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公开(公告)号：US07681738B2
公开(公告)日：2010-03-23
申请号：US11224347
申请日：2005-09-12
申请人： Meng H. Lean , Jeng Ping Lu , Scott J. Limb , Jürgen H. Daniel , Armin R. Völkel , Huangpin Ben Hsieh , Scott E. Solberg , Bryan T. Preas
发明人： Meng H. Lean , Jeng Ping Lu , Scott J. Limb , Jürgen H. Daniel , Armin R. Völkel , Huangpin Ben Hsieh , Scott E. Solberg , Bryan T. Preas
IPC分类号： B03B5/00
CPC分类号： B03C5/028
摘要： Various traveling wave grid configurations are disclosed. The grids and systems are well suited for transporting, separating, and classifying small particles dispersed in liquid or gaseous media. Also disclosed are various separation strategies and purification cells utilizing such traveling wave arrays and strategies.
摘要翻译： 公开了各种行波网格结构。 网格和系统非常适用于分散在液体或气体介质中的小粒子的运输，分离和分类。 还公开了利用这种行波阵列和策略的各种分离策略和纯化单元。
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2.发明授权Traveling wave grids and algorithms for biomolecule separation, transport and focusing 有权用于生物分子分离，运输和聚焦的旅行波网格和算法公开(公告)号：US07309410B2
公开(公告)日：2007-12-18
申请号：US10727301
申请日：2003-12-03
申请人： Meng H. Lean , Jeng Ping Lu , Jackson Ho , Chinwen Shih , Armin R. Völkel , Huangpin Ben Hsieh , Jurgen Daniel
发明人： Meng H. Lean , Jeng Ping Lu , Jackson Ho , Chinwen Shih , Armin R. Völkel , Huangpin Ben Hsieh , Jurgen Daniel
IPC分类号： G01N27/453
CPC分类号： G01N27/44773 , B03C5/028 , G01N27/44713 , G01N30/02
摘要： Various traveling wave grids and related systems are disclosed that are particularly beneficial for the separation, transport, and focusing of biomolecules or other charged species. An implementation of a vertically integrated traveling wave module is described which allows for scalability to arbitrary gel dimensions through tiling. In addition, several unique traveling wave algorithms are also described which when used in conjunction with the traveling wave grids, impart selective motion to biomolecules or other charged species.
摘要翻译： 公开了对生物分子或其他带电物质的分离，运输和聚焦特别有利的各种行波网格和相关系统。 描述了垂直集成的行波模块的实现，其允许通过平铺来扩展任意的凝胶尺寸。 此外，还描述了当与行波网格结合使用时，对生物分子或其他带电物质赋予选择性运动的几种独特的行波算法。
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公开(公告)号：US20120074074A1
公开(公告)日：2012-03-29
申请号：US12889495
申请日：2010-09-24
申请人： Meng H. Lean , Armin R. Völkel , Ashutosh Kole , Kai Melde , Huangpin Ben Hsieh
发明人： Meng H. Lean , Armin R. Völkel , Ashutosh Kole , Kai Melde , Huangpin Ben Hsieh
CPC分类号： B01D29/6476 , B01D29/6415 , B01D29/66 , B01D33/466 , B01D33/468 , B01D33/48 , B01D2201/583
摘要： A self-cleaning screen system and method removes contaminants from a fluid passed through a screen of the self-cleaning screen system. The self-cleaning screen system includes a cleaning mechanism used to remove contaminants which may have adhered to the screen. The self-cleaning screen system is self-powered by extracting energy from the fluid flow to cause rotation or other movement of either the screen and/or the cleaning mechanism.
摘要翻译： 自清洁屏幕系统和方法从通过自清洁屏幕系统的屏幕的流体中去除污染物。 自清洁屏幕系统包括用于去除可能附着在屏幕上的污染物的清洁机构。 自清洁屏幕系统通过从流体流中提取能量而引起屏幕和/或清洁机构的旋转或其他运动而自动供电。
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公开(公告)号：US07126134B2
公开(公告)日：2006-10-24
申请号：US10921556
申请日：2004-08-19
申请人： Meng H. Lean , Francisco E. Torres , Huangpin Ben Hsieh , Armin R. Völkel , Bryan Preas , Scott A. Elrod , John S. Fitch , Richard H. Bruce
发明人： Meng H. Lean , Francisco E. Torres , Huangpin Ben Hsieh , Armin R. Völkel , Bryan Preas , Scott A. Elrod , John S. Fitch , Richard H. Bruce
IPC分类号： G21K5/10
CPC分类号： B03C1/253
摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.
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公开(公告)号：US07121157B2
公开(公告)日：2006-10-17
申请号：US10913940
申请日：2004-08-06
CPC分类号： G01N1/08
摘要： Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.
摘要翻译： 公开了用于从表面收集样品，特别是微量的生物剂或微粒的紧凑的非接触装置。 该装置使含有样品的目标表面的区域振动，并在充电的针阵列上收集样品。 样品可以随后释放到检测器或其他仪器进行后续分析。
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6.发明授权Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids 有权使用行波网格集中和聚焦生物剂和微米级颗粒公开(公告)号：US07163611B2
公开(公告)日：2007-01-16
申请号：US10727289
申请日：2003-12-03
IPC分类号： B01D57/02
CPC分类号： G01N33/5438
摘要： Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.
摘要翻译： 公开了几种可以用于浓缩和形成高度局部化的生物剂或其他带电物质区域的行波系统。 此外，描述了使得目前可用的检测器和传感器（包括将来要开发的检测器和传感器）能够用于测量某些生物试剂或带电粒子的存在和浓度的具体检测系统，否则其浓度也是以浓度存在 低易于检测或测量。
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7.发明授权Traveling wave algorithms to focus and concentrate proteins in gel electrophoresis 有权旅行波算法聚焦和浓缩蛋白质在凝胶电泳公开(公告)号：US07282129B2
公开(公告)日：2007-10-16
申请号：US10460137
申请日：2003-06-12
申请人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
发明人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
IPC分类号： G01N27/447
CPC分类号： G01N27/44713
摘要： An electrophoretic cell configuration and related method are disclosed that employ oppositely directed traveling electrical waves. The waves travel across the cell and samples undergoing separation. Various strategies are used to selectively direct the movement and arrangement of the samples and resulting sample patterns.
摘要翻译： 公开了采用相反方向的行进电波的电泳池配置和相关方法。 波浪穿过细胞并进行分离。 使用各种策略来选择性地指导样品的移动和排列以及所得样品图案。
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8.发明授权Distributed multi-segmented reconfigurable traveling wave grids for separation of proteins in gel electrophoresis 有权分布式多分段可重构行波网格，用于在凝胶电泳中分离蛋白质公开(公告)号：US07156970B2
公开(公告)日：2007-01-02
申请号：US10459799
申请日：2003-06-12
申请人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
发明人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44713
摘要： Various traveling wave grids and electrophoretic systems, and electrode assemblies using such grids, are disclosed. A configuration in which a voltage potential is used to load a biomolecule sample against a grid is disclosed. A unique strategy of using multiple, reconfigurable grids in such systems is also described. The strategy involves initially conducting a broad protein separation and then selectively tailoring one or more grids, and conducting one or more secondary processing operations. Related strategies and specific methods are additionally disclosed for separating samples of biomolecules and components thereof using the noted systems, assemblies, and grids.
摘要翻译： 公开了各种行波网格和电泳系统以及使用这种格栅的电极组件。 公开了一种使用电压电位将生物分子样品装载在电网上的结构。 还描述了在这种系统中使用多个可重构网格的独特策略。 该策略首先进行广泛的蛋白质分离，然后选择性地定制一个或多个网格，以及进行一个或多个二次加工操作。 另外公开了使用所述系统，组件和网格分离生物分子及其组分的样品的相关策略和具体方法。
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9.发明授权Isoelectric focusing (IEF) of proteins with sequential and oppositely directed traveling waves in gel electrophoresis 有权蛋白质的等电聚焦（IEF）在凝胶电泳中具有顺序和相对定向的行波公开(公告)号：US07150813B2
公开(公告)日：2006-12-19
申请号：US10460724
申请日：2003-06-12
申请人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
发明人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
IPC分类号： B01D57/02
CPC分类号： G01N27/44795 , G01N27/44713
摘要： Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced operating voltages, and produce analytical results with improved resolution.
摘要翻译： 公开了各种凝胶电泳组件和技术，用于提供独特的等电聚焦（IEF）策略。 提供了几个特定的系统，组件和方法，其显着地减少了处理时间，使得能够使用降低的工作电压，并且以改进的分辨率产生分析结果。
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公开(公告)号：US08354076B2
公开(公告)日：2013-01-15
申请号：US11537679
申请日：2006-10-02
申请人： Jürgen H. Daniel , Meng H. Lean , Armin R. Völkel
发明人： Jürgen H. Daniel , Meng H. Lean , Armin R. Völkel
CPC分类号： B01F11/0077 , B01F11/0088 , B01F11/0091 , B01F13/0059 , B01L3/5027
摘要： A fluidic system and method includes a channel reservoir which holds 1.5 milliliters or less of fluid. The agitation mechanism, which is partially integrated with the channel or reservoir, includes a fiber or rod at least partially situated within the channel or reservoir, and which acts to move or vibrate to stir and/or agitate fluid within the channel or reservoir. The fluid is then extracted from an extraction area following the agitation or stirring operation.
摘要翻译： 流体系统和方法包括容纳1.5毫升或更少流体的通道储存器。 与通道或贮存器部分整合的搅拌机构包括至少部分地位于通道或贮存器内的纤维或杆，并且其作用为移动或振动以搅动和/或搅动通道或储存器内的流体。 然后在搅拌或搅拌操作之后从提取区域中提取流体。
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