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    USE OF PROBIOTICS TO AMELIORATE DIET-INDUCED INSULIN RESISTANCE
    7.
    发明申请
    USE OF PROBIOTICS TO AMELIORATE DIET-INDUCED INSULIN RESISTANCE 审中-公开
    使用益生菌来改善胰岛素诱导的胰岛素抵抗

    公开(公告)号：US20120027737A1

    公开(公告)日：2012-02-02

    申请号：US13256852

    申请日：2010-03-19

    申请人： Thomas Dyrmann Leser ,  Thomas Gunnarsson ,  Jens Kildsgaard ,  Janni Wandahl Pedersen ,  Bénédicte Flambard

    发明人： Thomas Dyrmann Leser ,  Thomas Gunnarsson ,  Jens Kildsgaard ,  Janni Wandahl Pedersen ,  Bénédicte Flambard

    IPC分类号： A61K35/74 ,  A61P1/14 ,  A61P1/00 ,  C12N1/20 ,  A61P3/04

    CPC分类号： A61K35/747 ,  A23L33/135 ,  A23V2002/00 ,  A23V2200/3204 ,  A23V2200/328

    摘要： The invention relates to the use of a composition comprising probiotic bacteria that regulate expression of key components involved in diet-induced insulin resistance for ameliorating or preventing diet-induced insulin resistance. The use of the probiotic strain and/or a fraction of said strain and/or metabolite of said strain for the manufacture of a medicament or a food or feed product to ameliorate diet-induced insulin resistance and help to obtain optimal body weight of a mammal is disclosed. Preferably, the composition comprises at least one probiotic Lactobacillus acidophilus strain and/or a fraction of said strain and/or metabolite of said strain for ameliorating or preventing diet-induced insulin resistance, said composition characterized by up-regulating expression of the ANGPTL4 gene encoding for FIAF in the intestine, down-regulating expression of the Elovl6 gene in the intestine as well as down-regulating expression of the SCD1 gene in skeletal muscles of a mammal, and wherein the probiotic strain is selected from the group of strains consisting of Lactobacillus acidophilus strain LA-5 (DSM13241).

    摘要翻译： 本发明涉及包含调节饮食诱导的胰岛素抵抗的关键成分的表达以改善或预防饮食诱导的胰岛素抵抗的益生菌的组合物的用途。 益生菌菌株和/或所述菌株和/或所述菌株的代谢物的一部分用于制造药物或食品或饲料产品以改善饮食诱导的胰岛素抵抗并有助于获得哺乳动物的最佳体重 被披露。 优选地，组合物包含至少一种益生菌嗜酸乳杆菌菌株和/或所述菌株和/或所述菌株的代谢物的级分，用于改善或预防饮食诱导的胰岛素抵抗，所述组合物的特征在于上调编码的ANGPTL4基因的表达 用于肠内的FIAF，下调Elovl6基因在肠中的表达，以及下调哺乳动物骨骼肌中SCD1基因的表达，其中益生菌菌株选自乳杆​​菌属 嗜酸菌菌株LA-5（DSM13241）。