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1.发明申请公开(公告)号：US20110112137A1
公开(公告)日：2011-05-12
申请号：US12919011
申请日：2009-02-23
申请人： Michael Eissenstat , Dehui Duan , John W. Erickson
发明人： Michael Eissenstat , Dehui Duan , John W. Erickson
IPC分类号： A61K31/4355 , A61K31/343 , A61P31/12 , A61P31/14 , A61P31/18 , A61K31/443 , A61K31/4178 , A61K31/4155 , A61K31/444 , A61K31/427 , A61K31/4709 , A61K31/437 , A61K31/4196
CPC分类号： A61K45/06 , A61K31/34 , A61K2300/00
摘要： Compositions and methods of treating viral infections are provided. More particularly, compositions including a combination of protease inhibitors and cytochrome p450 enzyme inhibitors are provided. Methods of using the compositions for treatment of diseases or disorders caused by a virus such as HIV infections are also provided.
摘要翻译： 提供了治疗病毒感染的组合物和方法。 更具体地，提供包含蛋白酶抑制剂和细胞色素p450酶抑制剂的组合的组合物。 还提供了使用组合物治疗由病毒如HIV感染引起的疾病或病症的方法。
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公开(公告)号：US08952056B2
公开(公告)日：2015-02-10
申请号：US12919012
申请日：2009-02-23
申请人： Michael Eissenstat , Dehui Duan , Sergi Gulnik , John W. Erickson
发明人： Michael Eissenstat , Dehui Duan , Sergi Gulnik , John W. Erickson
IPC分类号： A61K31/343 , C07D307/78 , C07D307/79
CPC分类号： C07D307/79 , A61K31/343 , A61K45/06
摘要： Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
摘要翻译： 提供抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。
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3.发明授权公开(公告)号：US08673970B2
公开(公告)日：2014-03-18
申请号：US12919011
申请日：2009-02-23
申请人： Michael Eissenstat , Dehui Duan , John W. Erickson
发明人： Michael Eissenstat , Dehui Duan , John W. Erickson
CPC分类号： A61K45/06 , A61K31/34 , A61K2300/00
摘要： Compositions and methods of treating viral infections are provided. More particularly, compositions including a combination of protease inhibitors and cytochrome p450 enzyme inhibitors are provided. Methods of using the compositions for treatment of diseases or disorders caused by a virus such as HIV infections are also provided.
摘要翻译： 提供了治疗病毒感染的组合物和方法。 更具体地，提供包含蛋白酶抑制剂和细胞色素p450酶抑制剂的组合的组合物。 还提供了使用组合物治疗由病毒如HIV感染引起的疾病或病症的方法。
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公开(公告)号：US20110098237A1
公开(公告)日：2011-04-28
申请号：US12919012
申请日：2009-02-23
申请人： Michael Eissenstat , Dehui Duan , Sergi Gulnik , John W. Erickson
发明人： Michael Eissenstat , Dehui Duan , Sergi Gulnik , John W. Erickson
IPC分类号： A61K31/343 , C07D307/79 , C07D405/14 , C07D405/12 , C07D493/04 , C07D417/12 , C07D417/14 , C07D471/02 , C07D491/048 , C07D407/12 , A61K31/443 , A61K31/4178 , A61K31/4155 , A61K31/444 , A61K31/34 , A61K31/427 , A61K31/4709 , A61K31/437 , A61K31/4196 , A61K31/4355 , A61K38/13 , A61K31/436 , A61K31/496 , A61K31/4725 , A61K31/4439 , A61K31/7048 , A61K31/44 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/5513 , A61K31/565 , A61P29/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P35/00 , A61P25/28 , A61P3/10 , A61P9/00 , A61P31/00 , A61P31/18 , A61P31/14
CPC分类号： C07D307/79 , A61K31/343 , A61K45/06
摘要： Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
摘要翻译： 提供抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。
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![Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor](/abs-image/US/2007/01/02/US07157495B2/abs.jpg.150x150.jpg)
5.发明授权Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor 有权六氢呋喃并[2,3-B]呋喃-3-基）-N- {3 - [（1,3-苯并间二氧杂环戊烯-5-基磺酰基）（异丁基）氨基] -1-苄基-2-羟丙基}氨基甲酸酯作为逆转录病毒蛋白酶抑制剂公开(公告)号：US07157495B2
公开(公告)日：2007-01-02
申请号：US10606342
申请日：2003-06-25
IPC分类号： A61K31/35
CPC分类号： C07D493/04
摘要： Compositions comprising bis-tetrahydrofuran benzodioxyolyl sulfonamide compounds that are surprisingly effective protease inhibitors and a second antiretroviral compound are disclosed. Methods of inhibiting retrovirus proteases, in particular multi-drug resistant retrovirus proteases, methods of treating or preventing infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication are also disclosed.
摘要翻译： 公开了包含令人惊讶的有效蛋白酶抑制剂和第二抗逆转录病毒化合物的双 - 四氢呋喃苯并二氧基甲硅烷基磺酰胺化合物的组合物。 还公开了抑制逆转录病毒蛋白酶，特别是多药耐药逆转录病毒蛋白酶的方法，治疗或预防哺乳动物中与逆转录病毒感染相关的感染或疾病的方法，以及抑制病毒复制的方法。
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公开(公告)号：US07109230B2
公开(公告)日：2006-09-19
申请号：US10337349
申请日：2003-01-07
IPC分类号： A61K31/40 , C07D209/36
CPC分类号： G06F19/706 , A61K31/337 , C07D275/03 , C07D307/20 , C07D491/04 , C07D493/04 , C07D495/04 , C07K2299/00 , C12N9/506 , C12N9/88 , G06F19/16 , G06F19/18 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A90/26
摘要： Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.
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公开(公告)号：US20100009935A1
公开(公告)日：2010-01-14
申请号：US12504277
申请日：2009-07-16
IPC分类号： A61K31/675 , C07D493/04 , C07D293/10 , C07D307/87 , C07D277/62 , C07D209/04 , C07D311/04 , A61K31/34 , A61K31/36 , A61K31/352 , A61K31/403 , A61K31/428 , A61P31/12
CPC分类号： C12N9/88 , A61K31/337 , C07D275/03 , C07D307/20 , C07D491/04 , C07D493/04 , C07D495/04 , C07K2299/00 , C12N9/506 , G16B15/00 , G16B20/00 , G16C20/50 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A90/26
摘要： Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.
摘要翻译： 提供抗驱虫和多药耐药的逆转录病毒蛋白酶抑制剂。 还提供了包含这些化合物的药物组合物，以及使用这些化合物治疗哺乳动物HIV感染的方法。
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公开(公告)号：US07285566B2
公开(公告)日：2007-10-23
申请号：US10500888
申请日：2003-01-07
IPC分类号： A61K31/404 , C07D209/30
CPC分类号： C12N9/88 , C07K2299/00 , G06F19/16
摘要： Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.
摘要翻译： 提供抗驱虫和多药耐药的逆转录病毒蛋白酶抑制剂。 还提供了包含这些化合物的药物组合物，以及使用这些化合物治疗哺乳动物HIV感染的方法。
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![Hexahydrofuro[2,3-B]furan-3-yl-n{3[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor](/abs-image/US/2003/11/18/US06649651B1/abs.jpg.150x150.jpg)
9.发明授权Hexahydrofuro[2,3-B]furan-3-yl-n{3[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor 有权六氢呋喃并[2,3-B]呋喃-3-基] - {3 [（1,3-苯并间二氧杂环戊烯-5-基磺酰基）（异丁基）氨基] -1-苄基-2-羟丙基}氨基甲酸酯作为逆转录病毒蛋白酶抑制剂公开(公告)号：US06649651B1
公开(公告)日：2003-11-18
申请号：US10089991
申请日：2002-12-23
IPC分类号： A61K3136
CPC分类号： C07D493/04
摘要： Novel bis-tetrahydrofuran benzodioxolyl sulfonamide compounds which are surprisingly effective protease inhibitors. The invention also relates to pharmaceutical compositions, methods of inhibiting retrovirus proteases, in particular multidrug resistant retrovirus proteases, methods of treating or combating infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication.
摘要翻译： 新颖的双 - 四氢呋喃苯并二氧杂环戊烯基磺酰胺化合物是惊人的有效的蛋白酶抑制剂。 本发明还涉及药物组合物，抑制逆转录病毒蛋白酶，特别是多重耐药性逆转录病毒蛋白酶的方法，治疗或抗击哺乳动物中与逆转录病毒感染相关的感染或疾病的方法，以及抑制病毒复制的方法。
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公开(公告)号：US20110166061A1
公开(公告)日：2011-07-07
申请号：US12767646
申请日：2010-04-26
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物 的治疗各自病毒感染的作用。
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