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公开(公告)号：US07580737B2
公开(公告)日：2009-08-25
申请号：US10468432
申请日：2002-02-21
IPC分类号： A61B5/05
CPC分类号： A61B5/0275 , A61B5/4064 , A61B5/4076 , A61B5/412 , A61B6/00 , A61B6/481 , A61B6/504 , A61B6/507
摘要： A method and apparatus for evaluating acute stroke patients and for determining whether a stroke patient will benefit from the use of thrombolysis therapy includes obtaining measurements of the cerebral blood flow and cerebral blood volume of the brain of a stroke patient, determining ischemic areas of the brain where the ischemic areas comprise the measurements of cerebral blood flow which are less than a first value and creating a penumbra-infarct map of the ischemic areas of the brain using the measurements. The infarct area corresponds to the area of the brain where cerebral blood volume is less than a second value. The penumbra area corresponds to the area of the brain where cerebral blood volume is greater than this second dvalue. The method also includes determining a ratio of penumbra size to the total of penumbra size and infarct size. When the ratio is greater than a predetermined value, the stroke patient is a candidate for thrombolysis therapy.
摘要翻译： 用于评估急性中风患者和用于确定中风患者是否将从使用溶栓治疗中获益的方法和装置包括获得卒中患者的脑的脑血流量和脑血容量的测量值，确定脑的缺血区域 其中缺血区域包括小于第一值的脑血流量测量值，并使用测量值产生脑缺血区域的半暗带梗塞图。 梗塞区域对应于脑血容量小于第二值的脑区域。 半影区域对应于大脑的脑区域大于此第二d值。 该方法还包括确定半影大小与半暗影大小和梗塞面积的总和的比率。 当比率大于预定值时，中风患者是溶栓治疗的候选者。
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公开(公告)号：US06792302B2
公开(公告)日：2004-09-14
申请号：US09947058
申请日：2001-09-04
IPC分类号： A61B505
CPC分类号： A61B5/0275 , A61B5/4064 , A61B5/4076 , A61B5/412 , A61B6/00 , A61B6/481 , A61B6/504 , A61B6/507
摘要： A method and apparatus for evaluating acute stroke patients and for determining whether a stroke patient will benefit from the use of thrombolysis therapy includes obtaining measurements of the cerebral blood flow and cerebral blood volume of the brain of a stroke patient, determining ischemic areas of the brain where the ischemic areas comprise the measurements of cerebral blood flow which are less than a first value and creating a penumbra-infarct map of the ischemic areas of the brain using the measurements. The infarct area corresponds to the area of the brain where cerebral blood volume is less than a second value. The penumbra area corresponds to the area of the brain where cerebral blood volume is greater than this second value. The method also includes determining a ratio of penumbra size to the total of penumbra size and infarct size. When the ratio is greater than a predetermined value, the stroke patient is a candidate for thrombolysis therapy.
摘要翻译： 用于评估急性中风患者和用于确定中风患者是否将从使用溶栓治疗中获益的方法和装置包括获得卒中患者的脑的脑血流量和脑血容量的测量值，确定脑的缺血区域 其中缺血区域包括小于第一值的脑血流量测量值，并使用测量值产生脑缺血区域的半暗带梗塞图。 梗塞区域对应于脑血容量小于第二值的脑区域。 半影区域对应于大脑的脑区域大于此第二值。 该方法还包括确定半影大小与半暗影大小和梗塞面积的总和的比率。 当比率大于预定值时，中风患者是溶栓治疗的候选者。
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3.发明授权Image registration method and apparatus for medical imaging based on multiple masks 有权基于多个掩模的医学成像的图像配准方法和装置公开(公告)号：US07912259B2
公开(公告)日：2011-03-22
申请号：US11659887
申请日：2005-08-05
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/30048
摘要： An image registration method for use in medical imaging includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning may include: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation.
摘要翻译： 用于医学成像的图像配准方法包括以下步骤：提供每个图像序列，每个图像序列包括正在分析的身体部位的数字表示，选择序列内的参考图像，定义运动图像的序列的剩余图像 并且相对于参考图像重新对准运动图像的至少一部分。 重新对准的步骤可以包括：定义标识在参考图像上必须重新对齐运动图像的至少一部分的参考图像上的区域的定界掩模，以及标识参考图像上的另外区域的特征掩模 在其中计算重新对准，通过优化相似性度量来确定用于补偿运动图像相对于参考图像的位移的优化变换，以及根据优化的变换来变换运动图像的至少一部分。
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4.发明申请ADJUSTABLE STEREOTACTIC DEVICE AND METHOD FOR FRAMELESS NEUROSURGICAL STEREOTAXY 失效可调节的立体机器人和方法，用于无障碍神经外科手术公开(公告)号：US20110190789A1
公开(公告)日：2011-08-04
申请号：US12741533
申请日：2008-11-05
IPC分类号： A61B19/00
CPC分类号： A61B17/1739 , A61B34/10 , A61B90/11 , A61B2017/00707 , A61B2017/00725 , A61B2017/3405 , A61B2090/363 , A61B2090/3916 , A61B2090/3983 , A61B2090/3987
摘要： The system comprises at least three anchors (2,2′,2″) intended to be attached to the patient and equipped with markers (5,5′,5″), an insertion guide device (6) with an insertion guide (7) intended to be attached to said anchors (2,2′,2″), an external calibration device (8) with at least three calibration markers (10,10′,10″) corresponding to said markers (5,5′,5″) and a planning and imaging software. The planning and imaging software is used to determine the position of a target point in the patient with respect to the markers (5,5′,5″), the calibration device is used to calibrate and orient the insertion guide (7) of the insertion guide device (6) mounted on said calibration markers (10,10′,10″) using the determination of the software before the insertion guide device is mounted on said markers (5,5′,5″) attached to the patient.
摘要翻译： 该系统包括旨在附接到患者并配备有标记（5,5'，5“）的至少三个锚固件（2,2'，2”），具有插入引导件（7）的插入引导装置（6） ），具有与所述标记（5,5'，2“）对应的至少三个校准标记（10,10'，10”）的外部校准装置（8） 5“）和计划和成像软件。 计划和成像软件用于确定患者相对于标记（5,5'，5“）的目标点的位置，校准装置用于校准和定向患者的插入引导件（7） 插入引导装置（6），其在插入引导装置安装在附接到患者的所述标记（5,5'，5“）上之前使用软件的确定来安装在所述校准标记（10,10'，10”）上。
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公开(公告)号：US20080049994A1
公开(公告)日：2008-02-28
申请号：US11659887
申请日：2005-08-05
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/30048
摘要： An image registration method for use in medical imaging is proposed. The method includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning includes: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation. The similarity measure is calculated alternatively between: a) a first computation region identified on the reference image by a computation mask and a second computation region identified by the computation mask on the moving image transformed according to a proposed transformation, the computation mask being determined by the intersection between the feature mask and the delimitation mask transformed according to the proposed transformation, or b) a first computation region identified by a computation mask on the reference image transformed according to a proposed transformation and a second computation region identified by the computation mask on the moving image, the computation mask being determined by the intersection between the feature mask transformed according to the proposed transformation and the delimitation mask, or c) a first computation region identified on the reference image by a computation mask transformed according to the reverse of a proposed transformation and a second computation region identified by the computation mask on the moving image, the computation mask being determined by the intersection between the feature mask transformed according to the proposed transformation and the delimitation mask.
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6.发明授权Adjustable stereotactic device and method for frameless neurosurgical stereotaxy 失效可调节的立体定向装置和无框神经外科立体定向的方法公开(公告)号：US08617180B2
公开(公告)日：2013-12-31
申请号：US12741533
申请日：2008-11-05
IPC分类号： A61B19/00
CPC分类号： A61B17/1739 , A61B34/10 , A61B90/11 , A61B2017/00707 , A61B2017/00725 , A61B2017/3405 , A61B2090/363 , A61B2090/3916 , A61B2090/3983 , A61B2090/3987
摘要： The system comprises at least three anchors (2,2′,2″) intended to be attached to the patient and equipped with markers (5,5′,5″), an insertion guide device (6) with an insertion guide (7) intended to be attached to said anchors (2,2′,2″), an external calibration device (8) with at least three calibration markers (10,10′,10″) corresponding to said markers (5,5′,5″) and a planning and imaging software. The planning and imaging software is used to determine the position of a target point in the patient with respect to the markers (5,5′,5″), the calibration device is used to calibrate and orient the insertion guide (7) of the insertion guide device (6) mounted on said calibration markers (10,10′,10″) using the determination of the software before the insertion guide device is mounted on said markers (5,5′,5″) attached to the patient.
摘要翻译： 该系统包括至少三个锚定件（2,2'，2“），用于附接到患者并配备有标记（5,5'，5”），插入引导装置（6），其具有插入导向件 （7），旨在附接到所述锚定件（2,2'，2“），外部校准装置（8）具有对应于所述标记（5）的至少三个校准标记（10,10'，10”） ，5'，5“）和计划和成像软件。 规划和成像软件用于确定患者相对于标记（5,5'，5“）的目标点的位置，校准装置用于校准和定向插入引导件（7）的插入引导件 所述插入引导装置（6）在所述插入引导装置安装在所述标记（5,5'，5“）上之前，使用所述软件的确定来安装在所述校准标记（10,10'，10”）上， 患者。
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公开(公告)号：US20080139931A1
公开(公告)日：2008-06-12
申请号：US11795457
申请日：2006-01-13
申请人： Torsten Butz , Jean-Philippe Thiran , Murat Kunt
发明人： Torsten Butz , Jean-Philippe Thiran , Murat Kunt
CPC分类号： A61B8/5238 , A61B5/015 , A61B5/0507 , A61B8/08 , G06T7/33 , G06T7/35 , G06T2207/30004
摘要： Temperature imaging has been recognized to improve a variety of diagnostic and interventional procedures and to predict and prevent failures of electrical circuits and equipments. A system design and method is disclosed, wherein the thermal data is fused and mapped with the data streams coming from a US, CT, or MR scanner, giving the doctors or industrial investigators the impression of being working with a known US, CT, or MR system which has been augmented by the temperature mapping capability.
摘要翻译： 已经认识到温度成像可以改善各种诊断和介入程序，并预测和预防电路和设备的故障。 公开了一种系统设计和方法，其中热数据与来自美国，CT或MR扫描仪的数据流融合并映射，给予医生或工业调查员以与美国，美国，美国， 已经通过温度映射能力增强的MR系统。
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