公开(公告)号：US20200022804A1

公开(公告)日：2020-01-23

申请号：US16587322

申请日：2019-09-30

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/08 ,  B33Y80/00

摘要： An implantable article for attaching tendons and/or ligaments to bone and/or cartilage, assemblies thereof, and methods of use thereof are provided. The article is configured for attaching at least one of a tendon and a ligament to at least one of bone and cartilage. The article comprises a membrane comprising a biological material that promotes cell growth. The membrane comprises a first end, a second end, a cavity, and an expandable portion. The second end is configured to be attached to at least one of the bone, the cartilage, the tendon, and the ligament. The cavity extends from the first end to the second end. The cavity is configured to receive the cell growth mixture from the open end. The expandable portion is positioned intermediate the first end and the second end and is configured to increase in size responsive to the cell growth mixture entering the cavity.

公开(公告)号：US10470872B1

公开(公告)日：2019-11-12

申请号：US16381503

申请日：2019-04-11

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/08 ,  B33Y80/00

摘要： An implantable article for attaching tendons and/or ligaments to bone and/or cartilage, assemblies thereof, and methods of use thereof are provided. The implantable article is configured for attaching at least one of a tendon and a ligament to at least one of bone and cartilage. The article comprises a membrane comprising a biological material that promotes cell growth. The membrane comprises an open end configured to receive a cell growth mixture, a closed end configured to be attached to the at least one of bone and cartilage, and a cavity extending from the open end to the closed end. The cavity is configured to receive the cell growth mixture from the open end.

公开(公告)号：US11091732B2

公开(公告)日：2021-08-17

申请号：US15600763

申请日：2017-05-21

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： C12M1/00 ,  A61K35/35 ,  A61L27/36 ,  A61M1/00 ,  C12N5/0775 ,  C12N5/077 ,  C12M1/26 ,  A61K31/436

摘要： Methods and devices are disclosed for processing stromal precursor cells (i.e., cells which can differentiate into connective tissue cells, such as in muscles, ligaments, or tendons) which can be obtained from fatty tissue extracts obtained via liposuction. Normal processing of a liposuction extract involves centrifugation, to concentrate the stromal cells into a semi-concentrated form called “spun fat”. That “spun fat” can then be treated by mechanical processing (such as pressure-driven extrusion through 0.5 mm holes) under conditions which can gently pry the stromal cells away from extra-cellular collagen fibers and other debris in the “spun fat”. The extruded mixture is then centrifuged again, to separate a highly-enriched population of stromal cells which is suited for injection back into the patient (along with platelet cells, if desired, to further promote tissue repair or regeneration).

公开(公告)号：US20210228331A1

公开(公告)日：2021-07-29

申请号：US15482711

申请日：2017-04-07

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/08

摘要： Sock-like and “button”-type surgical implants, as well as kits containing such devices for use by a surgeon during an operation, are disclosed for surgically reattaching a tendon or ligament to a bone. In sock-like implants, a “toe” portion (or “distal tip”) will receive and hold a bone dowel, which can be pressed into a hole drilled into a bone surface, to anchor and hold the implant in position. “Button” implants can use a “nipple” component to hold a bone dowel anchor. The remainder of either type of implant will contain specialized repair cells, including platelets and “stromal precursor cells”. These implants can be made from placental membranes, treated-collagen membranes or meshes, or other biological materials, to further enhance their ability to stimulate the reattachment of damaged tendons and ligaments to bones.

公开(公告)号：US10952871B2

公开(公告)日：2021-03-23

申请号：US15482696

申请日：2017-04-07

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/46 ,  A61M29/00 ,  A61F2/30

摘要： Surgical tools and kits are disclosed for repairing hyaline or meniscal cartilage, using membrane segments to protect and promote the growth and activity of cartilage-generating cells. These kits include: (i) a set of dilator tubes, adapted from similar tubes used in spinal surgery except shorter, that will allow a surgeon to progressively enlarge an insertion tunnel for inserting a membrane segment into an articulating joint that is being repaired; and, (ii) an assortment of membrane “tamping” devices, with smooth rounded “tamping heads” (or tips, etc.), and with a size and length that allow the tool tip to pass through the longest dilator tube while being held by the surgeon. Additional components (including disposable supplies) that can help facilitate these types of surgery can be included in any such kit, or in “supplemental” kits that can be bundled and shipped with these “primary” kits.

公开(公告)号：US12005048B2

公开(公告)日：2024-06-11

申请号：US17404276

申请日：2021-08-17

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61K31/436 ,  A61K35/35 ,  A61L27/36 ,  A61M1/00 ,  C12M1/00 ,  C12M1/26 ,  C12N5/077 ,  C12N5/0775

CPC分类号： A61K31/436 ,  A61K35/35 ,  A61L27/3633 ,  A61M1/63 ,  A61M1/71 ,  A61M1/892 ,  C12M33/10 ,  C12M47/04 ,  C12M47/08 ,  C12N5/0653 ,  C12N5/0667 ,  A61M1/895 ,  A61M2202/0014 ,  A61M2202/0021 ,  A61M2202/095 ,  A61M2205/3331 ,  A61M2205/3365

摘要： Methods and devices are disclosed for processing stromal precursor cells (i.e., cells which can differentiate into connective tissue cells, such as in muscles, ligaments, or tendons) which can be obtained from fatty tissue extracts obtained via liposuction. Normal processing of a liposuction extract involves centrifugation, to concentrate the stromal cells into a semi-concentrated form called “spun fat”. That “spun fat” can then be treated by mechanical processing (such as pressure-driven extrusion through 0.5 mm holes) under conditions which can gently pry the stromal cells away from extra-cellular collagen fibers and other debris in the “spun fat”. The extruded mixture is then centrifuged again, to separate a highly-enriched population of stromal cells which is suited for injection back into the patient (along with platelet cells, if desired, to further promote tissue repair or regeneration).

公开(公告)号：US20240180689A1

公开(公告)日：2024-06-06

申请号：US18529559

申请日：2023-12-05

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/08 ,  A61L27/38 ,  A61L27/50

CPC分类号： A61F2/0805 ,  A61F2/0811 ,  A61L27/386 ,  A61L27/50

摘要： A method for repairing at least one of a tendon and a ligament in a joint region of a patient is provided. The method comprises inserting a tube, a needle, or a combination thereof into the joint region and proximal to the at least one of a tendon and a ligament. An implantable membrane is inserted into the tube, onto the needle, or a combination thereof, in the joint region. The implantable membrane comprises a biological material that promotes cell growth. The tube, the needle, or both is removed from the joint region while leaving the implantable member in the joint region and the implantable membrane contacted with the at least one of the tendon and the ligament. The method comprises securing the implantable membrane in the joint region.

公开(公告)号：US20190388239A9

公开(公告)日：2019-12-26

申请号：US15482696

申请日：2017-04-07

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/46 ,  A61F2/30 ,  A61M29/00

摘要： Surgical tools and kits are disclosed for repairing hyaline or meniscal cartilage, using membrane segments to protect and promote the growth and activity of cartilage-generating cells. These kits include: (i) a set of dilator tubes, adapted from similar tubes used in spinal surgery except shorter, that will allow a surgeon to progressively enlarge an insertion tunnel for inserting a membrane segment into an articulating joint that is being repaired; and, (ii) an assortment of membrane “tamping” devices, with smooth rounded “tamping heads” (or tips, etc.), and with a size and length that allow the tool tip to pass through the longest dilator tube while being held by the surgeon. Additional components (including disposable supplies) that can help facilitate these types of surgery can be included in any such kit, or in “supplemental” kits that can be bundled and shipped with these “primary” kits.

公开(公告)号：US20190322979A1

公开(公告)日：2019-10-24

申请号：US15600763

申请日：2017-05-21

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： C12M1/00 ,  A61K31/436 ,  A61K35/35 ,  A61L27/36 ,  A61M1/00 ,  C12N5/0775 ,  C12N5/077 ,  C12M1/26

摘要： Methods and devices are disclosed for processing stromal precursor cells (i.e., cells which can differentiate into connective tissue cells, such as in muscles, ligaments, or tendons) which can be obtained from fatty tissue extracts obtained via liposuction. Normal processing of a liposuction extract involves centrifugation, to concentrate the stromal cells into a semi-concentrated form called “spun fat”. That “spun fat” can then be treated by mechanical processing (such as pressure-driven extrusion through 0.5 mm holes) under conditions which can gently pry the stromal cells away from extra-cellular collagen fibers and other debris in the “spun fat”. The extruded mixture is then centrifuged again, to separate a highly-enriched population of stromal cells which is suited for injection back into the patient (along with platelet cells, if desired, to further promote tissue repair or regeneration).

公开(公告)号：US11771549B2

公开(公告)日：2023-10-03

申请号：US16587322

申请日：2019-09-30

申请人： Michael A. Scarpone

发明人： Michael A. Scarpone

IPC分类号： A61F2/08 ,  B33Y80/00

CPC分类号： A61F2/0811 ,  B33Y80/00 ,  A61F2002/0817 ,  A61F2002/0858

摘要： An implantable article for attaching tendons and/or ligaments to bone and/or cartilage, assemblies thereof, and methods of use thereof are provided. The article is configured for attaching at least one of a tendon and a ligament to at least one of bone and cartilage. The article comprises a membrane comprising a biological material that promotes cell growth. The membrane comprises a first end, a second end, a cavity, and an expandable portion. The second end is configured to be attached to at least one of the bone, the cartilage, the tendon, and the ligament. The cavity extends from the first end to the second end. The cavity is configured to receive the cell growth mixture from the open end. The expandable portion is positioned intermediate the first end and the second end and is configured to increase in size responsive to the cell growth mixture entering the cavity.