利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.027 秒)

    MULTIPLEXED ANALYSIS METHODS USING SERS-ACTIVE NANOPARTICLES
    1.
    发明申请
    MULTIPLEXED ANALYSIS METHODS USING SERS-ACTIVE NANOPARTICLES 审中-公开
    使用活性纳米粒子的多重分析方法

    公开(公告)号：US20100279272A1

    公开(公告)日：2010-11-04

    申请号：US12030609

    申请日：2008-02-13

    申请人： Michael Craig Burrell ,  John Yupeng Gui ,  Frank John Mondello ,  Andrew David Pris ,  Tracy Lynn Paxon

    发明人： Michael Craig Burrell ,  John Yupeng Gui ,  Frank John Mondello ,  Andrew David Pris ,  Tracy Lynn Paxon

    IPC分类号： C12Q1/70 ,  G01N33/53 ,  G01N33/00

    CPC分类号： G01N33/54373 ,  G01N21/658 ,  Y10T436/143333

    摘要： Methods are described for performing a multiplexed analysis of a level of target analyte in a sample, employing an identifier and a labeling reagent. Either or both of the identifier and the labeling reagent comprises a SERS-active nanoparticle associated with a SERS-active reporter with a uniquely identifiable spectroscopic signature. Interrogation of the identifier and the labeling reagent is conducted by serial coincident detection. Such methods can provide enhanced multiplexed analysis of analytes in a sample, especially with regards to improving the type of identifying reagents that are employed.

    摘要翻译： 描述了使用标识符和标记试剂进行样品中目标分析物水平的多重分析的方法。 标识符和标记试剂中的任一个或两者包含与具有唯一可识别的光谱特征的SERS-活性报道分子相关联的SERS活性纳米颗粒。 标识符和标记试剂的询问通过串行重合检测进行。 这样的方法可以提供样品中分析物的增强的多重分析，特别是关于改进所采用的鉴定试剂的类型。

    System and method for increasing spectroscopic signal
    2.
    发明授权
    System and method for increasing spectroscopic signal 有权
    增加光谱信号的系统和方法

    公开(公告)号：US08440469B2

    公开(公告)日：2013-05-14

    申请号：US11764537

    申请日：2007-06-18

    申请人： Tracy Lynn Paxon ,  Frank John Mondello ,  Yuan-Hsiang Lee ,  Michael Craig Burrell

    发明人： Tracy Lynn Paxon ,  Frank John Mondello ,  Yuan-Hsiang Lee ,  Michael Craig Burrell

    IPC分类号： G01N33/553 ,  G01N33/543

    CPC分类号： G01N21/6428 ,  G01N33/54333

    摘要： A method for increasing a spectroscopic signal in a biological assay is provided. The method includes forming a suspension of magnetically attractable particles. The method also includes introducing a first magnetic field at a first location to draw the magnetically attractable particles towards the first location and form a first agglomeration. The method also includes removing the first magnetic field. The method further includes introducing a second magnetic field at a second location to draw the first agglomeration towards the second location and form a second agglomeration. The method further includes focusing an excitation source on the second agglomeration formed at the second location.

    摘要翻译： 提供了用于增加生物测定中的光谱信号的方法。 该方法包括形成磁吸引颗粒的悬浮液。 该方法还包括在第一位置引入第一磁场以将磁性可吸引颗粒吸引到第一位置并形成第一附聚。 该方法还包括去除第一磁场。 该方法还包括在第二位置引入第二磁场以将第一附聚物吸引到第二位置并形成第二聚集。 该方法还包括将激发源聚焦在形成在第二位置处的第二聚集体上。

    SYSTEM AND METHOD FOR INCREASING SPECTROSCOPIC SIGNAL
    3.
    发明申请
    SYSTEM AND METHOD FOR INCREASING SPECTROSCOPIC SIGNAL 有权
    增加光谱信号的系统和方法

    公开(公告)号：US20080309335A1

    公开(公告)日：2008-12-18

    申请号：US11764537

    申请日：2007-06-18

    申请人： Tracy Lynn Paxon ,  Frank John Mondello ,  Yuan-Hsiang Lee ,  Michael Craig Burrell

    发明人： Tracy Lynn Paxon ,  Frank John Mondello ,  Yuan-Hsiang Lee ,  Michael Craig Burrell

    IPC分类号： G01R33/465

    CPC分类号： G01N21/6428 ,  G01N33/54333

    摘要： A method for increasing a spectroscopic signal in a biological assay is provided. The method includes forming a suspension of magnetically attractable particles. The method also includes introducing a first magnetic field at a first location to draw the magnetically attractable particles towards the first location and form a first agglomeration. The method also includes removing the first magnetic field. The method further includes introducing a second magnetic field at a second location to draw the first agglomeration towards the second location and form a second agglomeration. The method further includes focusing an excitation source on the second agglomeration formed at the second location.

    摘要翻译： 提供了用于增加生物测定中的光谱信号的方法。 该方法包括形成磁吸引颗粒的悬浮液。 该方法还包括在第一位置引入第一磁场以将磁性可吸引颗粒吸引到第一位置并形成第一附聚。 该方法还包括去除第一磁场。 该方法还包括在第二位置引入第二磁场以将第一附聚物吸引到第二位置并形成第二聚集。 该方法还包括将激发源聚焦在形成在第二位置处的第二聚集体上。

    AGENTS AND METHODS FOR SPECTROMETRIC ANALYSIS
    5.
    发明申请
    AGENTS AND METHODS FOR SPECTROMETRIC ANALYSIS 审中-公开
    用于光谱分析的试剂和方法

    公开(公告)号：US20100129795A1

    公开(公告)日：2010-05-27

    申请号：US12275753

    申请日：2008-11-21

    申请人： Andrew David Pris ,  Tracy Lynn Paxon ,  Anthony John Murray

    发明人： Andrew David Pris ,  Tracy Lynn Paxon ,  Anthony John Murray

    IPC分类号： C12Q1/68 ,  G01N33/566

    CPC分类号： G01N33/54306

    摘要： Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.

    摘要翻译： 本文公开了用于以单一或多路复用的方式确定样品中靶或多个靶的存在或浓度的试剂，方法和试剂盒。 通常，这些方法可以分析在液相中产生或消耗的小分子，这些分子可以使用气相或气相检测方法进行分析。

    Methods for amplifying the Raman signal of surface enhanced Raman scattering nanoparticles
    6.
    发明申请
    Methods for amplifying the Raman signal of surface enhanced Raman scattering nanoparticles 有权
    放大表面增强拉曼散射纳米粒子拉曼信号的方法

    公开(公告)号：US20080118986A1

    公开(公告)日：2008-05-22

    申请号：US11602755

    申请日：2006-11-21

    申请人： Michael Burrell ,  Frank John Mondello ,  Tracy Lynn Paxon

    发明人： Michael Burrell ,  Frank John Mondello ,  Tracy Lynn Paxon

    IPC分类号： G01N21/31

    CPC分类号： G01N33/587 ,  B82Y15/00 ,  G01N21/658

    摘要： Methods for amplifying the Raman signal of primary SERS nanoparticles are provided. One method generally includes binding secondary SERS particles to the primary SERS nanoparticles after binding of the primary SERS nanoparticles. In another method, secondary SERS nanoparticles are brought in close proximity to the primary SERS nanoparticles, wherein the secondary nanoparticles are free of a reporter molecule or have a reporter molecule different from that of the primary SERS nanoparticles.

    摘要翻译： 提供了扩增主SERS纳米粒子的拉曼信号的方法。 一种方法通常包括在初级SERS纳米颗粒结合后将次级SERS颗粒结合到主SERS纳米颗粒。 在另一种方法中，次级SERS纳米颗粒紧密接近主SERS纳米颗粒，其中二级纳米颗粒不含报告分子或具有不同于主要SERS纳米颗粒的报告分子。

    SYSTEM AND METHOD FOR IMPROVED BIODETECTION
    7.
    发明申请
    SYSTEM AND METHOD FOR IMPROVED BIODETECTION 有权
    改进生物防治的系统和方法

    公开(公告)号：US20090168052A1

    公开(公告)日：2009-07-02

    申请号：US11966332

    申请日：2007-12-28

    申请人： Michael Craig Burrell ,  Frank Mondello ,  Tracy Lynn Paxon ,  William Scott Sutherland ,  Christopher Montalbano ,  Gregory Montalbano ,  Aaron Klein

    发明人： Michael Craig Burrell ,  Frank Mondello ,  Tracy Lynn Paxon ,  William Scott Sutherland ,  Christopher Montalbano ,  Gregory Montalbano ,  Aaron Klein

    IPC分类号： G01N1/00

    CPC分类号： G01N21/65 ,  G01N1/405 ,  G01N21/658

    摘要： A portable substance identification system and method are configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. An embodiment of the portable substance identification system includes a portable substance identification device containing a Raman spectrometer, and a collection stem that includes a dry collector. One or more reservoirs for a liquid medium and /or a reagent can be formed in a cartridge that is configured to couple with a portable substance identification device. The cartridge has a chamber in which the reagent, liquid medium, and a detection target picked up by the dry collector are mixed. A magnet, positioned at a slant angle, can be used to form at least one pellet of aggregated magnetic particles within a pellet forming area of the chamber. The pellet is formed to maximize its surface area.

    摘要翻译： 便携式物质识别系统和方法被配置为比使用先前物质识别系统和/或先前物质识别技术更快，更准确地识别至少一个检测目标。 便携式物质识别系统的实施例包括含有拉曼光谱仪的便携式物质识别装置和包括干燥收集器的收集杆。 用于液体介质和/或试剂的一个或多个储存器可以形成在配置成与便携式物质识别装置联接的盒中。 该盒具有混合由干燥收集器拾取的试剂，液体介质和检测对象的室。 以倾斜角定位的磁体可以用于在腔室的颗粒形成区域内形成至少一个聚集的磁性颗粒颗粒。 形成颗粒使其表面积最大化。

    SYSTEM FOR IMPROVED BIODETECTION
    8.
    发明申请
    SYSTEM FOR IMPROVED BIODETECTION 审中-公开
    改进生物保护系统

    公开(公告)号：US20090169433A1

    公开(公告)日：2009-07-02

    申请号：US11966378

    申请日：2007-12-28

    申请人： Sankaran Kumar ,  Christopher Crowley ,  Erik Edmund Magnuson ,  Michael Craig Burrell ,  Frank Mondello ,  Tracy Lynn Paxon

    发明人： Sankaran Kumar ,  Christopher Crowley ,  Erik Edmund Magnuson ,  Michael Craig Burrell ,  Frank Mondello ,  Tracy Lynn Paxon

    IPC分类号： G01N21/31

    CPC分类号： G01N21/658 ,  G01N2021/651

    摘要： A substance identification system is configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. A chamber includes a pellet forming area having a predetermined geometry that is configured to maximize a ratio of a pellet surface area to a pellet volume. A magnet is positioned on one side of the chamber and configured to form a pellet of aggregated magnetic particles in the pellet forming area. A laser source is positioned on the same side of the chamber as the magnet and configured to illuminate the pellet, when the pellet is formed in the pellet forming area.

    摘要翻译： 物质识别系统配置成比使用先前物质识别系统和/或先前物质识别技术更快，更准确地识别至少一个检测目标。 腔室包括具有预定几何形状的丸粒形成区域，其被构造成使球团表面积与球团体积的比例最大化。 磁体位于室的一侧，并且构造成在颗粒形成区域中形成聚集的磁性颗粒的颗粒。 当颗粒形成在颗粒形成区域中时，激光源被定位在与磁体相同的腔室的相同侧上并被配置为照射颗粒。

    System and method for improved biodetection
    9.
    发明授权
    System and method for improved biodetection 有权
    改进生物检测的系统和方法

    公开(公告)号：US07847932B2

    公开(公告)日：2010-12-07

    申请号：US11966279

    申请日：2007-12-28

    申请人： Michael Craig Burrell ,  Frank Mondello ,  Tracy Lynn Paxon ,  William Scott Sutherland ,  Christopher Montalbano ,  Gregory Montalbano ,  Aaron Klein

    发明人： Michael Craig Burrell ,  Frank Mondello ,  Tracy Lynn Paxon ,  William Scott Sutherland ,  Christopher Montalbano ,  Gregory Montalbano ,  Aaron Klein

    IPC分类号： G01J3/44

    CPC分类号： G01N21/658 ,  G01N2021/651 ,  G01N2201/0221

    摘要： Portable substance identification system and method are configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. An embodiment of the portable substance identification system includes a portable substance identification device containing a Raman spectrometer, and a collection stem that includes a collector. One or more reservoirs for a liquid medium and/or at least one reagent can be formed in the collection stem. The cartridge can include a chamber in which the reagents, liquid medium, and at least one detection target picked up by the collector are mixed. A magnet, positioned at a slant angle, can be used to form at least one pellet of aggregated magnetic particles within a pellet forming area of the chamber. The pellet is formed to maximize its surface area.

    摘要翻译： 便携式物质识别系统和方法配置成比使用先前物质识别系统和/或先前物质识别技术更快，更准确地识别至少一个检测目标。 便携式物质识别系统的实施例包括包含拉曼光谱仪的便携式物质识别装置和包括收集器的收集杆。 用于液体介质和/或至少一种试剂的一个或多个储存器可以形成在收集杆中。 药筒可以包括其中混合有由试剂，液体介质和由收集器拾取的至少一个检测目标的室。 以倾斜角定位的磁体可以用于在腔室的颗粒形成区域内形成至少一个聚集的磁性颗粒颗粒。 形成颗粒使其表面积最大化。