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    DEVICES AND METHODS FOR SELECTIVELY LYSING CELLS
    4.
    发明申请
    DEVICES AND METHODS FOR SELECTIVELY LYSING CELLS 审中-公开
    用于选择性细胞的装置和方法

    公开(公告)号：US20080014627A1

    公开(公告)日：2008-01-17

    申请号：US11771972

    申请日：2007-06-29

    申请人： Adnan Merchant ,  Michael Holzbaur ,  Stephan Hoffmann ,  Doug Sutton ,  Mark Deem ,  Steve Pence

    发明人： Adnan Merchant ,  Michael Holzbaur ,  Stephan Hoffmann ,  Doug Sutton ,  Mark Deem ,  Steve Pence

    IPC分类号： C12N1/06

    CPC分类号： A61M37/0092

    摘要： A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; and a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle.

    摘要翻译： 一种用于在气体和液体混合物和注射装置中产生微泡的装置，所述装置包括限定混合室的壳体; 用于混合包含在混合室中的溶液以在溶液中产生微泡的装置; 以及可拆卸地附接到所述壳体并与所述混合室流体连接的针阵列，所述针阵列包括至少一个针。

    Apparatus and method for ablating tissue
    5.
    发明申请
    Apparatus and method for ablating tissue 审中-公开
    用于消融组织的装置和方法

    公开(公告)号：US20070299435A1

    公开(公告)日：2007-12-27

    申请号：US11646526

    申请日：2006-12-28

    申请人： John E. Crowe ,  Jonathan L. Podmore ,  Michael Holzbaur

    发明人： John E. Crowe ,  Jonathan L. Podmore ,  Michael Holzbaur

    IPC分类号： A61N1/00

    CPC分类号： A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00363 ,  A61B2018/00577

    摘要： A device for ablating cardiac tissue includes a plurality of ablation elements substantially aligned along a common axis and adjustable between first and second predetermined positions. In the first predetermined position, the plurality of ablation elements form a curved contact surface. In the second predetermined position, the plurality of ablation elements form a substantially straight insertion configuration. At least one hinge may connect adjacent ones of the plurality of ablation elements. Each of the plurality of ablation elements may be located within a housing, which may have at least a portion of a hinge integrally formed therewith to connect adjacent ablation elements. Alternatively, a strand of superelastic material, such as a Nitinol wire, may interconnect ablation elements. The superelastic material may bias the plurality of ablation elements into at least one of the first and second predetermined positions.

    摘要翻译： 用于消融心脏组织的装置包括多个消融元件，其基本上沿公共轴线对准并且可在第一和第二预定位置之间调节。 在第一预定位置，多个消融元件形成弯曲的接触表面。 在第二预定位置，多个消融元件形成基本上直的插入构造。 至少一个铰链可以连接多个消融元件中的相邻的一个。 多个消融元件中的每一个可以位于壳体内，壳体可以具有与其一体形成的铰链的至少一部分以连接相邻的消融元件。 或者，一系列超弹性材料，例如镍钛诺丝，可以互连消融元件。 超弹性材料可以将多个消融元件偏置到第一和第二预定位置中的至少一个中。

    Ablation device and method comprising movable ablation elements
    6.
    发明授权
    Ablation device and method comprising movable ablation elements 失效
    消融装置和方法包括可动消融元件

    公开(公告)号：US07678109B2

    公开(公告)日：2010-03-16

    申请号：US11642821

    申请日：2006-12-21

    申请人： Jonathan L. Podmore ,  Michael Holzbaur

    发明人： Jonathan L. Podmore ,  Michael Holzbaur

    IPC分类号： A61B18/18

    CPC分类号： A61N7/022 ,  A61B18/14 ,  A61B18/24 ,  A61B2017/00243 ,  A61N2007/0078

    摘要： A device for ablating tissue includes an elongate body, which may be flexible to wrap about a cardiac structure, and at least one movable ablation element coupled to the body. The movable ablation element is adjustable relative to the body to form an angle with a longitudinal axis thereof between about zero degrees and about 180 degrees. The movable ablation element may be a two element array, and a pivot pin may depend from an underside thereof to pivotably connect the array to the body via a mating pivot hole in the body. The body may be formable into both a substantially flat configuration and a generally curved configuration. In other embodiments, the body is wand-shaped. The device may further include at least one non-movable ablation element coupled to the body and forming an angle of about zero degrees with the longitudinal axis of the body.

    摘要翻译： 用于消融组织的装置包括细长体，其可以是柔性的围绕心脏结构包裹，以及耦合到身体的至少一个可移动消融元件。 可移动消融元件可相对于主体调节以与其纵向轴线形成约零度至约180度的角度。 可移动消融元件可以是双元件阵列，并且枢轴销可以从其下侧可以通过主体中的配合枢轴孔将阵列可枢转地连接到主体。 主体可以形成为基本平坦的构型和大致弯曲的构造。 在其他实施例中，身体是棒状的。 该装置还可以包括至少一个不可移动的消融元件，其联接到主体并与主体的纵向轴线形成大约零度的角度。

    Ablation device and method comprising movable ablation elements
    7.
    发明申请
    Ablation device and method comprising movable ablation elements 失效
    消融装置和方法包括可动消融元件

    公开(公告)号：US20070299436A1

    公开(公告)日：2007-12-27

    申请号：US11642821

    申请日：2006-12-21

    申请人： Jonathan L. Podmore ,  Michael Holzbaur

    发明人： Jonathan L. Podmore ,  Michael Holzbaur

    IPC分类号： A61B18/18

    CPC分类号： A61N7/022 ,  A61B18/14 ,  A61B18/24 ,  A61B2017/00243 ,  A61N2007/0078

    摘要： A device for ablating tissue includes an elongate body, which may be flexible to wrap about a cardiac structure, and at least one movable ablation element coupled to the body. The movable ablation element is adjustable relative to the body to form an angle with a longitudinal axis thereof between about zero degrees and about 180 degrees. The movable ablation element may be a two element array, and a pivot pin may depend from an underside thereof to pivotably connect the array to the body via a mating pivot hole in the body. The body may be formable into both a substantially flat configuration and a generally curved configuration. In other embodiments, the body is wand-shaped. The device may further include at least one non-movable ablation element coupled to the body and forming an angle of about zero degrees with the longitudinal axis of the body.

    摘要翻译： 用于消融组织的装置包括细长体，其可以是柔性的围绕心脏结构包裹，以及耦合到身体的至少一个可移动消融元件。 可移动消融元件可相对于主体调节以与其纵向轴线形成约零度至约180度的角度。 可移动消融元件可以是双元件阵列，并且枢轴销可以从其下侧可以通过主体中的配合枢轴孔将阵列可枢转地连接到主体。 主体可以形成为基本平坦的构型和大致弯曲的构造。 在其他实施例中，身体是棒状的。 该装置还可以包括至少一个不可移动的消融元件，其联接到主体并与主体的纵向轴线形成大约零度的角度。

    Device for ablation and visualization
    8.
    发明授权
    Device for ablation and visualization 有权
    消融和可视化设备

    公开(公告)号：US08052683B2

    公开(公告)日：2011-11-08

    申请号：US11642923

    申请日：2006-12-21

    申请人： Jonathan L. Podmore ,  Michael Holzbaur

    发明人： Jonathan L. Podmore ,  Michael Holzbaur

    IPC分类号： A61B18/14

    CPC分类号： A61B1/005 ,  A61B1/00087 ,  A61B1/0014 ,  A61B18/14 ,  A61B18/24 ,  A61B90/36 ,  A61B2017/00243 ,  A61B2017/00296 ,  A61B2018/1495 ,  A61B2090/306 ,  A61B2090/3614 ,  A61N7/022

    摘要： An ablation and visualization device includes a shaft, at least one ablation element coupled to the distal end of the shaft, and a scope coupled to the shaft proximate the distal end. The scope may be a fiber optic endoscope, an infrared sensor, or an ultrasound sensor, and may be coupled to an output device to display imagery collected by the scope. The scope includes at least one aperture, which may be movable. An optical element, such as a lens or filter, may be positioned over the aperture. The scope may be positioned laterally relative to the ablation elements or in a plane substantially parallel to and spaced apart from the ablation elements. The scope may be positioned with the aperture positioned distally or proximally relative to the ablation elements. The scope may be slidably or rotatably coupled to the shaft.

    摘要翻译： 消融和可视化装置包括轴，耦合到所述轴的远端的至少一个消融元件和靠近所述远端联接到所述轴的范围。 范围可以是光纤内窥镜，红外传感器或超声波传感器，并且可以耦合到输出设备以显示由示波器收集的图像。 该范围包括至少一个可以是可移动的孔。 诸如透镜或滤光器的光学元件可以定位在孔的上方。 所述范围可以相对于所述消融元件横向定位，或者在基本平行于并与所述消融元件间隔开的平面中。 范围可以定位成使孔相对于消融元件向远侧或向近侧定位。 该范围可以可滑动地或可旋转地联接到该轴。

    Device for ablation and visualization
    9.
    发明申请
    Device for ablation and visualization 有权
    消融和可视化设备

    公开(公告)号：US20070299437A1

    公开(公告)日：2007-12-27

    申请号：US11642923

    申请日：2006-12-21

    申请人： Jonathan L. Podmore ,  Michael Holzbaur

    发明人： Jonathan L. Podmore ,  Michael Holzbaur

    IPC分类号： A61B18/18

    CPC分类号： A61B1/005 ,  A61B1/00087 ,  A61B1/0014 ,  A61B18/14 ,  A61B18/24 ,  A61B90/36 ,  A61B2017/00243 ,  A61B2017/00296 ,  A61B2018/1495 ,  A61B2090/306 ,  A61B2090/3614 ,  A61N7/022

    摘要： An ablation and visualization device includes a shaft, at least one ablation element coupled to the distal end of the shaft, and a scope coupled to the shaft proximate the distal end. The scope may be a fiber optic endoscope, an infrared sensor, or an ultrasound sensor, and may be coupled to an output device to display imagery collected by the scope. The scope includes at least one aperture, which may be movable. An optical element, such as a lens or filter, may be positioned over the aperture. The scope may be positioned laterally relative to the ablation elements or in a plane substantially parallel to and spaced apart from the ablation elements. The scope may be positioned with the aperture positioned distally or proximally relative to the ablation elements. The scope may be slidably or rotatably coupled to the shaft.

    摘要翻译： 消融和可视化装置包括轴，耦合到所述轴的远端的至少一个消融元件和靠近所述远端联接到所述轴的范围。 范围可以是光纤内窥镜，红外传感器或超声波传感器，并且可以耦合到输出设备以显示由示波器收集的图像。 该范围包括至少一个可以是可移动的孔。 诸如透镜或滤光器的光学元件可以定位在孔的上方。 所述范围可以相对于所述消融元件横向定位，或者在基本平行于并与所述消融元件间隔开的平面中。 范围可以定位成使孔相对于消融元件向远侧或向近侧定位。 示范部件可以可滑动地或可旋转地联接到轴上。