounds corresponding to formula (I) in which R1, R2 and R3 are as defined in Claim 1, and also to the process for preparing them and to their therapeutic use.
摘要翻译： 本发明涉及对应于式（I）的化合物，其中R 1，R 2和R 3如权利要求1所定义，以及其制备方法及其治疗用途。
-
8.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
-
9.发明授权2-amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors 有权2-氨基-3-（咪唑-2-基） - 吡啶-4-酮衍生物及其作为VEGF受体激酶抑制剂的用途公开(公告)号：US09126972B2
公开(公告)日：2015-09-08
申请号：US14117750
申请日：2012-05-16
申请人： Alain Braun , Olivier Duclos , Gilbert Lassalle , Franz Lorge , Valerie Martin , Olaf Ritzeler , Aurelie Strub
发明人： Alain Braun , Olivier Duclos , Gilbert Lassalle , Franz Lorge , Valerie Martin , Olaf Ritzeler , Aurelie Strub
IPC分类号： C07D471/04 , C07D401/14 , C07D401/04 , A61K31/4709 , A61K31/4375 , A61K45/06
CPC分类号： A61K31/4709 , A61K31/4375 , A61K45/06 , C07D401/04 , C07D471/04
摘要： The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物：制备方法和治疗用途。
-
10.发明授权Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics 有权7-炔基-1,8-萘啶酮衍生物的制备方法及其在治疗中的应用公开(公告)号：US08470847B2
公开(公告)日：2013-06-25
申请号：US12631122
申请日：2009-12-04
申请人： Antoine Alam , Sandrine Biscarrat , Isabelle Blanc , Françoise Bono , Olivier Duclos , Gary Mccort
发明人： Antoine Alam , Sandrine Biscarrat , Isabelle Blanc , Françoise Bono , Olivier Duclos , Gary Mccort
IPC分类号： C07D471/02 , A01N43/42 , A61K31/44
CPC分类号： C07D213/73 , C07D213/82 , C07D471/04
摘要： The disclosure relates to 7-alkynyl-1,8-naphthyridones of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
摘要翻译： 本公开涉及式（I）的7-炔基-1,8-萘啶酮：其中R1，R2，R3和R4如本公开所定义，含有它们的组合物，其制备方法及其用途 在治疗。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.046 秒)
