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公开(公告)号:US20050153978A1
公开(公告)日:2005-07-14
申请号:US10508592
申请日:2003-03-21
申请人: Michael Alberti , Stephen Garland , David Jung , James Veal , Jason Witherington
发明人: Michael Alberti , Stephen Garland , David Jung , James Veal , Jason Witherington
IPC分类号: A61K31/4184 , A61K31/4245 , A61K31/454 , A61K31/4725 , A61K31/496 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/06 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P43/00 , C07D403/04 , C07D413/04 , C07D413/14 , C07D471/06 , A61K31/4439 , A61K31/4709 , C07D43/14
CPC分类号: C07D403/04 , A61K31/4184 , C07D413/04 , C07D413/14 , C07D471/06
摘要: A method of treating an Msk-1 and/or ROCK(1 and 2) mediated disease or condition in a mammal comprising administration of an effective amount of a compounds of the formula (I) and physiologically acceptable salts thereof wherein, R1 is a 5, or 6 membered heterocyclic group selected from group a, b, c or d wherein X1 is a group selected from N or CR7 and X2 is a group selected from O, S or NR8; X3 and X4 which may be the same or different is a group selected from N or CR7; X5 is a group selected from O, S or NR8 and X6 is N or CR7; X7, X8 and X9 may be the same or different and selected from a group N or CR7, pharmaceutical compositions, novel compounds and processes for their preparation.
摘要翻译: 一种在哺乳动物中治疗Msk-1和/或ROCK(1和2)介导的疾病或病症的方法,包括施用有效量的式(I)化合物及其生理学上可接受的盐,其中R 1, 1是选自组a,b,c或d的5或6元杂环基团,其中X 1是选自N或CR 7的基团。 并且X 2是选自O,S或NR 8的基团。 X 3和X 4可以相同或不同,是选自N或CR 7的基团。 X 5是选自O,S或NR 8和X 6的基团是N或CR 7; X 7,X 8和X 9可以相同或不同,并且选自N或C 7 SUB >,药物组合物,新化合物及其制备方法。
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公开(公告)号:US20050090507A1
公开(公告)日:2005-04-28
申请号:US10499179
申请日:2002-12-11
申请人: Jennifer Badiang , Scott Dickerson , Philip Harris , David Jung , Michael Peel , Michael Reno , Tara Rheault , Kirk Stevens , Francis Tavares , James Veal
发明人: Jennifer Badiang , Scott Dickerson , Philip Harris , David Jung , Michael Peel , Michael Reno , Tara Rheault , Kirk Stevens , Francis Tavares , James Veal
IPC分类号: A61K31/506 , A61K31/5377 , A61K45/00 , A61P35/00 , A61P43/00 , C07D487/04 , A61K31/519
CPC分类号: C07D487/04
摘要: Fused pyradazine derivatives, which are useful as CDK inhibitors are described herein. The described invention also includes methods of making such fused pyradazines derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作CDK抑制剂的稠合的哒嗪衍生物。 所述的发明还包括制备这种稠合吡嗪嗪衍生物的方法以及使用其来治疗过度增殖性疾病的方法。
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公开(公告)号:US07678803B2
公开(公告)日:2010-03-16
申请号:US11844584
申请日:2007-08-24
申请人: Kenneth He Huang , James Veal , Thomas Barta , Emilie D. Smith , Wei Ma , Andy Ommen
发明人: Kenneth He Huang , James Veal , Thomas Barta , Emilie D. Smith , Wei Ma , Andy Ommen
IPC分类号: A61K31/517
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D471/04
摘要: The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Q1 is CR1, Q2 is N, Q4 and Q5 are each CR1, Q3 is CR2, X1 is N or CRc, Y is CRc, X2 and X3 are each C(R5)(R6), R7 is O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.
摘要翻译: 本发明涉及其中Q1是CR1,Q2是N,Q4和Q5各自是CR1,Q3是CR2,X1是N或CRc,Y是CRc,X2和X3各自为C的化合物和药学上可接受的盐 (R 5)(R 6),R 7为O.式I的化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症。本发明还涉及包含本发明化合物的药物组合物。
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公开(公告)号:US20080076800A1
公开(公告)日:2008-03-27
申请号:US11844629
申请日:2007-08-24
申请人: Kenneth Huang , Thomas Barta , Emilie Smith , Steven Hall , James Veal
发明人: Kenneth Huang , Thomas Barta , Emilie Smith , Steven Hall , James Veal
IPC分类号: A61K31/44 , A61K31/166 , A61K31/196 , A61K31/216 , A61K31/443 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/00 , C07D405/12 , C07D335/02 , C07D309/14 , C07D213/85 , C07D213/82 , C07D211/58 , C07C255/58 , C07C233/65 , C07C229/42 , A61P37/00 , A61P31/00 , A61P25/00 , A61K31/4465 , A61K31/277 , A61K31/351 , A61K31/382
CPC分类号: C07D213/84 , C07C255/58 , C07C255/59 , C07D211/58 , C07D213/81 , C07D213/82 , C07D213/85 , C07D309/14 , C07D335/02 , C07D405/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, R4, R5, RO, m, and p are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中A 1,Q 1,Q 2,Q 3,R 3, R 4,R 5,R 5,R O,m和p如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US20050085637A1
公开(公告)日:2005-04-21
申请号:US10503874
申请日:2003-02-07
申请人: Mui Cheung , Kristen Nailor , Douglas Sammond , James Veal
发明人: Mui Cheung , Kristen Nailor , Douglas Sammond , James Veal
IPC分类号: A61K31/505 , A61K31/506 , A61K45/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/02 , C07D239/48 , C07D251/48
CPC分类号: C07D239/48
摘要: Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US20110183977A1
公开(公告)日:2011-07-28
申请号:US13081637
申请日:2011-04-07
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/415 , A61K31/405 , C07D413/12 , C07D401/12 , C07D403/12 , C07D209/04 , A61P31/10 , C07D409/12 , C07D405/12 , A61P29/00 , A61P35/00 , A61P31/00 , A61P19/02 , A61P37/00 , A61P25/00 , A61P9/00 , A61P35/02 , A61P3/00 , A61P11/00
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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公开(公告)号:US20080070935A1
公开(公告)日:2008-03-20
申请号:US11844584
申请日:2007-08-24
申请人: Kenneth Huang , James Veal , Thomas Barta , Emilie Smith , Wei Ma , Andy Ommen
发明人: Kenneth Huang , James Veal , Thomas Barta , Emilie Smith , Wei Ma , Andy Ommen
IPC分类号: A61K31/517 , A61K31/47 , A61K31/519 , A61P25/00 , A61P3/00 , A61P31/10 , A61P37/00 , C07D217/22 , C07D401/10 , C07D403/02 , C07D401/14 , C07D239/72 , A61P9/00 , A61P35/00 , A61P31/00 , A61P29/00 , A61P19/02 , A61K31/4725
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D471/04
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R0, R5, R6, R7, n, Q1-Q5, Y, and X1-X3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R 0,R 5,R 6,R 7, ,n,Q 1 -Q 5,Y和X 1 -X 3 -X如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US20070010540A1
公开(公告)日:2007-01-11
申请号:US11430342
申请日:2006-05-09
申请人: Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
发明人: Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
IPC分类号: A61K31/505 , C07D403/02 , C07D239/48
CPC分类号: C12N9/12 , C07K14/7153 , C07K2299/00 , G06F19/16
摘要: A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.
摘要翻译: 具有结合的小分子的cfms激酶结构域,共晶体结构的晶体结构,以及在发现cfms抑制剂以及治疗不适当cfms活性介导的疾病的方法。
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公开(公告)号:US07928135B2
公开(公告)日:2011-04-19
申请号:US12907571
申请日:2010-10-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: C07D231/54 , A01N43/56
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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公开(公告)号:US20110034529A1
公开(公告)日:2011-02-10
申请号:US12907571
申请日:2010-10-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/416 , C07D231/56 , A61P35/00
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R1,R2,R3,R4,R5,R6,R7,n,Q1,Q2,Q3,Y和X1-X4如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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