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12 条记录 (耗时 0.032 秒)

    Hand orthosis
    5.
    发明授权
    Hand orthosis 有权
    手矫正

    公开(公告)号：US07837641B2

    公开(公告)日：2010-11-23

    申请号：US12120917

    申请日：2008-05-15

    申请人： Michael A. Hoffman

    发明人： Michael A. Hoffman

    IPC分类号： A61F5/00

    CPC分类号： A61F5/05866

    摘要： A hand orthosis assembly comprising a substantially rigid splint member having an inner wrist portion configured to receive a person's inner wrist and an arcuate palm portion extending from the wrist portion to receive the person's cupped hand. The arcuate palm portion may defining a cavity adapted to releasably retain a tool or recreational device, or an interchangeable insert releasably retained within the cavity, for generally gripping a tool or recreational device for functional use. The assembly may additionally include two or more protrusions extending from an outer perimeter of the arcuate portion for maintaining the persons' fingers in generally correct alignment. The assembly may also include a hook portion extending from the arcuate palm portion, having an assisting member extending therefrom for handling objects. The assisting member may be magnetic or affixed to magnetic material.

    摘要翻译： 一种手矫正组件，其包括基本上刚性的夹板构件，所述夹板构件具有构造成容纳人的内腕的内腕部和从所述腕部延伸以接收所述人的手掌的弓形手掌部。 弓形手掌部分可以限定适于可释放地保持工具或娱乐装置的空腔或可释放地保持在腔内的可互换插入件，用于大体上夹持用于功能使用的工具或娱乐装置。 组件还可以包括从弓形部分的外周延伸的两个或更多个突起，用于将人的手指保持在大致正确的对准中。 组件还可以包括从弓形手掌部分延伸的钩部，其具有从其延伸用于处理物体的辅助构件。 辅助部件可以是磁性的或固定在磁性材料上。

    Fluorescent-particle analyzer with timing alignment for analog pulse subtraction of fluorescent pulses arising from different excitation locations
    6.
    发明授权
    Fluorescent-particle analyzer with timing alignment for analog pulse subtraction of fluorescent pulses arising from different excitation locations 失效
    具有定时对准的荧光粒子分析仪，用于模拟脉冲减除由不同激发位置产生的荧光脉冲

    公开(公告)号：US5682038A

    公开(公告)日：1997-10-28

    申请号：US417744

    申请日：1995-04-06

    申请人： Michael A. Hoffman

    发明人： Michael A. Hoffman

    IPC分类号： G01N15/14 ,  G01J1/58 ,  G01J3/51 ,  G01N21/64 ,  G01N33/48

    CPC分类号： G01N15/14 ,  G01N2015/1438

    摘要： A flow cytometry system includes a flow tube through which particles marked with different fluorochromes pass from a first location, illuminated by a red laser, to a second location, illuminated by a blue laser. A "red" photodetector is optically coupled to detect red fluorescence from both locations. "Yellow" and "green" photodetectors respectively detect yellow and green fluorescence from the second location, while a "scattered light" detector detects scattered light from the second location. During a sample run, the red photodetector can output pulses that correspond primarily to APC fluorochrome at the first location and to PerCP at the second location respectively. A delay device delays the APC pulse relative to the PerCP pulse so that the peaks can be scaled and subtracted in the analog electrical domain to remove APC/PerCP crosstalk. The delay is calibrated using a set of APC tagged cells. Each of these cells generates a red fluorescence electrical pulse while at the first location and a scattered light pulse while at the second location. The average time differential between these two pulses for the set of timing cells determines the target delay. This is compared with the actual delay imposed by the delay device. If the error is greater than 0.5 .mu.S, the imposed delay can be adjusted until the delay is below 0.5 .mu.S, or within the tolerance required for reliable difference pulses to be generated by the pulse subtractor.

    摘要翻译： 流式细胞术系统包括流管，通过该流管，用不同荧光染料标记的颗粒从由红色激光照射的第一位置通过由蓝色激光照射的第二位置。 “红”光电探测器被光耦合以从两个位置检测红色荧光。 “黄色”和“绿色”光电探测器分别从第二位置检测黄色和绿色荧光，而“散射光”检测器检测来自第二位置的散射光。 在采样运行期间，红色光电检测器可以分别输出在第一位置处主要对应于APC荧光染料的脉冲，并在第二位置输出脉冲。 延迟器件相对于PerCP脉冲延迟APC脉冲，从而可以在模拟电域中对峰值进行缩放和减去以消除APC / PerCP串扰。 使用一组APC标记的细胞校准延迟。 这些单元中的每一个在第一位置处产生红色荧光电脉冲，并在第二位置处产生散射光脉冲。 用于该组定时单元的这两个脉冲之间的平均时间差确定了目标延迟。 这与延迟装置施加的实际延迟进行比较。 如果误差大于0.5μs，则可以调整延迟时间，直到延迟低于0.5μs，或者在由脉冲减法器产生的可靠差分脉冲所需的公差内。

    High speed memory packaging scheme
    7.
    发明授权
    High speed memory packaging scheme 失效
    高速内存封装方案

    公开(公告)号：US5530623A

    公开(公告)日：1996-06-25

    申请号：US154577

    申请日：1993-11-19

    申请人： Ikuo J. Sanwo ,  Michael A. Hoffman ,  Hyung S. Kim

    发明人： Ikuo J. Sanwo ,  Michael A. Hoffman ,  Hyung S. Kim

    IPC分类号： H05K1/02 ,  H05K1/14 ,  H05K3/36 ,  H05K7/14 ,  H01R9/09 ,  H01R23/70 ,  H01R29/00

    CPC分类号： H05K1/14 ,  H01R12/737 ,  H05K1/0237 ,  H05K1/141 ,  H05K2201/044 ,  H05K2201/10159 ,  H05K3/366

    摘要： A memory packaging scheme for high speed computer systems includes, several memory module sockets mounted to a printed circuit board and interconnected by a common set of address, data and control transmission lines within the printed circuit board. The transmission lines are interrupted at each connector. Cooperating memory modules, such as SIMM memory modules are installed in sequence into one or more of the module sockets in accordance with the requirements of the computer system. Installation of a memory module into a memory socket closes the open circuits for each one of the transmission lines at the memory socket, extending the uninterrupted length of the transmission lines to the next memory socket in the sequence. The memory socket and cooperating memory module design thus provides for sizing of the memory board transmission line lengths to accommodate the number of memory modules installed into memory board sockets, thereby eliminating undesirable transmission line effects from occurring within the printed circuit board transmission lines connecting the memory modules.

    摘要翻译： 用于高速计算机系统的存储器封装方案包括安装到印刷电路板并由印刷电路板内的一组共同的地址，数据和控制传输线互连的多个存储器模块插座。 传输线在每个连接器处中断。 根据计算机系统的要求，诸如SIMM存储器模块的协同存储器模块依次安装到一个或多个模块插槽中。 将存储器模块安装到存储器插槽中，封闭存储器插槽中每一条传输线路的开路，将传输线的不间断长度按顺序延伸到下一个存储器插槽。 因此，存储器插槽和配合存储器模块设计提供了存储器板传输线长度的尺寸以适应安装到存储器板插槽中的存储器模块的数量，从而消除了在连接存储器的印刷电路板传输线内发生不期望的传输线效应 模块。

    Infectious clone for human parainfluenza virus type 3
    8.
    发明授权
    Infectious clone for human parainfluenza virus type 3 失效
    人类副流感病毒3型传染性克隆

    公开(公告)号：US06248578B1

    公开(公告)日：2001-06-19

    申请号：US09073492

    申请日：1998-05-06

    申请人： Amiya K. Banerjee ,  Michael A. Hoffman

    发明人： Amiya K. Banerjee ,  Michael A. Hoffman

    IPC分类号： C12N700

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2760/18621 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18652

    摘要： A system for generating recombinant, human parainfluenza virus, particularly infectious, recombinant, human parainfluenza virus type 3 (HPIV-3) is provided. In one embodiment, the system comprises a clone comprising a nucleotide sequence that encodes a full-length, positive sense, anti-genome of HPIV, and at least one support clone comprising a nucleotide sequence that encodes the HPIV P protein and the HPIV L protein. In another embodiment, the system further comprises a support clone which comprises a nucleotide sequence that encodes the HPIV NP protein. The present invention also provides a MAH clone which comprises a nucleotide sequence encoding the full-length, positive sense, anti-genome of HPIV-3. The clone also comprises an RNA polymerase promoter operatively linked to the HPIV-3 antigenome-encoding sequence. In a preferred embodiment, the clone further comprises a nucleotide sequence which encodes a ribozyme immediately downstream from the sequence encoding the HPIV-3 anti-genome. The present invention also relates to a method of preparing recombinant HPIV-3 virus having site-specific mutations in the HPIV-3 genome. The method comprises preparing a clone comprising a modified HPIV-3 antigenome-encoding sequence; introducing the modified HPIV-3 clone and support clones which comprise nucleotide sequences encoding an HPIV-3 P protein, an HPIV-3 L protein, and, preferably, an HPIV-3 NP protein into host cells; and culturing the host cells under conditions that allow for synthesis of the modified HPIV-3 antigenome and the L, P, and NP proteins of HPIV-3.

    摘要翻译： 提供了一种用于产生重组人副副流感病毒，特别是感染性重组人类副流感病毒3型（HPIV-3）的系统。 在一个实施方案中，系统包含克隆，其包含编码HPIV的全长，正义，抗基因组的核苷酸序列，以及至少一种支持克隆，其包含编码HPIV P蛋白和HPIV L蛋白的核苷酸序列 。 在另一个实施方案中，系统还包含支持克隆，其包含编码HPIV NP蛋白的核苷酸序列。 本发明还提供一种MAH克隆，其包含编码HPIV-3的全长，正义，抗基因组的核苷酸序列。 该克隆还包含可操作地连接到HPIV-3反向编码序列的RNA聚合酶启动子。 在优选的实施方案中，克隆还包含在编码HPIV-3抗基因组的序列的紧邻下游编码核酶的核苷酸序列。 本发明还涉及在HPIV-3基因组中制备具有位点特异性突变的重组HPIV-3病毒的方法。 该方法包括制备包含经修饰的HPIV-3反义瘤编码序列的克隆; 引入修饰的HPIV-3克隆并将包含编码HPIV-3P蛋白，HPIV-3L蛋白，以及优选HPIV-3 NP蛋白的核苷酸序列的克隆支持到宿主细胞中; 并在允许合成修饰的HPIV-3抗原组和HPIV-3的L，P和NP蛋白的条件下培养宿主细胞。

    Particle sorter with neutralized collection wells and method of using same
    10.
    发明授权
    Particle sorter with neutralized collection wells and method of using same 失效
    具有中和收集井的颗粒分选机及其使用方法

    公开(公告)号：US4538733A

    公开(公告)日：1985-09-03

    申请号：US542285

    申请日：1983-10-14

    申请人： Michael A. Hoffman

    发明人： Michael A. Hoffman

    IPC分类号： B07C5/36 ,  G01N15/14 ,  B07C5/342

    CPC分类号： G01N15/1404 ,  B07C5/36 ,  G01N2015/149

    摘要： An apparatus for sorting particles comprises a nozzle or the like for forming discrete droplets of particles from a flowing liquid stream containing those particles. A detector is provided for detecting particles in the stream. A charging electrode, responsive to the detector, charges some droplets of selective interest with a positive electrical charge and some with a negative electrical charge. Electrical deflecting plates deflect charged droplets of selective interest. Droplets of selective interest, charged with opposite polarities, are collected in a collection well inside which the electrical charge is substantially neutralized. A method for sorting particles, such as cells or the like, substantially in accordance with the above-described apparatus is another aspect of the present invention.

    摘要翻译： 用于分选颗粒的装置包括用于从含有这些颗粒的流动液体流形成颗粒的离散液滴的喷嘴等。 提供用于检测流中的颗粒的检测器。 响应于检测器的充电电极以正电荷和一些具有负电荷的电荷充电一些选择性感兴趣的液滴。 电偏转板偏转有选择性的带电液滴。 带有相反极性的选择性感兴趣的液滴收集在收集井内，电荷基本上被中和。 基本上根据上述装置分选诸如电池等的颗粒的方法是本发明的另一方面。