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公开(公告)号：US20070184299A1
公开(公告)日：2007-08-09
申请号：US11619659
申请日：2007-01-04
申请人： Mei Wei , Haibo Qu , Xiaohua Yu
发明人： Mei Wei , Haibo Qu , Xiaohua Yu
IPC分类号： G11B11/105 , B05D1/36 , B32B19/00 , B32B9/00
CPC分类号： A61L27/306 , A61L27/56 , C23C18/1208 , C23C18/1229 , C23C18/127 , C23C18/1283 , C23C26/02 , Y10T428/26
摘要： A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
摘要翻译： 具有梯度密度/孔隙率和/或结合的生物活性剂的陶瓷涂层可以在基底表面上制造，包括可植入医疗器械的表面。
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公开(公告)号：US08007854B2
公开(公告)日：2011-08-30
申请号：US11619659
申请日：2007-01-04
申请人： Mei Wei , Haibo Qu , Xiaohua Yu
发明人： Mei Wei , Haibo Qu , Xiaohua Yu
IPC分类号： A61L33/00
CPC分类号： A61L27/306 , A61L27/56 , C23C18/1208 , C23C18/1229 , C23C18/127 , C23C18/1283 , C23C26/02 , Y10T428/26
摘要： A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
摘要翻译： 具有梯度密度/孔隙率和/或结合的生物活性剂的陶瓷涂层可以在基底表面上制造，包括可植入医疗器械的表面。
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公开(公告)号：US20110287167A1
公开(公告)日：2011-11-24
申请号：US13177054
申请日：2011-07-06
申请人： Mei Wei , Haibo Qu , Xiaohua Yu
发明人： Mei Wei , Haibo Qu , Xiaohua Yu
CPC分类号： A61L27/306 , A61L27/56 , C23C18/1208 , C23C18/1229 , C23C18/127 , C23C18/1283 , C23C26/02 , Y10T428/26
摘要： A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
摘要翻译： 具有梯度密度/孔隙率和/或结合的生物活性剂的陶瓷涂层可以在基底表面上制造，包括可植入医疗器械的表面。
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4.发明授权Calcium phosphate/structural protein composites and method of preparation thereof 有权磷酸钙/结构蛋白复合物及其制备方法公开(公告)号：US09149563B2
公开(公告)日：2015-10-06
申请号：US12265956
申请日：2008-11-06
IPC分类号： A61K33/42 , A61K38/39 , A61F2/28 , A61L27/52 , A61L24/00 , A61L24/10 , A61L27/12 , A61L27/46 , A61L27/56
CPC分类号： A61L27/52 , A61L24/0047 , A61L24/102 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2300/112 , A61L2430/02 , C08L89/06
摘要： Ceramic/structural protein composite scaffolds and their preparation in a simple one-step process are shown.
摘要翻译： 显示陶瓷/结构蛋白复合支架及其在简单的一步法中的制备。
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5.发明申请公开(公告)号：US20120003280A1
公开(公告)日：2012-01-05
申请号：US13231488
申请日：2011-09-13
CPC分类号： A61L27/32 , A61L27/34 , A61L2420/02 , A61L2420/04 , C08L89/06
摘要： Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates, including the surface of implantable medical devices.
摘要翻译： 公开了陶瓷/结构蛋白复合材料和制备方法，包括涂层和膜。 陶瓷/结构蛋白质涂层可以在衬底的表面上制造，包括可植入医疗器械的表面。
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6.发明申请公开(公告)号：US20090130456A1
公开(公告)日：2009-05-21
申请号：US12265979
申请日：2008-11-06
CPC分类号： A61L27/32 , A61L27/34 , A61L2420/02 , A61L2420/04 , C08L89/06
摘要： Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates, including the surface of implantable medical devices.
摘要翻译： 公开了陶瓷/结构蛋白复合材料和制备方法，包括涂层和膜。 陶瓷/结构蛋白质涂层可以在衬底的表面上制造，包括可植入医疗器械的表面。
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7.发明授权公开(公告)号：US08084095B2
公开(公告)日：2011-12-27
申请号：US12265979
申请日：2008-11-06
IPC分类号： B05D3/02
CPC分类号： A61L27/32 , A61L27/34 , A61L2420/02 , A61L2420/04 , C08L89/06
摘要： Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates, including the surface of implantable medical devices.
摘要翻译： 公开了陶瓷/结构蛋白复合材料和制备方法，包括涂层和膜。 陶瓷/结构蛋白质涂层可以在衬底的表面上制造，包括可植入医疗器械的表面。
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8.发明申请公开(公告)号：US20090130168A1
公开(公告)日：2009-05-21
申请号：US12265956
申请日：2008-11-06
IPC分类号： A61F2/02
CPC分类号： A61L27/52 , A61L24/0047 , A61L24/102 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2300/112 , A61L2430/02 , C08L89/06
摘要： Ceramic/structural protein composite scaffolds and their preparation in a simple one-step process are shown.
摘要翻译： 显示陶瓷/结构蛋白复合支架及其在简单的一步法中的制备。
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9.发明申请公开(公告)号：US20180280566A1
公开(公告)日：2018-10-04
申请号：US15472186
申请日：2017-03-28
申请人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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10.发明申请公开(公告)号：US20180280571A1
公开(公告)日：2018-10-04
申请号：US15472189
申请日：2017-03-28
申请人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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