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公开(公告)号：US10744326B2
公开(公告)日：2020-08-18
申请号：US14454427
申请日：2014-08-07
Applicant: Medtronic, Inc.
Inventor： Gary W. King , Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Jordan J. Greenberg , Kenneth T. Heruth , Mark S. Lent , Paul W. Wacnik
IPC: A61N1/36
Abstract: Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
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2.发明申请公开(公告)号：US20130282078A1
公开(公告)日：2013-10-24
申请号：US13826919
申请日：2013-03-14
Applicant: MEDTRONIC, INC.
Inventor： Paul W. Wacnik
IPC: A61N1/372
CPC classification number: A61N1/37252 , A61N1/36071 , A61N1/36132 , A61N1/3615 , A61N1/36164 , A61N1/37247
Abstract: A system may include a therapy delivery module configured to deliver electrical stimulation therapy to a tissue of a patient in accordance with a first stimulation therapy program. The first stimulation therapy program may define a first stimulation intensity below a perception threshold stimulation intensity of the patient. The therapy delivery module also may be configured to deliver electrical stimulation therapy to the tissue of the patient in accordance with a second stimulation therapy program. The second stimulation therapy program may define a second stimulation intensity at or above the perception threshold stimulation intensity. The system also may include a processor configured to determine stimulation parameter values for the first stimulation therapy program that result in a first volume of effect and determine stimulation parameter values for the second stimulation therapy program that result in a second volume of effect substantially the same as the first volume of effect.
Abstract translation: 系统可以包括治疗递送模块，其被配置为根据第一刺激治疗程序向患者的组织递送电刺激治疗。 第一刺激治疗程序可以定义低于患者的感知阈值刺激强度的第一刺激强度。 治疗递送模块还可以被配置为根据第二刺激治疗程序向患者的组织递送电刺激治疗。 第二刺激治疗程序可以定义在感知阈值刺激强度之上或之上的第二刺激强度。 该系统还可以包括处理器，其被配置为确定导致第一体积效应的第一刺激治疗程序的刺激参数值，并且确定第二刺激治疗程序的刺激参数值，其导致第二体积的效应基本相同 第一卷效果。
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公开(公告)号：US11154709B2
公开(公告)日：2021-10-26
申请号：US16377458
申请日：2019-04-08
Applicant: Medtronic, Inc.
Inventor： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, Jr. , Kenneth T. Heruth , Paul W. Wacnik , Jeffrey S. Evanson
Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
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公开(公告)号：US10300273B2
公开(公告)日：2019-05-28
申请号：US15082536
申请日：2016-03-28
Applicant: Medtronic, Inc.
Inventor： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, Jr. , Kenneth T. Heruth , Paul W. Wacnik , Jeffrey S. Evanson
Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
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公开(公告)号：US20160279411A1
公开(公告)日：2016-09-29
申请号：US15082536
申请日：2016-03-28
Applicant: Medtronic, Inc.
Inventor： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, JR. , Kenneth T. Heruth , Paul W. Wacnik , Jeffrey S. Evanson
CPC classification number: A61N1/36021 , A61M5/14 , A61M5/142 , A61M2205/054 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/0558 , A61N1/36017 , A61N1/36071 , A61N1/37211 , A61N1/375
Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
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Patent Agency Ranking
公开(公告)号：US20140155953A1
公开(公告)日：2014-06-05
申请号：US14176665
申请日：2014-02-10
Applicant: Medtronic, Inc.
Inventor： Paul W. Wacnik , Lisa M. Johanek
IPC: A61N1/36
CPC classification number: A61N1/36185 , A61N1/3605 , A61N1/36071
Abstract: In some examples, the disclosure relates to system, devices, and techniques for delivering dorsal column stimulation. One or more locations for dorsal column stimulation may be identified based on sensed signals evoked by delivery of stimulation to a dorsal root and/or peripheral nerve of a patient. In some examples, an IMD may deliver dorsal column stimulation in combination with dorsal root stimulation to a patient to treat a patient condition.
Abstract translation: 在一些示例中，本公开涉及用于递送背柱刺激的系统，装置和技术。 可以基于通过将刺激递送到患者的背根和/或周围神经而诱发的感测信号来识别用于背侧柱刺激的一个或多个位置。 在一些实例中，IMD可以将背根刺激与背根刺激结合提供给患者以治疗患者状况。
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公开(公告)号：US09155895B2
公开(公告)日：2015-10-13
申请号：US14176665
申请日：2014-02-10
Applicant: Medtronic, Inc.
Inventor： Paul W. Wacnik , Lisa M. Johanek
CPC classification number: A61N1/36185 , A61N1/3605 , A61N1/36071
Abstract: In some examples, the disclosure relates to system, devices, and techniques for delivering dorsal column stimulation. One or more locations for dorsal column stimulation may be identified based on sensed signals evoked by delivery of stimulation to a dorsal root and/or peripheral nerve of a patient. In some examples, an IMD may deliver dorsal column stimulation in combination with dorsal root stimulation to a patient to treat a patient condition.
Abstract translation: 在一些示例中，本公开涉及用于递送背柱刺激的系统，装置和技术。 可以基于通过将刺激递送到患者的背根和/或周围神经而诱发的感测信号来识别用于背侧柱刺激的一个或多个位置。 在一些实例中，IMD可以将背根刺激与背根刺激结合提供给患者以治疗患者状况。
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8.发明授权公开(公告)号：US08751009B2
公开(公告)日：2014-06-10
申请号：US13826919
申请日：2013-03-14
Applicant: Medtronic, Inc.
Inventor： Paul W. Wacnik
IPC: A61N1/36
CPC classification number: A61N1/37252 , A61N1/36071 , A61N1/36132 , A61N1/3615 , A61N1/36164 , A61N1/37247
Abstract: A system may include a therapy delivery module configured to deliver electrical stimulation therapy to a tissue of a patient in accordance with a first stimulation therapy program. The first stimulation therapy program may define a first stimulation intensity below a perception threshold stimulation intensity of the patient. The therapy delivery module also may be configured to deliver electrical stimulation therapy to the tissue of the patient in accordance with a second stimulation therapy program. The second stimulation therapy program may define a second stimulation intensity at or above the perception threshold stimulation intensity. The system also may include a processor configured to determine stimulation parameter values for the first stimulation therapy program that result in a first volume of effect and determine stimulation parameter values for the second stimulation therapy program that result in a second volume of effect substantially the same as the first volume of effect.
Abstract translation: 系统可以包括治疗递送模块，其被配置为根据第一刺激治疗程序向患者的组织递送电刺激治疗。 第一刺激治疗程序可以定义低于患者的感知阈值刺激强度的第一刺激强度。 治疗递送模块还可以被配置为根据第二刺激治疗程序向患者的组织递送电刺激治疗。 第二刺激治疗程序可以定义在感知阈值刺激强度之上或之上的第二刺激强度。 该系统还可以包括处理器，其被配置为确定导致第一体积效应的第一刺激治疗程序的刺激参数值，并且确定第二刺激治疗程序的刺激参数值，其导致第二体积的效应基本相同 第一卷效果。
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公开(公告)号：US20140114374A1
公开(公告)日：2014-04-24
申请号：US14144307
申请日：2013-12-30
Applicant: Medtronic, Inc.
Inventor： Ethan A. Rooney , Gary W. King , Carl D. Wahlstrand , Kenneth T. Heruth , Thomas E. Cross, JR. , Paul W. Wacnik , Richard T. Stone
IPC: A61N1/36
CPC classification number: A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/0558 , A61N1/36021 , A61N1/37205 , A61N1/37211 , A61N1/375 , A61N1/3756
Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
Abstract translation: 描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。 与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。 包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。 此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。
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公开(公告)号：US11752343B2
公开(公告)日：2023-09-12
申请号：US16985955
申请日：2020-08-05
Applicant: Medtronic, Inc.
Inventor： Gary W. King , Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Jordan J. Greenberg , Kenneth T. Heruth , Mark S. Lent , Paul W. Wacnik
IPC: A61N1/36
CPC classification number: A61N1/36139 , A61N1/36057 , A61N1/36071
Abstract: Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
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