公开(公告)号：US07405825B2

公开(公告)日：2008-07-29

申请号：US10539540

申请日：2003-12-19

申请人： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker ,  Wouter Harry Jacinth Rensen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Robert Frans Maria Hendriks ,  Thomas Steffen

发明人： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker ,  Wouter Harry Jacinth Rensen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Robert Frans Maria Hendriks ,  Thomas Steffen

IPC分类号： G01J3/32 ,  G01J3/457 ,  G02B26/02

CPC分类号： G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3196 ,  G01N2201/129

摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.

摘要翻译： 用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。 光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。 血液分析系统（40）包括根据本发明的光学分析系统（20）。

公开(公告)号：US07671973B2

公开(公告)日：2010-03-02

申请号：US10596564

申请日：2004-12-16

申请人： Michael Cornelis Van Beek ,  Frank Jeroen Pieter Schuurmans ,  Levinus Pieter Bakker

发明人： Michael Cornelis Van Beek ,  Frank Jeroen Pieter Schuurmans ,  Levinus Pieter Bakker

IPC分类号： G01N33/48

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  G01J3/36 ,  G01N21/65 ,  G01N33/49

摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.

摘要翻译： 本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。 主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。 光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。 光信号优选分为对应于加权函数的正和负光谱带的两部分。 分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。 光信号的分离和加权由两个多元光学元件实现。

公开(公告)号：US20090015819A1

公开(公告)日：2009-01-15

申请号：US10596563

申请日：2004-12-13

申请人： Michael Cornelis Van Beek ,  Bernardus Leonardus Bakker ,  Wouter Harry Jacinth Rensen ,  Frank Jeroen Pieter Schuurmans

发明人： Michael Cornelis Van Beek ,  Bernardus Leonardus Bakker ,  Wouter Harry Jacinth Rensen ,  Frank Jeroen Pieter Schuurmans

IPC分类号： G01N33/48

CPC分类号： G01N21/31 ,  G01J3/28 ,  G01N21/274 ,  G01N21/64 ,  G01N21/6445 ,  G01N21/65 ,  G01N2021/3196 ,  G01N2021/6417 ,  G01N2021/655

摘要： The optical analysis system (20) is arranged to determine an amplitude of a principal component of an optical signal. The optical analysis system (20) comprises a multivariate optical element (5, 6) for weighing the optical signal by a spectral weighing function and a detector (7, 8) for detecting the weighed optical signal. The optical signal comprises the principal component and a further component which was not accounted for when designing the spectral weighing function. Therefore, the detected weighed optical signal comprises a part relating to the amplitude of the principal component and a further part relating to a further amplitude of the further component. The optical analysis system (20) further comprises a modulator element (13) for modulating the detected weighed optical signal. The difference between the modulated detected weighed optical signal and the detected weighed optical signal relates to the amplitude of the principal component and thus allows for determining the amplitude of the principal component in an accurate way. The blood analysis system (40) comprises such an optical analysis system (20). The method of determining an amplitude of an principal component makes use of the optical analysis system (20).

摘要翻译： 光学分析系统（20）被布置成确定光信号的主分量的幅度。 光学分析系统（20）包括用于通过光谱称重功能称量光信号的多元光学元件（5,6）和用于检测加权光信号的检测器（7,8）。 光信号包括主分量和另外的分量，在设计光谱称重功能时不考虑。 因此，检测到的加权光信号包括与主分量的振幅有关的部分，以及与另一分量的另一幅度相关的另一部分。 光学分析系统（20）还包括用于调制检测到的称重光信号的调制器元件（13）。 调制检测到的称重光信号与检测到的称重光信号之间的差异与主分量的振幅有关，因此允许以准确的方式确定主分量的振幅。 血液分析系统（40）包括这样的光学分析系统（20）。 确定主成分的振幅的方法利用光学分析系统（20）。

公开(公告)号：US20080094623A1

公开(公告)日：2008-04-24

申请号：US11573799

申请日：2005-08-26

申请人： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort

发明人： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort

IPC分类号： G01J3/457 ,  G01J3/04 ,  G01R35/00

CPC分类号： G01J3/28 ,  G01J3/04 ,  G01J3/36 ,  G01J2003/047 ,  G01J2003/1278

摘要： The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.

摘要翻译： 本发明提供了基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。 光谱系统基于提供入射光信号的光谱加权的多元光学元件。 基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。 分光系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。 优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。

公开(公告)号：US20080309940A1

公开(公告)日：2008-12-18

申请号：US12094698

申请日：2006-11-20

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.

公开(公告)号：US20080309941A1

公开(公告)日：2008-12-18

申请号：US12094802

申请日：2006-11-20

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps:—coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.

公开(公告)号：US20080300472A1

公开(公告)日：2008-12-04

申请号：US12094670

申请日：2006-11-17

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： A61B5/1455

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  A61B5/1455 ,  A61B5/14551

摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.

摘要翻译： 公开了一种用于浑浊介质的光学成像的方法和装置。 该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。 此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤 对比强度。 对比图像与混浊介质的参考图像之间进行比较。

公开(公告)号：US20080290256A1

公开(公告)日：2008-11-27

申请号：US12094634

申请日：2006-11-21

申请人： Levinus Pieter Bakker ,  Gert T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

发明人： Levinus Pieter Bakker ,  Gert T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

IPC分类号： H03F3/08

CPC分类号： A61B5/4312 ,  A61B5/0091

摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.

摘要翻译： 本发明涉及一种用于对浑浊介质（55）的内部进行成像的方法和装置（1）。 从多个源位置（25a）利用来自光源（5）的光照射测量体积（15）内部的混浊介质（55），并且从测量体积（15）发出的光从多个 检测位置（25b）。 从检测到的光重建混浊介质（55）的内部的图像。 在方法和装置（1）中，通过包括放大器电路（60）的多增益放大单元，可以为每个源位置检测位置对放大检测器信号。 基于现有技术中检测到的信号强度，从多个可能的放大因子中选择放大因子。 然而，根据本发明，所述方法和装置被适配成使得根据预期的电信号强度的估计为至少一个源位置检测位置对选择放大系数。

公开(公告)号：US20080285823A1

公开(公告)日：2008-11-20

申请号：US12094641

申请日：2006-11-13

申请人： Levinus Pieter Bakker ,  Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark

发明人： Levinus Pieter Bakker ,  Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark

IPC分类号： G06K9/00

CPC分类号： G01N21/4795 ,  A61B5/0091 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/6421

摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.

摘要翻译： 本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。 装置（1）可以用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）内部的图像。 装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，用于检测至少两个光谱区域中的荧光发射 并且用于计算所检测的所述至少两个光谱区域的图像重建。 通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。

公开(公告)号：US07750331B2

公开(公告)日：2010-07-06

申请号：US12094634

申请日：2006-11-21

申请人： Levinus Pieter Bakker ,  Gert 'T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

发明人： Levinus Pieter Bakker ,  Gert 'T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

IPC分类号： G01N15/06 ,  G01N21/49 ,  G01N21/85

CPC分类号： A61B5/4312 ,  A61B5/0091

摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.

摘要翻译： 本发明涉及一种用于对浑浊介质（55）的内部进行成像的方法和装置（1）。 从多个源位置（25a）利用来自光源（5）的光照射测量体积（15）内部的混浊介质（55），并且从测量体积（15）发出的光从多个 检测位置（25b）。 从检测到的光重建混浊介质（55）的内部的图像。 在方法和装置（1）中，通过包括放大器电路（60）的多增益放大单元，可以为每个源位置检测位置对放大检测器信号。 基于现有技术中检测到的信号强度，从多个可能的放大因子中选择放大因子。 然而，根据本发明，所述方法和装置被适配成使得根据预期的电信号强度的估计为至少一个源位置检测位置对选择放大系数。